FlyBase Gene Report: Dmel\Dlc90F

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\Dlc90F

General Information

Symbol

Dmel\Dlc90F

Species

D. melanogaster

Name

Dynein light chain 90F

Annotation Symbol

CG12363

Feature Type

protein_coding_gene

FlyBase ID

FBgn0024432

Gene Model Status

Stock Availability

13 publicly available

Gene Summary

Dynein light chain 90F (Dlc90F) encodes a light chain subunit of the cytoplasmic dynein complex. The product of Dlc90F forms a dimer that assembles into the cytoplasmic dynein complex and is thought to link dynein to cargos and to adapter proteins that regulate dynein motor function. It contributes to male fertility. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Tctex-1, dynein light chain; tctex-1, Tctex1, Tctex

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:18,299,229..18,300,044 [+]

Recombination map

3-63

RefSeq locus

NT_033777 REGION:18299229..18300044

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables disordered domain specific binding

inferred from physical interaction with UniProtKB:Q24246

(Hall et al., 2009, Barbar and Hare, 2004, Makokha et al., 2002)

enables dynein intermediate chain binding

inferred from physical interaction with FLYBASE:sw; FB:FBgn0003654

(Song et al., 2007)

enables dynein light intermediate chain binding

inferred from direct assay

(Williams et al., 2007)

enables protein homodimerization activity

inferred from direct assay

(Song et al., 2007, Williams et al., 2007)

inferred from direct assay

(Hall et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables dynein intermediate chain binding

inferred from biological aspect of ancestor with PANTHER:PTN000478852

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in mitotic cell cycle

inferred from high throughput mutant phenotype

(Ducat et al., 2008)

involved_in retrograde axonal transport

inferred from mutant phenotype

(Yang et al., 2008)

involved_in spermatid development

inferred from mutant phenotype

(Li et al., 2004)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in microtubule-based movement

inferred from biological aspect of ancestor with PANTHER:PTN000478852

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of dynein complex

inferred from direct assay

(Williams et al., 2007)

part_of protein-containing complex

inferred from direct assay

(Hall et al., 2009, Barbar and Hare, 2004, Makokha et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of cytoplasmic dynein complex

inferred from biological aspect of ancestor with PANTHER:PTN000478852

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P51808

(Pfister et al., 2006)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000478852

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

DYNEIN LIGHT CHAINS

Protein Family (UniProt)

Belongs to the dynein light chain Tctex-type family. (Q94524)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Dynein light chain 90F (Dlc90F) encodes a light chain subunit of the cytoplasmic dynein complex. The product of Dlc90F forms a dimer that assembles into the cytoplasmic dynein complex and is thought to link dynein to cargos and to adapter proteins that regulate dynein motor function. It contributes to male fertility. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

DYNEIN LIGHT CHAINS -: Dyneins are minus end-directed microtubule motor protein complexes. Dynein light chains are involved in dynein complex assembly and interact with specific dynein adaptor proteins. (Adapted from PMID:19935668 and PMID:24064538).

Protein Function (UniProtKB)

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Required for spermatid differentiation. Is not required for polarized transport in rhabdomere development and appears to be a non-essential component of the cytoplasmic dynein complex.

(UniProt, Q94524)

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Dlc90F for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q94524)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0083575

816

111

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0082996

12.5

111

4.79

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

111 (aa)

(Caggese et al., 1999)

Comments

External Data

Subunit Structure (UniProtKB)

The cytoplasmic dynein complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).

(UniProt, Q94524)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dlc90F using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dlc90F_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.29

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of dynein complex

inferred from direct assay

(Williams et al., 2007)

part_of protein-containing complex

inferred from direct assay

(Hall et al., 2009, Barbar and Hare, 2004, Makokha et al., 2002)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dlc90F in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dlc90F

View exonic expression by tissue for Dmel\Dlc90F

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024432

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42199/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024432

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024432

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024432

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12363

Flygut - An atlas of the Drosophila adult midgut

FBgn0024432

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dlc90F

Transgenic constructs containing regulatory region of Dlc90F

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

(Caggese et al., 2001)

(Li et al., 2004)

Df(3R)Dlc90F^12.2

(Caggese et al., 2001)

Df(3R)Dlc90F^19.1

(Caggese et al., 2001)

(Ryder, 2004.4.26)

Gene not disrupted in

(BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die

Dlc90F⁰⁴⁰⁹¹

partially lethal - majority die | recessive

Dlc90F⁰⁴⁰⁹¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dlc90F^GD7584

viable, with Scer\GAL4^Mef2.PR

Dlc90F^GD7584

viable, with Scer\GAL4^pnr-MD237

Dlc90F^GD7584

viable, with Scer\GAL4^tin.CΔ4

Dlc90F^GD7584

viable (with Df(3R)DG2)

