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FB2026_01
,
released March 12, 2026
l(3)09645, ECT2
a Rho GEF required for the formation of the contractile ring and the initiation of cytokinesis - acts via Rho and polarity proteins to direct the assembly of an isotropic actomyosin cortex upon mitotic entry
Please see the JBrowse view of Dmel\pbl for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.50
5.5, 4.0 (northern blot)
None of the polypeptides share 100% sequence identity.
853 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pbl using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
pbl protein is expressed dynamically during the cell cycle. It is not detected during late prophase, metaphase, or early anaphase. It is first detected in late anaphase where it colocalizes with the separate chromosomes, reaches a peak in telophase nuclei, and persists into interphase. pbl protein is also associated with the cleavage furrow during cytokinesis.
Comment: low expression in the adult brain cortex
JBrowse - Visual display of RNA-Seq signals
View Dmel\pbl in JBrowse3-21
3-18.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Sema-1a-mediated motor axon defasciculation is promoted by pbl and inhibited by RhoGAPp190. The opposing pbl and RhoGAPp190 functions mediate Sema-1a reverse signaling through the regulation of Rho1 activity.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells, cells become round and detached.
Candidate gene for quantitative trait (QTL) locus determining bristle number.
pbl is required for the formation of the contractile ring and the initiation of cytokinesis.
Zygotic expression of pbl is required for cytokinesis following cellularization during embryogenesis: mutations in pbl result in disruption of cell proliferation.
pbl+ is required for coordination of the mitotic spindle and contractile ring functions. Maternal pbl product is probably required for early pole cell divisions.
pbl mutants display rudimentary head skeleton, denticle bands and filzkorper and the posterior end of the embryo remains on the dorsal side.
Source for merge of: pbl l(3)09645
Source for merge of: pbl anon-WO0172774.22 anon-WO0172774.25
Source for merge of pbl anon-WO0172774.22 anon-WO0172774.25 was sequence comparison ( date:051113 ).
