FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rac1GMR.PNe
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General Information
Symbol
Dmel\Rac1GMR.PNe
Species
D. melanogaster
Name
glass multimer reporter construct of Newsome
FlyBase ID
FBal0117667
Feature type
allele
Associated gene
Dmel\Rac1
Associated Insertion(s)
Carried in Construct
P{GMR-Rac1.Ne}
Key Links
Transgenic product class
cDNA
(Newsome et al., 2000)
wild_type
(Newsome et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Newsome et al., 2000)
wild_type
(Newsome et al., 2000)
Mutagen
in vitro construct
(Newsome et al., 2000)
Progenitor genotype
Carried in construct
P{GMR-Rac1.Ne}
Cytology
Description

GMR regulatory sequences drive expression of a Rac1 cDNA.

(Newsome et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
Rac1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Rac1GMR.PNe in a wild-type background does not disrupt photoreceptor axon projections.

      (Newsome et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Rac1GMR.PNe is an enhancer of phenotype of trioGEF1.GMR.Tag:MYC

      (Newsome et al., 2000)

      Rac1GMR.PNe is an enhancer of photoreceptor cell & axon phenotype of trioGEF1.GMR.Tag:MYC

      (Newsome et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mosaic flies in which the eye is triply mutant for MtlΔ, Rac1J10 and Rac2Δ show severe defects in the projection pattern of photoreceptor cell axons, showing a medulla bypass phenotype. The projection defects in the triple mutant eyes can be rescued by Rac1GMR.PNe.

      (Hakeda-Suzuki et al., 2002)

      Enhances the photoreceptor axon projection defects caused by expression of trioGEF1.GMR.T:Hsap\MYC.

      (Newsome et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rac1GMR.PNe
      Name Synonyms
      glass multimer reporter construct of Newsome
      (Newsome et al., 2000)
      Secondary FlyBase IDs
        References (2)