FlyBase Gene Report: Dmel\CycD

General Information

Symbol

Dmel\CycD

Species

D. melanogaster

Name

Cyclin D

Annotation Symbol

CG9096

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010315

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

Cyclin D (CycD) encodes a protein that binds to the product of Cdk4, thereby promoting its kinase activity. The CycD-Cdk4 complex promotes cell growth and progression through the G1 phase - it phosphorylates and thereby inhibits the product of Rbf, the ortholog of the human tumor suppressor retinoblastoma protein. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Interactive Fly

Also Known As

dCycD, Cdi3

Key Links

Genomic Location

Cytogenetic map

13F18-14A1

Sequence location

X:15,906,822..15,909,676 [-]

Recombination map

1-52

RefSeq locus

NC_004354 REGION:15906822..15909676

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cyclin-dependent protein serine/threonine kinase regulator activity

inferred from direct assay

(Finley et al., 1996)

enables protein binding

inferred from physical interaction with FLYBASE:Cdk4; FB:FBgn0016131

(Meyer et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables cyclin-dependent protein serine/threonine kinase regulator activity

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in positive regulation of cell growth

inferred from mutant phenotype

(Frei et al., 2005, Emmerich et al., 2004)

inferred from genetic interaction with FLYBASE:Cdk4; FB:FBgn0016131

(Datar et al., 2000)

involved_in positive regulation of receptor signaling pathway via JAK-STAT

inferred from genetic interaction with FLYBASE:upd1; FB:FBgn0004956,FLYBASE:Cdk4; FB:FBgn0016131

(Chen et al., 2003)

involved_in positive regulation of TORC1 signaling

inferred from mutant phenotype

(Kim et al., 2017)

inferred from genetic interaction with FLYBASE:E2f1; FB:FBgn0011766,FLYBASE:Cdk4; FB:FBgn0016131

(Kim et al., 2017)

inferred from genetic interaction with FLYBASE:Cdk4; FB:FBgn0016131

(Kim et al., 2017)

involved_in regulation of mitochondrion organization

inferred from genetic interaction with FLYBASE:Ets97D; FB:FBgn0004510,FLYBASE:Cdk4; FB:FBgn0016131

(Baltzer et al., 2009)

inferred from mutant phenotype

(Frei et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in G1/S transition of mitotic cell cycle

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

involved_in positive regulation of G1/S transition of mitotic cell cycle

inferred from biological aspect of ancestor with PANTHER:PTN000808639

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

part_of cyclin-dependent protein kinase holoenzyme complex

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

is_active_in microtubule organizing center

inferred from biological aspect of ancestor with PANTHER:PTN007424001

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000019791

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pathway (FlyBase)

POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY -: Positive regulators of JAK-STAT signaling up-regulate the pathway, enhancing transcriptional control by Stat92E.

Summary (Interactive Fly)

cell cycle regulator - a G1-S phase cyclin - nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Ets97D and Cyclin D/Cdk4

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CycD for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KUZ5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CycD-RD

FBtr0300391

NM_078631

2145

477

CycD-RE

FBtr0300392

NM_167472

2256

477

CycD-RF

FBtr0300393

NM_167473

2453

477

Additional Transcript Data and Comments

Reported size (kB)

2.3, 2.1 (northern blot)

(Finley et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CycD-PD

FBpp0289620

53.9

477

6.36

FBpp0289621

53.9

477

6.36

FBpp0289622

53.9

477

6.36

Q7KUZ5

NP_727913

AAF48537

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

477 aa isoforms: CycD-PD, CycD-PE, CycD-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

452 (aa)

(Finley et al., 1996)

Comments

A consensus seuquence for D cyclins was derived

from a comparison of the CycD sequence with 11 vertebrate D cyclins.

CycD protein is functional as shown by its ability to complement a yeast

cyclin mutant.

