FlyBase Allele Report: Dmel\CycB[+t10]

General Information

Symbol

Dmel\CycB^+t10

Species

D. melanogaster

Name

FlyBase ID

FBal0094857

Feature type

allele

Associated gene

Dmel\CycB

Associated Insertion(s)

Carried in Construct

P{CycB⁺.J}

Also Known As

P[w⁺ cycB⁺]

Key Links

Transgenic product class

genomic_DNA

(Jacobs et al., 1998)

wild_type

(Jacobs et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Jacobs et al., 1998)

wild_type

(Jacobs et al., 1998)

Mutagen

in vitro construct

(Jacobs et al., 1998)

Progenitor genotype

Carried in construct

P{CycB⁺.J}

Cytology

Description

10kb genomic fragment of CycB inserted in P{CaSpeR-4}.

(Jacobs et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

CycB

Encoded product / tool

CycB

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

anaphase & condensed nuclear chromosome | maternal effect

(Ji et al., 2004)

aster | embryonic cycle 5

(Ji et al., 2002)

aster | embryonic cycle 6

(Ji et al., 2002)

aster | embryonic cycle 7

(Ji et al., 2002)

astral microtubule | embryonic cycle 9 | maternal effect

(Ji et al., 2005)

embryo | embryonic cycle 6 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 7 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 8 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 9 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 10 | maternal effect

(Ji et al., 2005, Ji et al., 2004)

embryo | embryonic cycle 11 | maternal effect

(Ji et al., 2004)

embryo | embryonic cycle 14 | maternal effect

(Ji et al., 2005)

energid

(Ji et al., 2002)

microtubule | embryonic cycle 9 | maternal effect

(Ji et al., 2005)

mitotic domain 1 | embryonic cycle 10

(Crest et al., 2007, Ji et al., 2002)

mitotic domain 1 | embryonic cycle 12

(Crest et al., 2007)

mitotic domain 1 | embryonic cycle 14

(Crest et al., 2007, Ji et al., 2002)

mitotic interphase | embryonic cycle 10

(Crest et al., 2007)

mitotic interphase | embryonic cycle 11

(Crest et al., 2007)

mitotic interphase | embryonic cycle 12

(Crest et al., 2007)

mitotic interphase | embryonic cycle 13

(Crest et al., 2007)

mitotic interphase | maternal effect

(Ji et al., 2004)

mitotic metaphase | maternal effect

(Ji et al., 2004)

mitotic prophase | maternal effect

(Ji et al., 2004)

Detailed Description

Statement

Reference

Embryos derived from females carrying four copies of CycB^+t10 (as well as two wild-type copies of CycB⁺) show multiple nonlethal phenotypes, one of which is a delay in arrival of the nuclei to the cortex. 91% of these embryos have normal nuclear morphology at cycle 10, while in later blastoderm cycles the frequency of these embryos with normal nuclear morphology drops to 76% and is lowest at cycle 12. The abnormal embryos show one or more of the following mutant phenotypes; patches of extra mitoses, areas of the blastoderm devoid of nuclei, chromosomal bridges and/or macro- or micro-nuclei. M-phase is seen at cycle 14 in these embryos. More than 90% of these embryos hatch and develop to adulthood.

Embryos derived from females carrying four copies of CycB^+t10 (as well as two wild-type copies of CycB⁺) have a shorter interphase duration than normal and a longer prophase-metaphase duration than normal in cycles 10, 11, 12 and 13, while the anaphase-telophase duration is normal during these cycles.

(Crest et al., 2007)

Embryos with two extra copies of the maternal CycB⁺ gene dose (derived from females carrying copies of CycB^+t10) show a delay in the onset of anaphase (measured during cycles 6-11) compared to wild type. Nuclear cortical migration is initiated at telophase of cycle 9 and ends about 1.5 minutes into early interphase of cycle 10, as occurs in wild-type embryos, but the velocity and pattern of nuclear migration is abnormal; nuclei move move slowly than normal and they move to the cortex like "drunken soldiers" - moving in meandering lines towards the cortex (the nuclei migrate in straight paths perpendicular to the cortex in wild-type embryos). Embryos with four extra copies of the maternal CycB⁺ gene dose (derived from females carrying copies of CycB^+t10) have an abnormal nuclear distribution at cycle 10, with nuclei at the anterior-medial region failing to reach the cortex simultaneously in more than 80% of embryos. Embryos with four extra copies of the maternal CycB⁺ gene dose (derived from females carrying copies of CycB^+t10) have a slightly lower hatching rate and a higher frequency of abnormal nuclear distribution and morphology at cycle 14 interphase. Embryos with four extra copies of the maternal CycB⁺ gene dose (derived from females carrying copies of CycB^+t10) have a reduced microtubule network (measured during early interphase of cycle 9). These embryos have a significantly higher fraction of metaphase spindles with no visible astral microtubules at cycle 9 than wild-type embryos.

