FB2026_02 , released June 18, 2026
Gene Group: RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
Open Close
General Information
Name
RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
Species
D. melanogaster
Symbol
RHOGEF
FlyBase ID
FBgg0000336
Date last reviewed
2024-07-01
Number of members
27
Description
Description
RhoGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Rho family GTPases. They include Dbl-homology domain-containing proteins (the largest family of RhoGEFs) and CZH2 domain/Dock family GEFs. (Adapted from FBrf0190957).
Notes on Group

RhoGAP1A has both RhoGAP and RhoGEF domains. It is likely that these domains target different Rho subfamilies (FBrf0158741).

Source Material
The RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS Gene Group has been compiled using the following publication(s): Sampson et al., 2012, Greenberg and Hatini, 2011, Higuchi et al., 2009, van Impel et al., 2009, Meller et al., 2005, and Bernards, 2003 .
Key Gene Ontology (GO) terms
Molecular Function
guanyl-nucleotide exchange factor activity
Biological Process
regulation of Rho protein signal transduction
Cellular Component
Related Gene Groups
Parent group(s)
RAS SUPERFAMILY GUANINE NUCLEOTIDE EXCHANGE FACTORS
Other related group(s)
RHO GTPASE ACTIVATING PROTEINS
RHO GTPASES
Members (27)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
RHOGEF
Ras Homologous guanine nucleotide exchange factors
Dbl-homology domain-containing GEFs
CZH2 domain GEFs
Dock family GEFs
Rho-GEF
DH GEF
RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
RHO NUCLEOTIDE EXCHANGE FACTORS
Secondary FlyBase ID(s)
References (7)