(Finley et al., 1996)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CycD using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.50

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & larval stage

(Finley et al., 1996)

embryonic stage 17

organism

(Finley et al., 1996)

third instar larval stage

eye-antennal disc

(Finley et al., 1996)

imaginal disc

(Finley et al., 1996)

eye disc morphogenetic furrow | anterior

(Finley et al., 1996)

adult stage | female

(Finley et al., 1996)

adult stage | male

(Finley et al., 1996)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CycD in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CycD

View exonic expression by tissue for Dmel\CycD

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010315

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32551/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010315

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010315

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010315

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9096

Flygut - An atlas of the Drosophila adult midgut

FBgn0010315

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CycD

Transgenic constructs containing regulatory region of CycD

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CycD^GD14114

viable, with Scer\GAL4^Mef2.PR

CycD^GD14114

viable, with Scer\GAL4^pnr-MD237

CycD^GD14114

viable, with Scer\GAL4^tin.CΔ4

CycD^GD14114

Sterility

Allele

sterile | recessive

Other Phenotypes

Allele

abnormal cell cycle | adult stage | mated male, with Scer\GAL4^esg.PU

CycD^HMS00059

abnormal cell growth | adult stage | male, with Scer\GAL4^esg.PU

CycD^HMS00059

abnormal locomotor behavior | adult stage, with Scer\GAL4^Mef2.PR

CycD^GD14114

abnormal size

CycD¹

decreased body size

decreased body size | somatic clone

decreased cell number

decreased cell size, with Scer\GAL4^da.G32

CycD^UAS.cMa

increased body size, with Scer\GAL4^da.G32

CycD^UAS.cMa

increased cell number, with Scer\GAL4^da.G32

CycD^UAS.cMa

increased cell size

wild-type, with Scer\GAL4^Act5C.PP

CycD^UAS.cDa

Phenotype manifest in

Allele

embryonic/larval midgut primordium

male accessory gland secondary cell, with Scer\GAL4^esg.PU

CycD^HMS00059

wing

wing, with Scer\GAL4^da.G32

CycD^UAS.cMa

wing | somatic clone

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\CCND2

12 of 14

Yes

Hsap\CCND3

11 of 14

Yes

Hsap\CCND1

10 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (16)

Rnor\Ccnd2

11 of 14

Yes

Rnor\Ccnd3

11 of 14

Yes

Rnor\Ccnd1

10 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (17)

Mmus\Ccnd2

12 of 14

Yes

Mmus\Ccnd3

11 of 14

Yes

Mmus\Ccnd1

10 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (32)

Xtro\ccndx

7 of 13

Yes

Xtro\ccnd1

6 of 13

Yes

Xtro\tigar

5 of 13

Yes

Xtro\anapc7

1 of 13

Xtro\anxa1.2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ccni

1 of 13

Xtro\elk3

1 of 13

Yes

Xtro\frem1l

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101730848

1 of 13

Xtro\LOC101732022

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (21)

Drer\ccnd2a

12 of 14

Yes

Drer\ccnd2b

10 of 14

Yes

Drer\ccnd1

9 of 14

Yes

Drer\ccnd3

7 of 14

Yes

Drer\ccndx

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\cyd-1

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP012299

8 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (33)

Atha\CYCD1;1

3 of 13

Yes

Atha\CYCD2;1

3 of 13

Yes

Atha\CYCD3;1

3 of 13

Yes

Atha\CYCD3;2

3 of 13

Yes

Atha\CYCD3;3

3 of 13

Yes

Atha\CYCD4;1

3 of 13

Yes

Atha\CYCD4;2

3 of 13

Yes

Atha\CYCD5;1

3 of 13

Yes

Atha\CYCD6;1

3 of 13

Yes

Atha\CYCD7;1

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (9)

Scer\CLB1

3 of 13

Yes

Scer\CLB2

3 of 13

Yes

Scer\CLB5

3 of 13

Yes

Scer\CLB6

3 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\cdc13

2 of 12

Yes

Spom\cig2

2 of 12

Yes

Spom\puc1

2 of 12

Yes

Spom\cig1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CycD. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

CycD^UAS.cUa

model of prostate cancer

CEA with Cdk4^UAS.cMa

(Sekar et al., 2023)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

CCND1; cyclin D1

model of multiple myeloma

IEA

(FlyBase, 2019-)

model of von Hippel-Lindau disease

IEA

(FlyBase, 2019-)

model of colorectal cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

CycD^UAS.cDa

ameliorates tuberous sclerosis

modeled by Tsc1^UAS.cTa, gig^UAS.cTa

(Tapon et al., 2001)

CycD^RNAi.UAS.cUa

ameliorates atypical teratoid rhabdoid tumor

modeled by Snr1^RNAi.UAS.cUa

(Jeibmann et al., 2014)

CycD^KK108447

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CCND2; cyclin D2

12 of 14

123833

MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 3; MPPH3

11 of 14

10 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

CycD

Mmus\Ccnd1

(Datar et al., 2006)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CycD - Cdk1

two hybrid

(Finley et al., 1996, Sauer et al., 1996)