(Ji et al., 2005)

Embryos carrying the CycB^+t10 transgene show mitotic defects such as loss of cell synchrony but do not contain interacting spindles or multipolar spindles. During mitosis of cycle 12, CycB^+t10 embryos show normal localization of nuclei and centrosomes.

(Stumpff et al., 2005)

The velocity of sister chromatid separation in anaphase of mitotic cycles 6-8 increases significantly with increasing maternal CycB gene dosage: CycB^unspecified/+ < wild-type < 2XCycB^+t10. This is reflected in a decrease in anaphase duration. The duration of prophase + metaphase between cycles 6 and 10 increases with increasing maternal CycB gene dosage (genetics as above), but the length of interphase during these cycles decreases with increasing maternal CycB gene dosage (CycB^unspecified/+ > wild-type > 2XCycB^+t10. This latter effect is particularly pronounced in later mitotic cycles (10 and 11).

(Ji et al., 2004)

Embryos derived from females carrying six copies of CycB (4 copies of CycB^+t10 in a wild-type background) show defects at nuclear cycle 10; nuclei reach the periphery of the embryo later and nonsynchronously and it takes more than one cycle for a uniform distribution of nuclei at the cortex to form. 26% of these embryos have patches of mitotic nuclei during cycle 14 interphase and areas of lower nuclear density. Chromosomal bridges and macro- and micronuclei are occasionally seen. These embryos have only a slightly reduced hatching rate (92% compared to 96% in controls). Only 60% of cycle 5-7 embryos have metaphase spindles with asters, compared to 84% in wild-type controls. Energids in these embryos migrate at a rate of 8.9μm/min, which is slower than in wild type. The embryos have one more axial expansion cycle than normal and nuclei move slightly but for a significantly longer time. It takes longer and more than one cycle for all somatic buds to appear at the surface of the embryo.

(Ji et al., 2002)

CycB^+t10 does not result in the onset of mitosis in wild-type nurse cells.

(Kashevsky et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

CycB^+t10 has abnormal mitotic cell cycle | embryonic stage | maternal effect phenotype, enhanceable by thr[+]/thr¹

(Ji et al., 2005)

Suppressed by

Statement

Reference

CycB^+t10 has abnormal mitotic cell cycle | maternal effect | embryonic stage phenotype, suppressible by pim^IL/pim[+]

(Ji et al., 2005)

CycB^+t10 has abnormal mitotic cell cycle | maternal effect | embryonic stage phenotype, suppressible by Sse^13m/Sse[+]

(Ji et al., 2005)

Enhancer of

Statement

Reference

CycB^+t10 is an enhancer of partially lethal phenotype of mr¹/mr³

(Kashevsky et al., 2002)

Suppressor of

Statement

Reference

CycB^+t10 is a suppressor of abnormal mitotic cell cycle | maternal effect phenotype of png³³¹⁸

(Lee et al., 2001)

CycB^+t10 is a suppressor of abnormal mitotic cell cycle | maternal effect phenotype of png¹⁰⁵⁸

(Lee et al., 2001)

Other

Statement

Reference

CycB^+t10, Df(1)N19/+ has partially lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2L)DS6/+ has partially lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(3L)fz-GF3b/+ has lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(3L)fz-M21/+ has lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2L)pr-A14/+ has lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2L)TW2/+ has lethal phenotype

(Crest et al., 2007)

CycB^+t10, +/Df(2L)TW65 has lethal phenotype

(Crest et al., 2007)

CycB^+t10, +/Df(2L)Exel7078 has lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2L)ED1317/+ has partially lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2L)TW1/+ has lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2L)TW161/+ has lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2L)TW84/+ has lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2R)AA21/+ has partially lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2R)PC4/+ has partially lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2R)Pcl11B/+ has lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(2R)Pcl7B/+ has partially lethal phenotype

(Crest et al., 2007)