Sterility

Allele

male semi-sterile | recessive

Dlc90F^EP3634

Dlc90F⁰⁵⁰⁸⁹

male sterile | recessive

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Dlc90F^GD7584

long lived, with Scer\GAL4^da.Switch.PT

Dlc90F^GX48290

visible, with Scer\GAL4^pnr-MD237

Dlc90F^GD7584

Phenotype manifest in

Allele

centrosome (with Df(3R)Exel6178)

Dlc90F^e155

mesonotum, with Scer\GAL4^pnr-MD237

Dlc90F^GD7584

Nebenkern (with Df(3R)Exel6178)

Dlc90F^e155

Dlc90F^e155

spermatocyte (with Df(3R)Exel6178)

Dlc90F^e155

trichogen cell, with Scer\GAL4^pnr-MD237

Dlc90F^GD7584

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

14 of 14

Yes

Yes

1

7 of 14

No

Yes

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (8)

14 of 14

Yes

Yes

7 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Rnor\LOC100294508

1 of 14

No

No

Rnor\RGD1307443

1 of 14

No

No

Rnor\RGD1564702

1 of 14

No

No

Mus musculus (laboratory mouse) (14)

14 of 14

Yes

Yes

14 of 14

Yes

Yes

14 of 14

Yes

Yes

13 of 14

No

Yes

7 of 14

No

Yes

1 of 14

No

No

Mmus\D130043K22Rik

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (6)

11 of 13

Yes

Yes

2 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xtro\LOC100495666

1 of 13

No

No

Xtro\LOC100498184

1 of 13

No

No

Danio rerio (Zebrafish) (8)

14 of 14

Yes

Yes

9 of 14

No

Yes

6 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (3)

11 of 14

Yes

Yes

5 of 14

No

Yes

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP001229

12 of 12

Yes

Yes

Agam\AgaP_AGAP005171

1 of 12

No

No

Agam\AgaP_AGAP005179

1 of 12

No

No

Agam\AgaP_AGAP007597

1 of 12

No

No

Agam\AgaP_AGAP009318

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

7 of 12

Yes

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dlc90F. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

3 of 13

3 of 13

3 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DYNLT1; dynein light chain Tctex-type 1

14 of 14

DYNLT3; dynein light chain Tctex-type 3

7 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

x-ray crystallography, two hybrid

(Hu et al., 2017.6.13, Williams et al., 2005)

experimental knowledge based

(Guruharsha et al., 2011)

Dlc90F - Arpc3A

experimental knowledge based

(Guruharsha et al., 2011)

Dlc90F - CG14763

experimental knowledge based

(Guruharsha et al., 2011)

Dlc90F - CG2267

(Hu et al., 2017.6.13)

Dlc90F - CG33672

(Hu et al., 2017.6.13)

Dlc90F - CG42232

experimental knowledge based

(Guruharsha et al., 2011)

Dlc90F - Hsp67Bc

(Hu et al., 2017.6.13)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

(Hu et al., 2017.6.13)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Dlc90F - Strn-Mlck

(Hu et al., 2017.6.13)

experimental knowledge based

(Guruharsha et al., 2011)

(Hu et al., 2017.6.13)

molecular sieving, predetermined participant

(Hall et al., 2010)

experimental knowledge based

(Guruharsha et al., 2011)

molecular sieving, predetermined participant

(Hall et al., 2010)

experimental knowledge based

(Guruharsha et al., 2011)

circular dichroism, predetermined participant, nuclear magnetic resonance, molecular sieving, pull down, molecular weight estimation by staining

(Hall et al., 2010, Song et al., 2007, Benison et al., 2006, Makokha et al., 2002)

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Zhu et al., 2005)

enhanceable

(Zhu et al., 2005)

suppressible

(Neuert et al., 2017)

suppressible

(Gregory et al., 2007)

enhanceable

(Gregory et al., 2007)

enhanceable

(Zhu et al., 2005)

External Data

Subunit Structure (UniProtKB)

The cytoplasmic dynein complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).

(UniProt, Q94524 )

Linkouts

BioGRID - A database of protein and genetic interactions.

67217

DroID - A comprehensive database of gene and protein interactions.