CycD - Cdk2

two hybrid

(Finley et al., 1996, Sauer et al., 1996)

CycD - Cdk4

two hybrid

(Sauer et al., 1996)

CycD - Stat92E

anti bait coimmunoprecipitation, anti tag western blot

(Chen et al., 2003)

CycD - gig

anti tag coimmunoprecipitation, western blot

(Romero-Pozuelo et al., 2017)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cdk4|CycD

suppressible

Dad

(Sekar et al., 2023)

CycD|Cdk4

suppressible

Ets97D

(Baltzer et al., 2009)

CycD|Cdk4

suppressible

Hph

(Frei and Edgar, 2004)

CycD|Cdk4

suppressible

mRpL12

(Frei et al., 2005)

CycD|Cdk4

suppressible

Rbf

(Xin et al., 2002)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

E2f1

suppressible

CycD|Cdk4

(Ji et al., 2012)

suppressible

CycD|Cdk4

(Hipfner et al., 2002)

hkb

suppressible

CycD

(Matthew et al., 2024)

ptc

suppressible

CycD|Cdk4

(Duman-Scheel et al., 2002)

Rbf

suppressible

CycD|Cdk4

(Datar et al., 2000)

Rbf

suppressible

CycD

(Datar et al., 2006, Xin et al., 2002, Datar et al., 2000)

Snr1

suppressible

CycD

(Tegeder et al., 2019, Jeibmann et al., 2014)

Tsc1|gig

suppressible

CycD|Cdk4

(Tapon et al., 2001)

Tsc1|gig

suppressible

CycD

(Tapon et al., 2001)

upd1

enhanceable

CycD|Cdk4

(Chen et al., 2003)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58898

DroID - A comprehensive database of gene and protein interactions.

FBgn0010315

MIST (genetic) - An integrated Molecular Interaction Database

32551

MIST (protein-protein) - An integrated Molecular Interaction Database

32551

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q24158

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-52

Cytogenetic map

13F18-14A1

Sequence location

X:15,906,822..15,909,676 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

13F18-14A1

Limits computationally determined from genome sequence between P{EP}Gβ13F^EP1071 and P{EP}EP1458&P{EP}EP1522

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

13F-13F

(Jacobs, 2000.4.25)

Experimentally Determined Recombination Data

Location

1-52

(FlyBase, 2016)

1-52.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27718

y¹ v¹; P{TRiP.JF02799}attP2

55125

w¹ CycD¹/FM7c, P{ftz-lacC}YH1, sn⁺

83501

y¹ sc^* v¹ sev²¹; P{TKO.GS04221}attP40

33653

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00059}attP2

83588

y¹ sc^* v¹ sev²¹; P{SAM.dCas9.GS05224}attP40

FlyORF

F001624

M{UAS-CycD.ORF}ZH-86Fb

F001220

M{UAS-CycD.ORF.3xHA}ZH-86Fb

Kyoto

103741

y^* w^* P{GawB}CycD^NP0748 / FM7c

NIG-Fly

HMS00059

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00059}attP2

VDRC

v105361

P{KK108447}VIE-260B

v29024

w¹¹¹⁸; P{GD14114}v29024

v342063

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01484}attP40/CyO-GFP

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (174)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD22957

Other clones

DPiM_LD22957

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010315

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010315

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

CycD is not required for progression through the G₁ phase of the cell cycle.

(Emmerich et al., 2004)

The apparently indistinguishable phenotypes of CycD Cdk4 double mutants and either CycD or Cdk4 single mutant argue against major independent functions of CycD and Cdk4 in D.melanogaster.

(Emmerich et al., 2004)

CycD-Cdk4 is not a master regulator of the cell embryonic cell proliferation program.

(Meyer et al., 2002)

The primary function of CycD-Cdk4 is to stimulate growth.

(Datar et al., 2000)

Isolated by interaction with cdc2 and cdc2c using the interaction trap two hybrid system.

(Finley et al., 1996)

Yeast two-hybrid system has been used to characterise Cyclin-dependent kinase interactor proteins (the prey) in hunts with either cdc2 or cdc2c as baits. CycD interacts with cdc2, cdc2c and Cdi11, and other human and S.cerevisiae cyclin-dependent kinases to activate transcription of a reporter gene, Ecol\lacZ.

(Finley and Brent, 1994)

The yeast interaction trap selection has been used to isolate cell cycle regulatory proteins that interact with cdc2 and cdc2c. CycD interacts with cdc2 and cdc2c.