CycB^+t10, Df(3L)Ar14-8/+ has partially lethal phenotype

(Crest et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by Df(2R)PC4/+

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by Df(2R)Pcl11B/+

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by Df(2R)Pcl7B/+

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr[+]/thr^13C4

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr[+]/thr^13C4

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr[+]/thr¹

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr[+]/thr¹

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr[+]/thr³

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr[+]/thr³

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr[+]/thr^3E22

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr[+]/thr^3E22

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr[+]/thr^5E16

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr[+]/thr^5E16

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr^BH9/thr[+]

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr^BH9/thr[+]

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr[+]/thr^IL62

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr[+]/thr^IL62

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr[+]/thr^P9.8

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr[+]/thr^P9.8

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr[+]/thr^SJB22

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr[+]/thr^SJB22

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 10 | maternal effect phenotype, enhanceable by thr[+]/thr^k07805b

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, enhanceable by thr[+]/thr^k07805b

(Ji et al., 2005)

CycB^+t10 has astral microtubule | embryonic cycle 9 | maternal effect phenotype, enhanceable by Df(3L)SseA/+

(Ji et al., 2005)

CycB^+t10 has astral microtubule | embryonic cycle 9 | maternal effect phenotype, enhanceable by Sse^13m/Sse[+]

(Ji et al., 2005)

CycB^+t10 has aster | embryonic cycle 5 phenotype, enhanceable by Dhc64C[+]/Dhc64C^4-19

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, enhanceable by Dhc64C[+]/Dhc64C^4-19

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(1)N19/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(2L)DS6/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(2L)Gpdh1-A/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(2L)TW1/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(2L)TW161/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(2L)TW84/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(2R)AA21/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(2R)PC4/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(2R)Pcl11B/+

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, enhanceable by Dhc64C[+]/Dhc64C^4-19

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(2R)Pcl7B/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(3L)Ar14-8/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(3L)fz-GF3b/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, enhanceable by Df(3L)fz-M21/+

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, enhanceable by Dhc64C[+]/Dhc64C^6-10

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, enhanceable by Dhc64C[+]/Dhc64C^6-10

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, enhanceable by Dhc64C[+]/Dhc64C^6-10

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, enhanceable by robl^K/robl[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, enhanceable by robl^K/robl[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, enhanceable by robl^K/robl[+]

(Ji et al., 2002)

CycB^+t10 has energid phenotype, enhanceable by dia²/dia[+]

(Ji et al., 2002)

NOT Enhanced by

Statement

Reference

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, non-enhanceable by Df(2R)Pcl-W5/+

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, non-enhanceable by Df(3L)GN24/+

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, non-enhanceable by Df(3L)GN50/+

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, non-enhanceable by Df(3L)ZN47/+

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, non-enhanceable by eay[+]/eay^unspecified

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, non-enhanceable by hal[+]/Ote^unspecified

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, non-enhanceable by stau^unspecified/stau[+]

(Ji et al., 2005)

CycB^+t10 has embryo | embryonic cycle 14 | maternal effect phenotype, non-enhanceable by sub[+]/sub^unspecified

(Ji et al., 2005)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by α-Spec^rg41/alpha-Spec[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by beta-Spec[+]/β-Spec^emb

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by Cdc42[+]/Cdc42⁴

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by CycB3²/CycB3[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by CycB3³/CycB3[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by Rca1¹¹²⁹⁴/Rca1[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by capu[+]/capu¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by grp[+]/grp⁰⁶⁰³⁴

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by kst[+]/kst^unspecified

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by pnut[+]/pnut⁰²⁵⁰²

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by pnut[+]/pnut^XP

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by scra[+]/scra⁸

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by stg[+]/stg¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by wee[+]/Wee1^DS1

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-enhanceable by Wee1^ES1/wee[+]

(Ji et al., 2002)

Suppressed by

Statement

Reference

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by RPA2³/RPA2[+]

(Crest et al., 2007)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by RPA2²/RPA2[+]

(Crest et al., 2007)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by RPA2^KG00759/CG9273[+]

(Crest et al., 2007)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by +/Df(2L)Exel7080

(Crest et al., 2007)

CycB^+t10 has mitotic interphase | embryonic cycle 12 phenotype, suppressible by RPA2²/RPA2[+]

(Crest et al., 2007)

CycB^+t10 has mitotic interphase | embryonic cycle 13 phenotype, suppressible by RPA2²/RPA2[+]

(Crest et al., 2007)

