FlyBase Allele Report: Dmel\CycB3[3]

General Information

Symbol

Dmel\CycB3³

Species

D. melanogaster

Name

FlyBase ID

FBal0094858

Feature type

allele

Associated gene

Dmel\CycB3

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Jacobs et al., 1998)

Mutagen

Delta2-3 transposase

(Jacobs et al., 1998)

Progenitor genotype

CycB3^L6540

(Jacobs et al., 1998)

Cytology

Description

Deletion from 5' UTR, including the region encoding α-helix 1, a conserved element of the cyclin box essential for cdc2 binding.

(Jacobs et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Jacobs et al., 1998)

viable

(Jacobs et al., 1998)

Phenotype Manifest In

meiosis I

(Jacobs et al., 1998)

Detailed Description

Statement

Reference

Oogenesis proceeds normally until after entry into meiosis I, exit from meiosis after egg activation is defective. Homozygotes and hemizygotes reach adulthood.

(Jacobs et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CycB3³, CycD¹ has viable phenotype

(Emmerich et al., 2004)

CycB3³/CycB3[+], CycD¹ has viable phenotype

(Emmerich et al., 2004)

CycB3³, CycB² has lethal phenotype

(Jacobs et al., 1998)

CycB3³, CycB³ has lethal phenotype

(Jacobs et al., 1998)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

CycB3³/CycB3[+] is a non-enhancer of mitotic domain 1 | embryonic cycle 14 phenotype of CycB^+t10

(Ji et al., 2002)

NOT Suppressor of

Statement

Reference

CycB3³/CycB3[+] is a non-suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB^+t10

(Ji et al., 2002)

Other

Statement

Reference

CycB3³, CycB² has embryo | embryonic cycle 15 phenotype

(Jacobs et al., 1998)

CycB3³, Df(2R)599-5 has embryo | embryonic cycle 15 phenotype

(Jacobs et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

CycB3³ CycB (CycB² or Df(2R)599-5) double mutants have defective late mitotic figures during mitosis 15 at stage 10 and multipolar spindles at stage 13.

(Jacobs et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

CycB3³ is rescued by CycB3^+t9

(Jacobs et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CycB3³

(Althoff et al., 2009)

cycB3³

(Ji et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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