(Finley and Brent, 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: CycD CG9096

(Gong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CCND

(Lee et al., 2024)

CDI3

(Finley and Brent, 1993)

CG9096

(Kumar et al., 2016, Lin et al., 2015, Jeibmann et al., 2014, Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Brandt, 2006)

CYCD

(Arbouzova and Zeidler, 2006)

Cdi3

(Zhong et al., 2003, Finley et al., 1996)

Cyc D

(Yin et al., 2013)

Cyc-D

(Yadav et al., 2016)

CycD

(Fogarty et al., 2024, Matthew et al., 2024, Trujillo et al., 2024, Akhmanova et al., 2022, Bilder et al., 2021, Chaouch and Lasko, 2021, Strassburger et al., 2021, Arora and Ligoxygakis, 2020, Cho et al., 2020, Berlandi et al., 2019, Fahey-Lozano et al., 2019, Tegeder et al., 2019, Toshniwal et al., 2019, Won et al., 2019, Das et al., 2018, Eusebio et al., 2018, Hao et al., 2018, Muñoz-Soriano et al., 2018, Romero-Pozuelo et al., 2017, Transgenic RNAi Project members, 2017-, Doggett et al., 2015, Icreverzi et al., 2015, Panneton et al., 2015, Sanchez-Alvarez et al., 2015, Jeibmann et al., 2014, Merlo et al., 2014, Zhang et al., 2014, Das et al., 2013, Parisi et al., 2013, Schertel et al., 2013, Zhou and Luo, 2013, Zoranovic et al., 2013, Nawaz et al., 2012, Debat et al., 2011, Lindquist et al., 2011, Read, 2011, Toku et al., 2011, Beam and Moberg, 2010, Malzer et al., 2010, Maqbool et al., 2010, Nedelsky et al., 2010, Reddy et al., 2010, Dworkin et al., 2009, Hamaratoglu et al., 2009, Gupta et al., 2008, Berry and Baehrecke, 2007, Buszczak et al., 2007, Buttitta et al., 2007, Hueber et al., 2007, Kugler and Nagel, 2007, Brandt, 2006, Friedman and Perrimon, 2006, Gilboa and Lehmann, 2006, Jones et al., 2006, Khurana et al., 2006, Mukherjee et al., 2006, Nolo et al., 2006, Vrailas and Moses, 2006, Baonza and Freeman, 2005, Greene et al., 2005, Stanyon et al., 2004, Pickeral et al., 2000)

DmcycD

(Zraly et al., 2004)

cdi3

cycD

(Baillon et al., 2018, Taylor et al., 2017, Zhai et al., 2012, Pinto et al., 2011, Flannery et al., 2010, Genevet et al., 2009, Smith-Bolton et al., 2009, Bergman et al., 2007, Datar et al., 2006, Hyun et al., 2006, Tsai and Sun, 2004, Hipfner et al., 2002, Dong et al., 1997)

cyclin D

(Vinayagam et al., 2013)

cyclinD

(Gilbert et al., 2009, Gilbert et al., 2009, Li and White, 2003)

dCycD

(Ji et al., 2012, Delanoue et al., 2010, Read et al., 2009)

Name Synonyms

Cyclin-dependent kinase interactor 3

CyclinD

(Levayer and Moreno, 2013, Reddy et al., 2010, Baltzer et al., 2007, Mukherjee et al., 2006)

cyclin D

(Gupta et al., 2022, Noatynska et al., 2013, Vinayagam et al., 2013, Genevet et al., 2009, Tseng et al., 2007, Ren et al., 2004, Roy and Ingham, 2002, Foley and Sprenger, 2000)

cyclinD

(Layalle et al., 2008, Sasai et al., 2007)

dCyclinD

(Read et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 61 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32551

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KUZ5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KUZ5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010315

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32551/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010315

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010315

FlyMine - An integrated database for Drosophila genomics

FBgn0010315

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9096

MARRVEL_MODEL - MARRVEL (model organism gene)

32551

Linkouts

BioGRID - A database of protein and genetic interactions.

58898

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010315

DroID - A comprehensive database of gene and protein interactions.

FBgn0010315

DRSC - Results frm RNAi screens

FBgn0010315

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010315

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010315

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9096

Flygut - An atlas of the Drosophila adult midgut

FBgn0010315

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010315

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

32551

MIST (protein-protein) - An integrated Molecular Interaction Database

32551

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q24158

References (230)

The following external sites may use different assemblies or annotations than FlyBase.

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