CycB^+t10 has embryo | maternal effect | embryonic cycle 10 phenotype, suppressible by Df(3L)SseA/+

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 10 phenotype, suppressible by Sse^13m/Sse[+]

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 10 phenotype, suppressible by pim³/pim[+]

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 10 phenotype, suppressible by pim⁴/pim[+]

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 10 phenotype, suppressible by pim^IL/pim[+]

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, suppressible by Df(2L)J77/+

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, suppressible by Df(3L)SseA/+

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, suppressible by Sse^13m/Sse[+]

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, suppressible by pim³/pim[+]

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, suppressible by pim⁴/pim[+]

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, suppressible by pim^IL/pim[+]

(Ji et al., 2005)

CycB^+t10 has microtubule | maternal effect | embryonic cycle 9 phenotype, suppressible by Sse^13m/Sse[+]

(Ji et al., 2005)

CycB^+t10 has microtubule | maternal effect | embryonic cycle 9 phenotype, suppressible by pim^IL/pim[+]

(Ji et al., 2005)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by CycA^C8LR1/CycA[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by Df(2L)J77/+

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by Df(3R)kar-Sz21/+

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by +/Df(3R)ry615

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by Gl[+]/DCTN1-p150^Gl-1

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by cdc2[+]/Cdk1^D57

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by chic[+]/chic⁰⁷⁸⁸⁶

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by chic[+]/chic¹³

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by chic[+]/chic¹⁵

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by qua[+]/qua¹⁰

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by qua[+]/qua^WP165

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by sced[+]/sced¹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by sqh¹/sqh[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by sqh²/sqh[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by chic[+]/chic¹⁰

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by chic[+]/chic¹⁴

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, suppressible by CycA^C8LR1/CycA[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, suppressible by chic[+]/chic⁰⁷⁸⁸⁶

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, suppressible by chic[+]/chic¹⁵

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, suppressible by qua[+]/qua^WP165

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, suppressible by sced[+]/sced¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, suppressible by dia²/dia[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Cdc42[+]/Cdc42²

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by CycA[+]/CycA⁵

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by CycA^C8LR1/CycA[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Df(1)Bar/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Df(2L)J77/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Df(2L)spd^j2/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Df(2R)cn9/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by +/Df(3L)R-G5

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Df(3L)fz-GS1a/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Df(3L)vin7/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Df(3R)crb87-4/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Df(3R)kar-Sz21/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by +/Df(3R)kar-Sz8

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by Df(3R)ry614/+

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by +/Df(3R)ry615

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by cdc2[+]/Cdk1^D57

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by chic[+]/chic⁰⁷⁸⁸⁶

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by chic[+]/chic¹³

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by chic[+]/chic¹⁴

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by chic[+]/chic¹⁵

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by dia[+]/dia¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by dia²/dia[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by dia[+]/dia⁹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by qua[+]/qua¹⁰

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by qua[+]/qua⁹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by sced[+]/sced¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by sqh¹/sqh[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, suppressible by zip[+]/zip¹

(Ji et al., 2002)

CycB^+t10 has energid phenotype, suppressible by chic[+]/chic⁰⁷⁸⁸⁶

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by Arp87C[+]/Arp1^unspecified

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by CycA[+]/CycA⁵

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by CycA^C8LR1/CycA[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by Df(2L)J77/+

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by Df(3R)kar-Sz21/+

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by +/Df(3R)ry615

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by Gl[+]/DCTN1-p150^Gl-1

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by cdc2[+]/Cdk1^D57

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by chic[+]/chic⁰⁷⁸⁸⁶

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by chic[+]/chic¹³

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by chic[+]/chic¹⁵

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by qua[+]/qua¹⁰

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by qua[+]/qua^WP165

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by sced[+]/sced¹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by sqh¹/sqh[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by sqh²/sqh[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by chic[+]/chic¹⁰

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, suppressible by chic[+]/chic¹⁴

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by Arp87C[+]/Arp1^unspecified

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by CycA[+]/CycA⁵

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by CycA^C8LR1/CycA[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by Df(2L)J77/+

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by Df(3R)kar-Sz21/+

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by +/Df(3R)ry615

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by Gl[+]/DCTN1-p150^Gl-1

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by cdc2[+]/Cdk1^D57

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by chic[+]/chic⁰⁷⁸⁸⁶

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by chic[+]/chic¹³

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by chic[+]/chic¹⁵

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by qua[+]/qua¹⁰

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by qua[+]/qua^WP165

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by sced[+]/sced¹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by sqh¹/sqh[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by sqh²/sqh[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by chic[+]/chic¹⁰

