FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\CycB3
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General Information
Symbol
Dmel\CycB3
Species
D. melanogaster
Name
Cyclin B3
Annotation Symbol
CG5814
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015625
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
Cyclin B3 (CycB3) encodes a protein that binds to the product of Cdk1, presumably promoting Cdk1's protein kinase activity. The complex CycB3-Cdk1 cooperates with other Cdk1 complexes (CycA-Cdk1 and CycB-Cdk1) to promote the G2/M transition. Like the products of CycA and CycB, the product of CycB3 is also rapidly degraded during exit from mitosis and during G1. It appears to have a specific role in activating the APC/C-dependent degradation pathway. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)L6540

Key Links
Genomic Location
Cytogenetic map
96B1-96B1
Sequence location
Recombination map
3-86
RefSeq locus
NT_033777 REGION:24867934..24870816
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:P23572
(Jacobs et al., 1998)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables cyclin-dependent protein serine/threonine kinase regulator activity
inferred from electronic annotation with InterPro:IPR046965
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(GO Reference Genome Project, 2011-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in mitotic cell cycle
inferred from direct assay
(Parry and O'Farrell, 2001)
involved_in mitotic cytokinesis
inferred from direct assay
(Echard and O'Farrell, 2003)
inferred from mutant phenotype
(Echard and O'Farrell, 2003)
inferred from direct assay
(Parry and O'Farrell, 2001)
involved_in syncytial blastoderm mitotic cell cycle
inferred from genetic interaction with FLYBASE:CycA; FB:FBgn0000404,FLYBASE:CycB; FB:FBgn0000405
(McCleland and O'Farrell, 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in G1/S transition of mitotic cell cycle
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(GO Reference Genome Project, 2011-)
involved_in mitotic cell cycle phase transition
inferred from electronic annotation with InterPro:IPR046965
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Jacobs et al., 1998)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of cyclin-dependent protein kinase holoenzyme complex
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(GO Reference Genome Project, 2011-)
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000019791
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cyclin family. Cyclin AB subfamily. (Q9I7I0)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cyclin B3 (CycB3) encodes a protein that binds to the product of Cdk1, presumably promoting Cdk1's protein kinase activity. The complex CycB3-Cdk1 cooperates with other Cdk1 complexes (CycA-Cdk1 and CycB-Cdk1) to promote the G2/M transition. Like the products of CycA and CycB, the product of CycB3 is also rapidly degraded during exit from mitosis and during G1. It appears to have a specific role in activating the APC/C-dependent degradation pathway. [Date last reviewed: 2019-03-21]
Protein Function (UniProtKB)
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Probably functions redundantly with other cyclins in regulation of cell cycle. Its presence may be required to delay a deadline for completing cytokinesis that is ordinary imposed by nuclear envelope reformation. Degradation of CycB and CycB3 promote cytokinesis furrow initiation and ingression. Required with CycB for female fertility.
(UniProt, Q9I7I0)
Summary (Interactive Fly)

an activator of the Cdk1 that is required for mitotic and meiotic anaphase - required for germline stem cell maintenance - required for anaphase progression in meiosis I and in meiosis II - plays a redundant role with Cyclin A in preventing DNA replication during meiosis

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CycB3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9I7I0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CycB3-RA
FBtr0084728
NM_143046
2461
575
CycB3-RB
FBtr0334578
NM_001276005
2883
575
Additional Transcript Data and Comments
Reported size (kB)

2.7 (northern blot)

(Jacobs et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
CycB3-PA
FBpp0084103
64.8
575
9.11
Q9I7I0
NP_651303
AAG22169
CycB3-PB
FBpp0306645
64.8
575
9.11
Q9I7I0
NP_001262934
AGB96314
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

575 aa isoforms: CycB3-PA, CycB3-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

575 (aa)

(Jacobs et al., 1998)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Cdk1 kinase.

(UniProt, Q9I7I0)
Post Translational Modification

Ubiquitinated (Probable). Ubiquitination leads to its degradation in early anaphase.

(UniProt, Q9I7I0)
Domain

The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.

