FlyBase Allele Report: Dmel\CycD[1]

General Information

Symbol

Dmel\CycD¹

Species

D. melanogaster

Name

FlyBase ID

FBal0176298

Feature type

allele

Associated gene

Dmel\CycD

Associated Insertion(s)

P{?SUPor-P}CycD¹

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Emmerich et al., 2004)

Progenitor genotype

P{SUPor-P}KG04817

(Emmerich et al., 2004)

Associated Insertion(s)

P{?SUPor-P}CycD¹

Cytology

Description

Imprecise excision of the P{SUPor-P}KG04817 element, resulting in a deletion extending from 1011bp upstream of the start of the CycD coding region to 892bp downstream of the start of the CycD coding region. 29bp of residual P-element sequences remain.

(Emmerich et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size

(Datar et al., 2006)

decreased body size

(Emmerich et al., 2004)

decreased body size | somatic clone

(Emmerich et al., 2004)

decreased cell number

(Emmerich et al., 2004)

increased cell size

(Emmerich et al., 2004)

sterile | recessive

(Emmerich et al., 2004)

viable

(Emmerich et al., 2004)

Phenotype Manifest In

embryonic/larval midgut primordium

(Emmerich et al., 2004)

wing

(Datar et al., 2006, Emmerich et al., 2004)

wing | somatic clone

(Emmerich et al., 2004)

Detailed Description

Statement

Reference

Mutant flies show a reduction in body weight and show a reduction in wing size compared to wild type-controls.

(Datar et al., 2006)

The fertility of homozygous females and hemizygous males is severely reduced, although a few adult progeny can be obtained from mutant parents. Hemizygous adult males weigh on average only 85% of the weight of control males. The average wing area of hemizygous males is only 88% that of wild type and the number of cells in the wing is 85% that of wild type. The cells in the wing of hemizygous males are slightly increased compared to wild type. Homozygous clones in the wing induced approximately 60 hours after egg laying and allowed to develop for a further 60 hours cover only about 50% of the area of the control sister clones. There is no increase in the number of apoptotic cells associated with the mutant clones, and the mutant cells show no significant differences in cell size or cell-cycle phasing compared to control cells. Endoreduplication is not initiated on time in the central domain of the midgut in mutant embryos, and is inefficient and not completed on time within the anterior and posterior midgut domains.

(Emmerich et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

CycD¹ has abnormal size phenotype, suppressible | partially by Scer\GAL4^da.PU/Mmus\Ccnd1^UAS.cDa

(Datar et al., 2006)

Suppressor of

Statement

Reference

CycD¹ is a suppressor of increased occurrence of cell division | embryonic stage phenotype of hkb³⁵¹

(Matthew et al., 2024)

Other

Statement

Reference

CycB², CycD¹ has viable phenotype

(Emmerich et al., 2004)

CycB3³, CycD¹ has viable phenotype

(Emmerich et al., 2004)

CycD¹, CycE^AR95 has partially lethal | dominant phenotype

(Emmerich et al., 2004)

CycD¹, CycE[+]/CycE⁰⁵²⁰⁶ has lethal phenotype

(Emmerich et al., 2004)

Cdk2²/cdc2c[+], CycD¹ has lethal phenotype

(Emmerich et al., 2004)

Cdk2³/cdc2c[+], CycD¹ has lethal phenotype

(Emmerich et al., 2004)

CycD¹, CycE⁰⁵²⁰⁶ has lethal | dominant phenotype

(Emmerich et al., 2004)

CycD¹, Dp^a2 has partially lethal | dominant phenotype

(Emmerich et al., 2004)

CycD¹, Dp^a4 has partially lethal | dominant phenotype

(Emmerich et al., 2004)

CycD¹, E2f1⁹¹ has viable phenotype

(Emmerich et al., 2004)

Cdk1^B47, CycD¹ has viable phenotype

(Emmerich et al., 2004)

Cdk1^E1-23, CycD¹ has viable phenotype

(Emmerich et al., 2004)

CycA^C8LR1/CycA[+], CycD¹ has partially lethal phenotype

(Emmerich et al., 2004)

Cdk2², CycD¹ has lethal | dominant phenotype

(Emmerich et al., 2004)

Cdk2³, CycD¹ has lethal | dominant phenotype

(Emmerich et al., 2004)

CycD¹, dap⁴ has viable phenotype

(Emmerich et al., 2004)

CycD¹, dap^G36 has viable phenotype

(Emmerich et al., 2004)

CycB3³/CycB3[+], CycD¹ has viable phenotype

(Emmerich et al., 2004)

CycB[+]/CycB², CycD¹ has viable phenotype

(Emmerich et al., 2004)

CycD¹, E2f[+]/E2f1⁹¹ has viable phenotype

(Emmerich et al., 2004)

cdc2[+]/Cdk1^B47, CycD¹ has viable phenotype

(Emmerich et al., 2004)

CycD¹, dap[+]/dap⁴ has viable phenotype

(Emmerich et al., 2004)

CycD¹, dap^G36/dap[+] has viable phenotype

(Emmerich et al., 2004)

cdc2[+]/Cdk1^E1-23, CycD¹ has viable phenotype

(Emmerich et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

CycD¹ has wing phenotype, suppressible | partially by Scer\GAL4^da.PU/Mmus\Ccnd1^UAS.cDa

(Datar et al., 2006)

Suppressor of

Statement

Reference

CycD¹ is a suppressor of embryonic/larval salivary gland | embryonic stage phenotype of hkb³⁵¹

(Matthew et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Adult viability of CycD¹/Y ; cdc2c²/+ males is only 6% of expected value. Adult viability of CycD¹/Y ; cdc2c³/+ males is 0%. Adult viability of CycD¹/Y ; CycE^AR95/+ males is only 35% of expected value. Adult viability of CycD¹/Y ; CycE⁰⁵²⁰⁶/+ males is only 61% of expected value. Adult viability of CycD¹/Y ; CycA^C8LR1/+ males is 89% of expected value. Adult viability of CycD¹/Y ; Dp^a2/+ males is 64% of expected value. Adult viability of CycD¹/Y ; Dp^a4/+ males is 67% of expected value.

(Emmerich et al., 2004)

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\Ccnd1^Scer\UAS.cDa under the control of Scer\GAL4^da.G32 partially suppresses the reduced body weight and reduced wing size of CycD¹ flies.

(Datar et al., 2006)

Complementation and Rescue Data

Rescued by

CycD¹ is rescued by CycD^UAS.cMa/Scer\GAL4^da.G32

(Emmerich et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

55125

w¹ CycD¹/FM7c, P{ftz-lacC}YH1, sn⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CycD¹

(Matthew et al., 2024, Baumgardt et al., 2014, Kugler and Nagel, 2007)

cycd¹

(Datar et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close