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, suppressible by chic[+]/chic¹⁴

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by Arp87C[+]/Arp1^unspecified

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, suppressible by CycA[+]/CycA⁵

(Ji et al., 2002)

NOT suppressed by

Statement

Reference

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, non-suppressible by RPA2³/RPA2[+]

(Crest et al., 2007)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, non-suppressible by RPA2²/RPA2[+]

(Crest et al., 2007)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, non-suppressible by RPA2^KG00759/CG9273[+]

(Crest et al., 2007)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, non-suppressible by +/Df(2L)Exel7080

(Crest et al., 2007)

CycB^+t10 has mitotic interphase | embryonic cycle 10 phenotype, non-suppressible by RPA2²/RPA2[+]

(Crest et al., 2007)

CycB^+t10 has mitotic interphase | embryonic cycle 11 phenotype, non-suppressible by RPA2²/RPA2[+]

(Crest et al., 2007)

CycB^+t10 has embryo | maternal effect | embryonic cycle 10 phenotype, non-suppressible by pim[+]/pim²

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, non-suppressible by Df(3L)GN24/+

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, non-suppressible by Df(3L)GN50/+

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, non-suppressible by Df(3L)ZN47/+

(Ji et al., 2005)

CycB^+t10 has embryo | maternal effect | embryonic cycle 14 phenotype, non-suppressible by pim[+]/pim²

(Ji et al., 2005)

CycB^+t10 has phenotype, non-suppressible by cdc2[+]/Cdk1^E1-24

(Ji et al., 2002)

CycB^+t10 has phenotype, non-suppressible by cdc2[+]/Cdk1^216P

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, non-suppressible by Cdc42[+]/Cdc42²

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, non-suppressible by Dmn[+]/DCTN2-p50^k16109

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, non-suppressible by chic[+]/chic²⁸¹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, non-suppressible by dia[+]/dia¹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, non-suppressible by dia²/dia[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, non-suppressible by dia[+]/dia⁹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, non-suppressible by qua[+]/qua⁹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 6 phenotype, non-suppressible by zip[+]/zip¹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, non-suppressible by Cdc42[+]/Cdc42²

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, non-suppressible by Dmn[+]/DCTN2-p50^k16109

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, non-suppressible by Cdc42[+]/Cdc42²

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, non-suppressible by chic[+]/chic²⁸¹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, non-suppressible by dia[+]/dia¹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, non-suppressible by dia²/dia[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, non-suppressible by dia[+]/dia⁹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, non-suppressible by qua[+]/qua⁹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 7 phenotype, non-suppressible by zip[+]/zip¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, non-suppressible by Cdc42[+]/Cdc42²

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 10 phenotype, non-suppressible by zip[+]/zip¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by α-Spec^rg41/alpha-Spec[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by beta-Spec[+]/β-Spec^emb

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, non-suppressible by Dmn[+]/DCTN2-p50^k16109

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by Arp87C[+]/Arp1^unspecified

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by Cdc42[+]/Cdc42⁴

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by CycB3²/CycB3[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by CycB3³/CycB3[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by Dmn[+]/DCTN2-p50^k16109

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by Rca1¹¹²⁹⁴/Rca1[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by capu[+]/capu¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by chic[+]/chic¹⁰

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by chic[+]/chic²⁸¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by grp[+]/grp⁰⁶⁰³⁴

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, non-suppressible by chic[+]/chic²⁸¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by kst[+]/kst^unspecified

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by pnut[+]/pnut⁰²⁵⁰²

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by pnut[+]/pnut^XP

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by qua[+]/qua^WP165

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by scra[+]/scra⁸

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by sqh²/sqh[+]

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by stg[+]/stg¹

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by wee[+]/Wee1^DS1

(Ji et al., 2002)

CycB^+t10 has mitotic domain 1 | embryonic cycle 14 phenotype, non-suppressible by Wee1^ES1/wee[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, non-suppressible by dia[+]/dia¹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, non-suppressible by dia²/dia[+]

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, non-suppressible by dia[+]/dia⁹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, non-suppressible by qua[+]/qua⁹

(Ji et al., 2002)

CycB^+t10 has aster | embryonic cycle 5 phenotype, non-suppressible by zip[+]/zip¹

(Ji et al., 2002)

