FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pim4
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General Information
Symbol
Dmel\pim4
Species
D. melanogaster
Name
FlyBase ID
FBal0035397
Feature type
allele
Associated gene
Dmel\pim
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Stratmann and Lehner, 1996)
Mutagen
ethyl methanesulfonate
(Stratmann and Lehner, 1996)
Progenitor genotype
Cytology
Description

Nucleotide substitution: bases 619-627 replaced by ATCAAGA. Causes a frameshift after amino-acid 123 resulting in addition of 10 unrelated amino acids followed by a stop.

(Stratmann and Lehner, 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:10,363,595..10,363,603 [+]
Comment:

9 bases are replaced by ATCAAGA resulting in a frameshift after amino acid 123.

Inserted_sequence:

ATCAAGA

(Stratmann and Lehner, 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Chromosome distribution in mitosis is defective. Sister chromatid separation in the centromeric region fails.

      (Stratmann and Lehner, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      pim4/pim[+] is a suppressor of embryo | maternal effect | embryonic cycle 10 phenotype of CycB+t10

      (Ji et al., 2005)

      pim4/pim[+] is a suppressor of embryo | maternal effect | embryonic cycle 14 phenotype of CycB+t10

      (Ji et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pim4
      Name Synonyms
      Secondary FlyBase IDs
        References (2)