(UniProt, Q9I7I0)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CycB3 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.50

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal sensory complex primordium
(Fisher et al., 2012)
gnathal primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic central brain surface glial cell
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval lateral VNC surface glial cell
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 15
ventral nerve cord
(Magalhaes et al., 2007)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Jacobs et al., 1998)
neuroblast
(Jacobs et al., 1998)
pre-blastoderm stage
organism
(Jacobs et al., 1998)
adult stage | female
(Jacobs et al., 1998)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 8
neuroblast of ventral nervous system

Comment: dividing neuroblasts

(Chang et al., 2000)
embryonic stage 11
neuroblast of ventral nervous system | medial

Comment: dividing neuroblasts

(Chang et al., 2000)
Additional Descriptive Data

At embryonic stage 8, CycB3 protein is expressed in eight longitudinal columns of ectodermal cells in the ventral neurogenic region. By stage 11, CycB3@ protein is expressed in cells medial to the ventral midline.

(Chang et al., 2000, Jacobs et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Jacobs et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CycB3 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CycB3
Transgenic constructs containing regulatory region of CycB3
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(3R)Exel6200
(Ryder, 2004.4.26)
Df(3R)XTA1
(Jacobs et al., 1998)
Gene not disrupted in
Df(3R)XTA1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Gene partially disrupted in
Df(3R)96ST
(Zhang et al., 2005)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (19)
Hsap\CCNB3
8 of 14
Yes
Yes
Hsap\CCNA1
4 of 14
No
No
Hsap\CCNA2
4 of 14
No
No
Hsap\CCNB1
4 of 14
No
No
1  
Hsap\CCNB2
4 of 14
No
No
1  
Hsap\CCNE1
3 of 14
No
No
1  
Hsap\CCNE2
3 of 14
No
No
1  
Hsap\CCNJL
3 of 14
No
No
Hsap\CCNF
2 of 14
No
No
Hsap\CCNG1
2 of 14
No
No
Hsap\CCNG2
2 of 14
No
No
1  
Hsap\CCNI2
2 of 14
No
No
Hsap\CCNI
2 of 14
No
No
1  
Hsap\CCNJ
2 of 14
No
No
1  
Hsap\CCNO
2 of 14
No
No
Hsap\CCNP
2 of 14
No
No
Hsap\CCND1
1 of 14
No
No
Hsap\CCND2
1 of 14
No
No
1  
Hsap\CCND3
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (18)
Rnor\Ccnb3
8 of 14
Yes
Yes
Rnor\Ccna1
4 of 14
No
No
Rnor\Ccna2
4 of 14
No
No
Rnor\Ccnb1