Suppressor of

Statement

Reference

CycB^+t10 is a suppressor of phenotype of gnu³⁰⁵

(Lee et al., 2001)

CycB^+t10 is a suppressor of phenotype of plu⁶

(Lee et al., 2001)

NOT Suppressor of

Statement

Reference

CycB^+t10 is a non-suppressor of polar body nucleus phenotype of gnu³⁰⁵

(Lee et al., 2001)

CycB^+t10 is a non-suppressor of polar body nucleus phenotype of plu⁶

(Lee et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

93% of embryos derived from females carrying four copies of CycB^+t10 (as well as two wild-type copies of CycB⁺) and also heterozygous for RPA2³ have a normal phenotype at cycle 14, while only 31% of these embryos have a normal phenotype at cycle 10.

89% of embryos derived from females carrying four copies of CycB^+t10 (as well as two wild-type copies of CycB⁺) and also heterozygous for RPA2² have a normal phenotype at cycle 14, while only 23% of these embryos have a normal phenotype at cycle 10.

97% of embryos derived from females carrying four copies of CycB^+t10 (as well as two wild-type copies of CycB⁺) and also heterozygous for RPA2^KG00759 have a normal phenotype at cycle 14, while only 24% of these embryos have a normal phenotype at cycle 10.

93% of embryos derived from females carrying four copies of CycB^+t10 (as well as two wild-type copies of CycB⁺) and also heterozygous for Df(2L)Exel7080 have a normal phenotype at cycle 14, while only 25% of these embryos have a normal phenotype at cycle 10.

The shorter than normal interphase duration seen in embryos derived from females carrying four copies of CycB^+t10 (as well as two wild-type copies of CycB⁺) is not suppressed by RPA2²/+ at cycle 10 or 11, but is partially suppressed by RPA2²/+ at cycle 12 and is suppressed by RPA2²/+ to wild type duration at cycle 13.

(Crest et al., 2007)

The delay in onset of anaphase (measured during cycles 6-11) seen in embryos with two extra copies of the maternal CycB⁺ gene dose (derived from females carrying copies of CycB^+t10) is enhanced by thr¹ and is suppressed by pim^IL or Sse^13m. Nuclear cortical migration is initiated at telophase of cycle 9 and ends about 1.5 minutes into early interphase of cycle 10 in embryos with two extra copies of the maternal CycB⁺ gene dose (derived from females carrying copies of CycB^+t10) and carrying either pim^IL or Sse^13m, as occurs in wild-type embryos, but the velocity and pattern of nuclear migration are abnormal; nuclear movements are faster than in wild-type embryos and the nuclei move in curved paths and at an angle to the cortex (the nuclei migrate in straight paths perpendicular to the cortex in wild-type embryos). The reduction in the microtubule network (measured during early interphase of cycle 9) seen in embryos with four extra copies of the maternal CycB⁺ gene dose (derived from females carrying copies of CycB^+t10) is suppressed by pim^IL/+ or Sse^13m/+. The loss of astral microtubules seen in cycle 9 embryos with four extra copies of the maternal CycB⁺ gene dose is enhanced if they also carry Sse^13m/+ or Df(3L)SseA/+.

(Ji et al., 2005)

Embryos derived from png² homozygous females that are also carrying multiple copies of CycB^+t10 show a striking increase in the number of nuclei in each embryo compared to embryos derived from png² females, as well as an increase in the number of embryos with multiple nuclei. The polar bodies contain condensed chromosomes with a normal rosette arrangement. The chromosomes of the zygotic nuclei are condensed and mitotic figures are visible. However, all the embryos contain polyploid nuclei and none survive past embryogenesis. 39% of embryos derived from plu⁶ females carrying 4 copies of CycB^+t10 are multinucleated, compared to only 1.5% of those derived from plu⁶ single mutant females. The polar body defects are not corrected. 65% of embryos derived from gnu³⁰⁵ females carrying 4 copies of CycB^+t10 are multinucleated, compared to only 0.8% of those derived from gnu³⁰⁵ single mutant females. The polar body defects are not corrected.

(Lee et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

CycB^+t10 rescues CycB³

(Jacobs et al., 1998)

CycB^+t10 rescues CycB²

(Jacobs et al., 1998)

Comments

Rescues female and male sterility of null mutations. Rescues lethality of CycB3, CycB3 double mutants.

(Jacobs et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CycB^+t10

six cycB

(Stumpff et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (9)

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