FBgn0024432

MIST (genetic) - An integrated Molecular Interaction Database

42199

MIST (protein-protein) - An integrated Molecular Interaction Database

42199

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-63

Cytogenetic map

Sequence location

3R:18,299,229..18,300,044 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

91A2-91A2

Limits computationally determined from genome sequence between P{EP}cpo^EP3679 and P{EP}Dlc90F^EP3634

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

90F9-91A2

(Caggese, 1999.1.22)

90F1-90F11

(Caggese, 1996.10.21)

90F9-90F11

(determined by in situ hybridisation)

(Caggese et al., 1999)

90F-90F

(Li et al., 1998)

91A1-91A2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-63

(FlyBase, 2016)

3-62.3

(Comeron et al., 2012)

3-

(Caggese, 1996.10.21)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

85118

w¹¹¹⁸; PBac{RB}Dlc90F^e00877/TM6B, Tb¹

656

P{PZ}sdl^05090a ry⁵⁰⁶ P{PZ}Dlc90F^05090b/MKRS

65189

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06064}attP40

11623

ry⁵⁰⁶ P{PZ}Dlc90F⁰⁴⁰⁹¹/TM3, ry^RK Sb¹ Ser¹

11646

ry⁵⁰⁶ P{PZ}Dlc90F⁰⁵⁰⁸⁹/TM3, ry^RK Sb¹ Ser¹

14912

y¹; ry⁵⁰⁶ P{SUPor-P}Dlc90F^KG06855/TM3, Sb¹ Ser¹

11588

P{EP}Dlc90F^G15344

105479

y^* w^*; P{GawB}Dlc90F^NP7472 / TM6, P{UAS-lacZ.UW23-1}UW23-1

200477

y¹ w^67c23; P{GSV1}Dlc90F^GS3099/TM3, Sb¹ Ser¹

202891

y¹ w^67c23; P{GSV6}Dlc90F^GS10880/TM3, Sb¹ Ser¹

v31749

w¹¹¹⁸; P{GD7584}v31749/CyO

v31750

w¹¹¹⁸; P{GD7584}v31750/TM3

More stocks available...

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (34)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD36705

Other clones

DPiM_LD36705

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0024432

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0024432

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Dlc90F appears to be distinct from other dynein subunits as it is not required for any essential functions in the organism, but only appears to be neccessary in spermatogenesis.

(Li et al., 2004)

Dlc90F is required for production of functional sperms.

(Caggese, 1999.5.14)

Southern blot analysis indicates that Dlc90F is encoded by a single copy gene and is expressed as a single transcript throughout Drosophila development. Western blot experiments show that the 14kD light chain is co-purified with cytoplasmic dynein from embryos and there exist two isoforms, suggesting a post-translational regulation of the light chain.

(Li et al., 1998)

Lethal lines have been obtained by imprecise excision of a P-element inserted 800bp upstream of the transcription start site of Dlc90F.

(Li et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: Tctex l(3)04091

(Caggese, 1999.5.14)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG12363

(Ibaraki et al., 2021, Ward and Moehring, 2021, Neuert et al., 2017, Çiçek et al., 2016, Perkins et al., 2009, Ducat et al., 2008, Wickstead and Gull, 2007, Lee et al., 2003, Goldstein and Gunawardena, 2000)

Dynein

(Padilla et al., 2022)

TcTex-1

(Williams et al., 2007, Williams et al., 2005)

Tctex

(Caggese, 1999.5.14, Caggese et al., 1999)

Tctex-1

(Fabian and Brill, 2012, Mische et al., 2008, Song et al., 2007, Benison et al., 2006, Barbar and Hare, 2004, Makokha et al., 2002, Pursifull et al., 2002, Steele et al., 2002)

Tctex1

(Nyarko and Barbar, 2011, Hall et al., 2010, Hall et al., 2009)

bs35g12.y1

(Andrews et al., 2000)

dlc90F

(Wang et al., 2008)

dtctex-1

(Caggese et al., 2001)

l(3)04091

tctex

(Caggese, 1996.10.21)

tctex-1

(Fabian and Brill, 2012, Sitaram et al., 2012, Li et al., 2004, Goldstein and Gunawardena, 2000, Caggese, 1999.1.22, Caggese et al., 1999)

Name Synonyms

Dynein light chain 90F

(Paik et al., 2012, Ducat et al., 2008, Gregory et al., 2007, Li et al., 1998)

dynein light chain; tctex-1

(Caggese, 1999.7.25, Caggese, 1999.7.25, Caggese, 1999.7.25)

Secondary FlyBase IDs

FBgn0010833
FBgn0017467

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42199

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q94524

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q94524

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q94524

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024432

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42199/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024432

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024432

FlyMine - An integrated database for Drosophila genomics

FBgn0024432

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12363

MARRVEL_MODEL - MARRVEL (model organism gene)

42199

PDB - An information portal to biological macromolecular structures

Linkouts

BioGRID - A database of protein and genetic interactions.

67217

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0024432

DroID - A comprehensive database of gene and protein interactions.

FBgn0024432

DRSC - Results frm RNAi screens

FBgn0024432

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dlc90F_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024432

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0024432

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12363

Flygut - An atlas of the Drosophila adult midgut

FBgn0024432

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0024432

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009745

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

MIST (genetic) - An integrated Molecular Interaction Database

42199

MIST (protein-protein) - An integrated Molecular Interaction Database

42199

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

References (99)