3 of 14
No
No
Rnor\Ccne1
3 of 14
No
No
Rnor\Ccne2
3 of 14
No
No
Rnor\Ccnjl
3 of 14
No
No
Rnor\Ccng1
2 of 14
No
No
Rnor\Ccng2
2 of 14
No
No
Rnor\Ccni
2 of 14
No
No
Rnor\Ccnj
2 of 14
No
No
Rnor\Ccno
2 of 14
No
No
Rnor\Ccnb2
1 of 14
No
Yes
Rnor\Ccnd1
1 of 14
No
No
Rnor\Ccnd2
1 of 14
No
No
Rnor\Ccnd3
1 of 14
No
No
Rnor\Ccnf
1 of 14
No
No
Rnor\LOC100364016
1 of 14
No
Yes
Mus musculus (laboratory mouse) (17)
Mmus\Ccnb3
8 of 14
Yes
Yes
Mmus\Ccna1
4 of 14
No
No
Mmus\Ccnb1
4 of 14
No
No
Mmus\Ccnb2
4 of 14
No
No
Mmus\Ccna2
3 of 14
No
No
Mmus\Ccne1
3 of 14
No
No
Mmus\Ccne2
3 of 14
No
No
Mmus\Ccnjl
3 of 14
No
No
Mmus\Ccnf
2 of 14
No
No
Mmus\Ccng1
2 of 14
No
No
Mmus\Ccng2
2 of 14
No
No
Mmus\Ccni
2 of 14
No
No
Mmus\Ccnj
2 of 14
No
No
Mmus\Ccno
2 of 14
No
No
Mmus\Ccnd1
1 of 14
No
No
1  
Mmus\Ccnd2
1 of 14
No
No
Mmus\Ccnd3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (31)
Xtro\ccnb3
9 of 13
Yes
Yes
Xtro\ccnb1
3 of 13
No
No
Xtro\ccnb2
3 of 13
No
No
Xtro\LOC394448
3 of 13
No
No
Xtro\ap3b2
2 of 13
No
No
Xtro\ccna1
2 of 13
No
No
Xtro\ccna2
2 of 13
No
No
Xtro\ccnb1.2
2 of 13
No
No
Xtro\ccne1
2 of 13
No
No
Xtro\ccne2
2 of 13
No
No
Xtro\ripply2.1
2 of 13
No
No
Xtro\ccndx
1 of 13
No
No
Xtro\ccnf
1 of 13
No
No
Xtro\ccng1
1 of 13
No
No
Xtro\ccng2
1 of 13
No
No
Xtro\ccni2
1 of 13
No
Yes
Xtro\ccni
1 of 13
No
No
Xtro\ccnj
1 of 13
No
No
Xtro\foxred1
1 of 13
No
No
Xtro\LOC100487999
1 of 13
No
No
Xtro\LOC100493210
1 of 13
No
Yes
Xtro\LOC101730848
1 of 13
No
No
Xtro\LOC105946681
1 of 13
No
No
Xtro\LOC105948063
1 of 13
No
Yes
Xtro\LOC116406785
1 of 13
No
No
Xtro\rbpms2
1 of 13
No
No
Xtro\rsad1
1 of 13
No
No
Xtro\tm4sf4
1 of 13
No
Yes
Xtro\XB940382
1 of 13
No
Yes
Xtro\XB997834
1 of 13
No
No
Xtro\zmpste24
1 of 13
No
No
Danio rerio (Zebrafish) (20)
Drer\ccnb3
12 of 14
Yes
Yes
Drer\ccna1
4 of 14
No
No
Drer\ccna2
4 of 14
No
No
Drer\ccnb1
4 of 14
No
No
Drer\ccnb2
4 of 14
No
No
Drer\ccne1
2 of 14
No
No
Drer\ccne2
2 of 14
No
No
Drer\ccng1
2 of 14
No
No
Drer\ccng2
2 of 14
No
No
Drer\ccni2
2 of 14
No
No
Drer\ccni
2 of 14
No
No
Drer\ccnj
2 of 14
No
No
Drer\ccnjl
2 of 14
No
No
Drer\ccnp
2 of 14
No
No
Drer\ccnd1
1 of 14
No
No
Drer\ccnd2a
1 of 14
No
No
Drer\ccnd2b
1 of 14
No
No
Drer\ccnd3
1 of 14
No
No
Drer\ccndx
1 of 14
No
No
Drer\ccno
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (18)
Cele\cyb-3
10 of 14
Yes
Yes
Cele\cya-1
4 of 14
No
No
Cele\cyb-1
4 of 14
No
No
Cele\cyb-2.1
4 of 14
No
No
Cele\cyb-2.2
4 of 14
No
No
Cele\cya-2
3 of 14
No
Yes
Cele\F08F1.9
