FB2026_02 , released June 18, 2026
Allele: Dmel\pbl1
Open Close
General Information
Symbol
Dmel\pbl1
Species
D. melanogaster
Name
FlyBase ID
FBal0013545
Feature type
allele
Associated gene
Dmel\pbl
Associated Insertion(s)
Carried in Construct
Also Known As
pbl5B
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nuclei reduced in number and exhibit gross morphological alterations. Cells are multinucleate and may have more than one spindle after postblastoderm mitoses.

      (Hime and Saint, 1992)

      Cytokinesis fails although cellularization and nuclear aspects of mitosis are normal.

      (Lehner, 1992)

      cold-sensitive embryonic lethal Mutant embryos have rudimentary head skeleton, denticle bands and filzkorper; posterior end is on dorsal side. Mitosis defective resulting in fewer and much larger cells in embryo.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      pbl1 is a suppressor of visible phenotype of Rho1GMR.PH

      (Prokopenko et al., 1999)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      pbl1 is a suppressor of eye phenotype of Rho1GMR.PH

      (Prokopenko et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Acts as a dominant suppressor of the Rho1GMR.PH-induced rough eye phenotype.

      (Prokopenko et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pbl1
      pbl5B
      (Grosskortenhaus et al., 2005, Hime and Saint, 1992, Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)