FlyBase Allele Report: Dmel\trio[GEF1.GMR.Tag:MYC]

General Information

Symbol

Dmel\trio^{GEF1.GMR.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0117295

Feature type

allele

Associated gene

Dmel\trio

Associated Insertion(s)

Carried in Construct

P{GMR-trio.GEF1}

Key Links

Transgenic product class

inframe_deletion

(Newsome et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Newsome et al., 2000)

Mutagen

in vitro construct

(Newsome et al., 2000)

Progenitor genotype

Carried in construct

P{GMR-trio.GEF1}

Cytology

Description

GMR regulatory sequences drive expression of the trio GEF1 domain tagged at the 3' end with 8 copies of the Tag:MYC tag.

(Newsome et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

trio

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Hakeda-Suzuki et al., 2002)

Phenotype Manifest In

eye

(Hakeda-Suzuki et al., 2002)

photoreceptor cell & axon

(Hakeda-Suzuki et al., 2002, Newsome et al., 2000)

Detailed Description

Statement

Reference

Flies expressing trio^{GEF1.GMR.T:Hsap\MYC} have severely disrupted eye morphology and highly aberrant photoreceptor axon projections.

(Hakeda-Suzuki et al., 2002)

Animals expressing trio^{GEF1.GMR.T:Hsap\MYC} show defects in photoreceptor axon projections.

(Newsome et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

trio^{GEF1.GMR.Tag:MYC} has visible phenotype, suppressible by Rac2^Δ/Rac2^Δ

(Hakeda-Suzuki et al., 2002)

trio^{GEF1.GMR.Tag:MYC} has visible phenotype, suppressible by Rac1^J10/Rac1^J10

(Hakeda-Suzuki et al., 2002)

NOT suppressed by

Statement

Reference

trio^{GEF1.GMR.Tag:MYC} has visible phenotype, non-suppressible by Mtl^Δ/Mtl^Δ

(Hakeda-Suzuki et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

trio^{GEF1.GMR.Tag:MYC} has phenotype, enhanceable by Mtl^GMR.PN

(Newsome et al., 2000)

trio^{GEF1.GMR.Tag:MYC} has photoreceptor cell & axon phenotype, enhanceable by Mtl^GMR.PN

(Newsome et al., 2000)

trio^{GEF1.GMR.Tag:MYC} has phenotype, enhanceable by Rac1^GMR.PNe

(Newsome et al., 2000)

trio^{GEF1.GMR.Tag:MYC} has photoreceptor cell & axon phenotype, enhanceable by Rac1^GMR.PNe

(Newsome et al., 2000)

NOT Enhanced by

Statement

Reference

trio^{GEF1.GMR.Tag:MYC} has phenotype, non-enhanceable by Cdc42^GMR.PN

(Newsome et al., 2000)

trio^{GEF1.GMR.Tag:MYC} has phenotype, non-enhanceable by Rho1^GMR.PH

(Newsome et al., 2000)

Suppressed by

Statement

Reference

trio^{GEF1.GMR.Tag:MYC} has photoreceptor cell & axon phenotype, suppressible by Rac2^Δ/Rac2^Δ

(Hakeda-Suzuki et al., 2002)

trio^{GEF1.GMR.Tag:MYC} has eye phenotype, suppressible by Rac1^J10/Rac1^J10

(Hakeda-Suzuki et al., 2002)

trio^{GEF1.GMR.Tag:MYC} has eye phenotype, suppressible by Rac2^Δ/Rac2^Δ

(Hakeda-Suzuki et al., 2002)

trio^{GEF1.GMR.Tag:MYC} has photoreceptor cell & axon phenotype, suppressible by Rac1^J10/Rac1^J10

(Hakeda-Suzuki et al., 2002)

NOT suppressed by

Statement

Reference

trio^{GEF1.GMR.Tag:MYC} has eye phenotype, non-suppressible by Mtl^Δ/Mtl^Δ

(Hakeda-Suzuki et al., 2002)

trio^{GEF1.GMR.Tag:MYC} has photoreceptor cell & axon phenotype, non-suppressible by Mtl^Δ/Mtl^Δ

(Hakeda-Suzuki et al., 2002)

trio^{GEF1.GMR.Tag:MYC} has phenotype, non-suppressible by Cdc42^GMR.PN

(Newsome et al., 2000)

trio^{GEF1.GMR.Tag:MYC} has phenotype, non-suppressible by Rho1^GMR.PH

(Newsome et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The photoreceptor axon projection defects caused by expression of trio^{GEF1.GMR.T:Hsap\MYC} are enhanced by Mtl^GMR.PN or Rac1^GMR.PNe.

(Newsome et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

trio^{GEF1.GMR.T:Hsap\MYC}

trio^{GEF1.GMR.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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