3 of 14
No
Yes
Cele\cye-1
2 of 14
No
No
Cele\T07F10.5
2 of 14
No
Yes
Cele\T24A6.1
2 of 14
No
No
Cele\W05G11.2
2 of 14
No
Yes
Cele\ZK678.3
2 of 14
No
Yes
Cele\C02B8.1
1 of 14
No
Yes
Cele\C03B8.2
1 of 14
No
Yes
Cele\C04C3.4
1 of 14
No
Yes
Cele\cyd-1
1 of 14
No
No
Cele\R02F2.1
1 of 14
No
Yes
Cele\T12C9.7
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP002478
10 of 12
Yes
Yes
Agam\AgaP_AGAP004962
4 of 12
No
No
Agam\AgaP_AGAP004963
4 of 12
No
No
Agam\AgaP_AGAP012413
4 of 12
No
No
Agam\AgaP_AGAP002532
3 of 12
No
No
Agam\AgaP_AGAP001730
2 of 12
No
No
Agam\AgaP_AGAP008191
2 of 12
No
No
Agam\AgaP_AGAP012299
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (33)
Atha\CYCB1;4
7 of 13
Yes
No
Atha\CYC3B
6 of 13
No
No
Atha\CYCA1;1
6 of 13
No
No
Atha\CYCA1;2
6 of 13
No
No
Atha\CYCA2;1
6 of 13
No
No
Atha\CYCA2;3
6 of 13
No
No
Atha\CYCA2;4
6 of 13
No
No
Atha\CYCA3;1
6 of 13
No
No
Atha\CYCA3;2
6 of 13
No
No
Atha\CYCA3;3
6 of 13
No
No
Atha\CYCA3;4
6 of 13
No
No
Atha\AT1G20590
5 of 13
No
No
Atha\CYC1BAT
5 of 13
No
No
Atha\CYCB1;1
5 of 13
No
No
Atha\CYCB1;3
5 of 13
No
No
Atha\CYCB1;5
5 of 13
No
No
Atha\CYCB2;1
5 of 13
No
No
Atha\CYCB2;2
5 of 13
No
No
Atha\CYCB2;3
5 of 13
No
No
Atha\CYCB2;4
5 of 13
No
No
Atha\CYCB3;1
5 of 13
No
No
Atha\SDS
3 of 13
No
Yes
Atha\CYCD1;1
2 of 13
No
No
Atha\CYCD3;1
2 of 13
No
No
Atha\CYCD3;2
2 of 13
No
No
Atha\CYCD3;3
2 of 13
No
No
Atha\CYCD4;2
2 of 13
No
No
Atha\CYCD5;1
2 of 13
No
No
Atha\CYCD6;1
2 of 13
No
No
Atha\CYCD2;1
1 of 13
No
No
Atha\CYCD4;1
1 of 13
No
No
Atha\CYCD7;1
1 of 13
No
No
Atha\CYCJ18
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\CLB1
7 of 13
Yes
No
Scer\CLB2
7 of 13
Yes
No
Scer\CLB5
7 of 13
Yes
Yes
Scer\CLB6
7 of 13
Yes
Yes
Scer\CLB3
4 of 13
No
No
Scer\CLB4
4 of 13
No
No
Scer\CLN1
4 of 13
No
Yes
Scer\CLN2
4 of 13
No
Yes
Scer\CLN3
3 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\cdc13
6 of 12
Yes
No
Spom\cig2
6 of 12
Yes
No
Spom\cig1
5 of 12
No
No
Spom\puc1
3 of 12
No
No
Spom\rem1
3 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:CycB3. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
CycB
8 of 13
CycA
6 of 13
CycE
5 of 13
CycJ
4 of 13
CycD
3 of 13
CycG
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CCNB3; cyclin B3
    8 of 14
    300456
        CCNA1; cyclin A1
        4 of 14
        604036
            CCNA2; cyclin A2
            4 of 14
            123835
                CCNB1; cyclin B1
                4 of 14
                123836
                     
