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General Information
Symbol
Dmel\Rho1GMR.PH
Species
D. melanogaster
Name
glass multimer reporter construct of Hariharan
FlyBase ID
FBal0042728
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-RhoA, GMR-Rho1, GMR-Rho1Rho3
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

GMR regulatory sequences drive expression of a 779bp EcoRI fragment of Rho1 cDNA that contains the entire coding region.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing Rho1GMR.PH have a rough eye phenotype associated with the frequent fusion of ommatidial units and misoriented or missing bristles.

Rho1GMR.PH flies display a rough eye phenotype.

Rho1GMR.PH flies have a rough eye phenotype.

Flies expressing Rho1GMR.PH have a rough eye phenotype with a dramatic disruption of the ommatidial architecture. The retina is reduced in thickness and the lattices that are normally formed by the secondary and tertiary pigment cells are completely missing. Pigment cells are restricted to apical regions of the retina.

Flies carrying two copies of the P{GMR-Rho1} insertion responsible for this allele, have an intermediate rough eye phenotype.

Rough patterned eye with misshapen, fused and flattened ommatidia.

Expression of Rho1GMR.PH in a wild-type background does not disrupt photoreceptor axon projections.

Causes a rough eye phenotype.

Pigment cells fail to extend to the retinal floor and the layer of pigment cell feet seen at the floor of the retina in wild-type animals is not seen in flies carrying one copy of Rho1GMR.PH.

Flies carrying Rho1GMR.PH have rough eyes, with both the external and internal ordered structure of the eye being disrupted. The thickness of the retina is reduced.

One copy of P{GMR-Rho1} allows normal external morphology, internal structure shows rhabdomeres are arranged in an irregular manner, but the eyes deform easily on application of mild pressure compared to wild type. Two copies, obtained by making the insertions homozygous, cause extremely rough eyes and flies carrying two copies, generated by crossing lines, have moderately rough eyes with a glassy appearance. Rough eye phenotype is due to a dramatic disruption of ommatidial architecture caused by disruption of cell differentiation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference

Rho1GMR.PH has visible phenotype, non-enhanceable by CE3-2unspecified

Rho1GMR.PH has visible phenotype, non-enhanceable by CE3-3unspecified

Rho1GMR.PH has visible phenotype, non-enhanceable by CS3-1unspecified

Rho1GMR.PH has visible phenotype, non-enhanceable by CS3-2unspecified

Rho1GMR.PH has visible phenotype, non-enhanceable by CS3-4unspecified

Rho1GMR.PH has visible phenotype, non-enhanceable by CanB2unspecified

Rho1GMR.PH has visible phenotype, non-enhanceable by styunspecified

Rho1GMR.PH has visible phenotype, non-enhanceable by CE2-2unspecified

Rho1GMR.PH has visible phenotype, non-enhanceable by CE2-3unspecified

Suppressed by
Statement
Reference

Rho1GMR.PH has visible phenotype, suppressible | partially by ParpGMR.PU

Rho1GMR.PH has visible phenotype, suppressible by dia2

Rho1GMR.PH has visible phenotype, suppressible by pbl1

Rho1GMR.PH has visible phenotype, suppressible by pbl2

Rho1GMR.PH has visible phenotype, suppressible by pbl3

Rho1GMR.PH has visible phenotype, suppressible by pbl5

Rho1GMR.PH has visible phenotype, suppressible by pblP81

Rho1GMR.PH has visible phenotype, suppressible by pblS23

Rho1GMR.PH has visible phenotype, suppressible by pblV58

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF204291

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF21.1

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF22.3

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF22.6

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF22.9

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF24.1

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF24.4

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF25.1

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF25.2

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF26.5

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF28.1

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF28.9

Rho1GMR.PH has visible phenotype, suppressible by RhoGEF29.6

NOT suppressed by
Statement
Reference

Rho1GMR.PH has visible phenotype, non-suppressible by CE2-2unspecified

Rho1GMR.PH has visible phenotype, non-suppressible by CS3-2unspecified

Rho1GMR.PH has visible phenotype, non-suppressible by CS3-4unspecified

Rho1GMR.PH has visible phenotype, non-suppressible by CanB2unspecified

Rho1GMR.PH has visible phenotype, non-suppressible by styunspecified

Rho1GMR.PH has visible phenotype, non-suppressible by CE2-3unspecified

Rho1GMR.PH has visible phenotype, non-suppressible by CE3-2unspecified

Rho1GMR.PH has visible phenotype, non-suppressible by CE3-3unspecified

Rho1GMR.PH has visible phenotype, non-suppressible by CS3-1unspecified

Rho1GMR.PH has visible phenotype, non-suppressible by Sps1k11320

Rho1GMR.PH has visible phenotype, non-suppressible by trio[+]/trio2H

Enhancer of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

Rho1GMR.PH has interommatidial bristle phenotype, enhanceable by Mbs[+]/Mbs03802

Rho1GMR.PH has eye phenotype, enhanceable by Mbs[+]/Mbs03802

NOT Enhanced by
Statement
Reference

Rho1GMR.PH has eye phenotype, non-enhanceable by CE3-2unspecified

Rho1GMR.PH has eye phenotype, non-enhanceable by CE3-3unspecified

Rho1GMR.PH has eye phenotype, non-enhanceable by CS3-1unspecified

Rho1GMR.PH has eye phenotype, non-enhanceable by CS3-2unspecified

Rho1GMR.PH has eye phenotype, non-enhanceable by CS3-4unspecified

Rho1GMR.PH has eye phenotype, non-enhanceable by CanB2unspecified

Rho1GMR.PH has eye phenotype, non-enhanceable by styunspecified

Rho1GMR.PH has eye phenotype, non-enhanceable by CE2-2unspecified

Rho1GMR.PH has eye phenotype, non-enhanceable by CE2-3unspecified

Rho1GMR.PH has phenotype, non-enhanceable by osaE65

Suppressed by
Statement
Reference

Rho1GMR.PH has eye phenotype, suppressible by PaxGMR.PC

Rho1GMR.PH has phenotype, suppressible by lilliXS407/lilliXS407

Rho1GMR.PH has phenotype, suppressible by lillis35

Rho1GMR.PH has phenotype, suppressible by lilliXS575

Rho1GMR.PH has eye phenotype, suppressible by dia2

Rho1GMR.PH has eye phenotype, suppressible by pbl1

Rho1GMR.PH has eye phenotype, suppressible by pbl2

Rho1GMR.PH has eye phenotype, suppressible by pbl3

Rho1GMR.PH has eye phenotype, suppressible by pbl5

Rho1GMR.PH has eye phenotype, suppressible by pblP81

Rho1GMR.PH has eye phenotype, suppressible by pblS23

Rho1GMR.PH has eye phenotype, suppressible by pblV58

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF204291

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF21.1

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF22.3

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF22.6

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF22.9

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF24.1

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF24.4

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF25.1

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF25.2

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF26.5

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF28.1

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF28.9

Rho1GMR.PH has eye phenotype, suppressible by RhoGEF29.6

Rho1GMR.PH has eye phenotype, suppressible by Cdc37e1E

NOT suppressed by
Statement
Reference

Rho1GMR.PH has eye phenotype, non-suppressible by CS3-1unspecified

Rho1GMR.PH has eye phenotype, non-suppressible by CS3-2unspecified

Rho1GMR.PH has eye phenotype, non-suppressible by CS3-4unspecified

Rho1GMR.PH has eye phenotype, non-suppressible by CanB2unspecified

Rho1GMR.PH has eye phenotype, non-suppressible by styunspecified

Rho1GMR.PH has eye phenotype, non-suppressible by CE2-2unspecified

Rho1GMR.PH has eye phenotype, non-suppressible by CE2-3unspecified

Rho1GMR.PH has eye phenotype, non-suppressible by CE3-2unspecified

Rho1GMR.PH has eye phenotype, non-suppressible by CE3-3unspecified

Rho1GMR.PH has eye phenotype, non-suppressible by trio[+]/trio2H

Rho1GMR.PH has ommatidium phenotype, non-suppressible by trio[+]/trio2H

Rho1GMR.PH has eye phenotype, non-suppressible by mbc1.63

Rho1GMR.PH has eye phenotype, non-suppressible by mbc2.35

Rho1GMR.PH has eye phenotype, non-suppressible by mbc3.5

Rho1GMR.PH has eye phenotype, non-suppressible by mbc4.25

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

Rho1GMR.PH is a non-enhancer of phenotype of trioGEF1.GMR.Tag:MYC

NOT Suppressor of
Statement
Reference

Rho1GMR.PH is a non-suppressor of phenotype of trioGEF1.GMR.Tag:MYC

Additional Comments
Genetic Interactions
Statement
Reference

The rough-eye phenotype of Rho1GMR.PH flies is much reduced when PaxGMR.PC is co-expressed.

The rough eye phenotype of Rho1GMR.PH flies is mildly enhanced by Mbs03802/+ (fewer bristles are formed).

The Rho1GMR.PH phenotype is partially suppressed by ParpGMR.PU; ommatidial lattices are seen in the rescued flies and pigment cells are seen in deeper regions of the retina. A distinct rhabdomere structure also appears.

Does not significantly alter the photoreceptor axon projection defects caused by expression of trioGEF1.GMR.T:Hsap\MYC.

Xenogenetic Interactions
Statement
Reference

Co-expression of Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4GMR.PF restores the eye morphology to wild type in Rho1GMR.PH flies.

The Hsap\RALAG23V.GMR eye phenotype is enhanced by Rho1GMR.PH; flies carrying one copy of either Hsap\RALAG23V.GMR or Rho1GMR.PH have a mild rough eye phenotype, while flies carrying both Hsap\RALAG23V.GMR and Rho1GMR.PH have extremely rough eyes with a glossy appearance due to the fusion of facets. A thin layer of pigment cells is seen in the apical region of the retina and no recognisable ommatidia can be seen.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Rho1GMR.PH
Name Synonyms
glass multimer reporter construct of Hariharan
Secondary FlyBase IDs
    References (17)