CycE05206 in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces no viable flies.
No BrdU incorporation is detected in the anterior midgut cells of stage 13 CycE05206/CycE2 embryos. However, at stage 14 some BrdU incorporation is detected in these cells. This suggests the G1-S transition is delayed. 3.7% of CycE05206/CycE2 animals eclose. These flies are sterile, have rough eyes and the fifth wing vein is incompletely formed.
Flies transheterozygous for CycE05206 and CycEk02514 are viable but have rough eyes and wing venation defects.
DNA replication is not detected in the endodomains of homozygous embryos.