                    CCNB2; cyclin B2
                    4 of 14
                    602755
                         
                        CCNE1; cyclin E1
                        3 of 14
                        123837
                             
                            CCNE2; cyclin E2
                            3 of 14
                            603775
                                 
                                CCNJL; cyclin J like
                                3 of 14
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    Summary of Genetic Interactions
                                    Interaction Browsers
                                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                                    Please look at the allele data for full details of the genetic interactions
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    CycB3
                                    enhanceable
                                    pbl
                                    (Echard and O'Farrell, 2003)
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    fzr
                                    suppressible
                                    CycB3
                                    (Neuert et al., 2017)
                                    H
                                    enhanceable
                                    CycB3
                                    (Johannes and Preiss, 2002)
                                    pbl
                                    suppressible
                                    CycB3
                                    (Echard and O'Farrell, 2003)
                                    pbl
                                    suppressible
                                    CycB3|CycB
                                    (Gregory et al., 2007)
                                    pbl
                                    enhanceable
                                    CycB3
                                    (Echard and O'Farrell, 2003)
                                    png
                                    suppressible
                                    CycB3
                                    (Lee et al., 2001)
                                    External Data
                                    Subunit Structure (UniProtKB)
                                    Interacts with Cdk1 kinase.
                                    (UniProt, Q9I7I0 )
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    DroID - A comprehensive database of gene and protein interactions.
                                    MIST (genetic) - An integrated Molecular Interaction Database
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    FlyBase
                                    External Links
                                    External Data
                                    Linkouts
                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                    Class of Gene
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    3R
                                    Recombination map
                                    3-86
                                    Cytogenetic map
                                    96B1-96B1
                                    Sequence location
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    96B1-96B1
                                    Limits computationally determined from genome sequence between P{PZ}crb07207&P{PZ}BRWD305842 and P{EP}CycB3EP3127;
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    96B-96B
                                    (Jacobs, 1998.4.25)
                                    96B3-96B5
                                    (determined by in situ hybridisation)
                                    (Spradling et al., 1999)
                                    96B2-96B6
                                    (determined by in situ hybridisation)
                                    (Jacobs et al., 1998)
                                    96B3-96B5
                                    (BDGP Project Members, 1994-1999)
                                    Experimentally Determined Recombination Data
                                    Location

                                    3-86

                                    (FlyBase, 2016)

                                    3-84.8

                                    (Comeron et al., 2012)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (18)
                                    Genomic Clones (18)
                                     

                                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                    cDNA Clones (318)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                    Other clones
                                    Drosophila Genomics Resource Center cDNA clones

                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                    cDNA Clones, End Sequenced (ESTs)
                                    BDGP DGC clones
                                    Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    DRSC - Results frm RNAi screens
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     

                                    polyclonal

                                    (Jacobs et al., 1998)
                                    Commercially Available Antibodies
                                     
                                    Cell Line Information
                                    Publicly Available Cell Lines
                                     
                                      Other Stable Cell Lines
                                       
                                        Other Comments

                                        Temporal coordination of mitotic events involves inhibition of cytokinesis by CycB and CycB3 and punctual relief of inhibition by destruction of these Cyclins.

                                        (Echard and O'Farrell, 2003)

                                        Area matching Drosophila EST AA950161. This EST forms a 1217bp EST contig with AA950864 and AA950181.

                                        (Davies, 2001.3.15)

                                        CycB3 degradation is required for proper spindle reorganisation and restoration of the interphase nucleus.

                                        (Parry and O'Farrell, 2001)

                                        CycB3 is nuclear and present in mitotically proliferating cells and not in endoreplicating tissues. CycB3 associates with cdc2 but not cdc2c and is degraded during mitosis.

                                        (Jacobs et al., 1998)

                                        Double and triple mutant analyses show that CycB3, CycB and CycA cooperate during mitosis. CycB3 and CycB are not essential for viability.

                                        (Jacobs et al., 1998)

                                        Mutations in fzy result in metaphase arrest, neither CycA, CycB or CycB3 are degraded in this arrest. Comparison of the fzy mutant phenotype with the phenotype resulting from expression of N-terminal truncated CycA, CycB or CycB3 suggests that fzy is not only required for mitotic cyclin degradation because fzy mutations, but not truncated cyclins, block chromosome separation.

                                        (Sigrist et al., 1995)
                                        Relationship to Other Genes
                                        Source for database merge of

                                        Source for merge of: CycB3 l(3)L6540

                                        (Jacobs et al., 1998)

                                        Source for merge of: CycB3 anon-WO0118547.414

                                        (FlyBase, 1996-)
                                        Additional comments

                                        The CycB3 gene may have been derived from the CycA gene by retroposition.

                                        (Pan and Zhang, 2009)

                                        Source for merge of CycB3 anon-WO0118547.414 was sequence comparison ( date:051113 ).

                                        (FlyBase, 1996-)
                                        Nomenclature History
                                        Source for database identify of

                                        Source for identity of: CycB3 CG5814

                                        (Kodira, 1999.11)
                                        Nomenclature comments
                                        Etymology
                                        Synonyms and Secondary IDs (9)
                                        Reported As
                                        Symbol Synonym
                                        CG5814
                                        (Neuert et al., 2017, Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Pan and Zhang, 2009)
                                        Cyc B3
                                        (McCleland and O'Farrell, 2008)
                                        CycB3
                                        (Bourouh et al., 2024, Beaver et al., 2022, Chen et al., 2022, Ferguson et al., 2021, Fast et al., 2020, Garrido et al., 2020, Archambault, 2019.12.8, Liao et al., 2019, Park et al., 2019, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Bourouh et al., 2016, Das et al., 2016, Kong et al., 2016, Bergman et al., 2015, Kohlmaier et al., 2015, Wang and Baker, 2015, dos Santos, 2014, Liang et al., 2014, Bonke et al., 2013, Neumüller et al., 2013, Schertel et al., 2013, Farrell et al., 2012, Paik et al., 2012, Swaminathan et al., 2010, Althoff et al., 2009, McCleland et al., 2009, Buszczak et al., 2007, Gawlinski et al., 2007, Magalhaes et al., 2007, Swan and Schupbach, 2007, Tanaka-Matakatsu et al., 2007, Khurana et al., 2006, Mukherjee et al., 2006, Bauer et al., 2005, De Lucia et al., 2005, Greene et al., 2005, Liu et al., 2005, Zhang et al., 2005, Jacobs et al., 1998)
                                        Cyclin B3
                                        (Zhu et al., 2018)
                                        anon-WO0118547.414
                                        cycB3
                                        (Chen et al., 2018, Jahanshahi et al., 2016, Chen et al., 2009, Ji et al., 2002, Lee et al., 2001, Jacobs, 1998.4.25, Jacobs, 1998.11.6)
                                        l(3)L6540
                                        (Johannes and Preiss, 2002, Spradling et al., 1999)
                                        Name Synonyms
                                        CycB3
                                        Cyclin B3
                                        (Bakshi et al., 2023, Ko et al., 2023, Papoulas et al., 2010, Swaminathan et al., 2010, Gregory et al., 2007, Pesin and Orr-Weaver, 2007, Swan and Schupbach, 2007, Khurana et al., 2006, Reber et al., 2006, Heidmann et al., 2004, O'Farrell, 2001, Jacobs et al., 1998)
                                        CyclinB3
                                        (Mukherjee et al., 2006)
                                        cyclin B3
                                        (Karasu et al., 2019, Liao et al., 2019, Liu and Grosshans, 2017, Eichhorn et al., 2016, Zhan et al., 2013, Baldinger and Gossen, 2009, Chen et al., 2009, McCleland and O'Farrell, 2008, Gregory et al., 2007, Echard and O'Farrell, 2003, Lee and Orr-Weaver, 2003, Nieduszynski et al., 2002, Secombe et al., 1998)
                                        Secondary FlyBase IDs
                                        • FBgn0024564
                                        • FBgn0062026
                                        Datasets (0)
                                        Study focus (0)
                                        Experimental Role
                                        Project
                                        Project Type
                                        Title
                                        Study result (0)
                                        Result
                                        Result Type
                                        Title
                                        External Crossreferences and Linkouts ( 49 )
                                        Sequence Crossreferences
                                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                        Other crossreferences
                                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                        FlyMine - An integrated database for Drosophila genomics
                                        InterPro - A database of protein families, domains and functional sites
                                        KEGG Genes - Molecular building blocks of life in the genomic space.
                                        MARRVEL_MODEL - MARRVEL (model organism gene)
                                        Linkouts
                                        BioGRID - A database of protein and genetic interactions.
                                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                        DroID - A comprehensive database of gene and protein interactions.
                                        DRSC - Results frm RNAi screens
                                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                        Flygut - An atlas of the Drosophila adult midgut
                                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                        MIST (genetic) - An integrated Molecular Interaction Database
                                        MIST (protein-protein) - An integrated Molecular Interaction Database
                                        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                        References (147)