FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sqh2
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General Information
Symbol
Dmel\sqh2
Species
D. melanogaster
Name
FlyBase ID
FBal0050556
Feature type
allele
Associated gene
Dmel\sqh
Associated Insertion(s)
P{}sqh2
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Edwards and Kiehart, 1996)
Mutagen
P-element activity
(Edwards and Kiehart, 1996)
Progenitor genotype
sqh1
(Edwards and Kiehart, 1996)
Associated Insertion(s)
P{}sqh2
Cytology
Description

sqh2 is missing most of the P-element and 1.4kb upstream of it, i.e. removing the 5' non-coding portion of the gene.

(Edwards and Kiehart, 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The eye phenotype of rokcat.GMR flies is not suppressed in a sqh2/+ background.

      sqh2/+ does not suppress the wing phenotype of animals expressing rokcat.Scer\UAS under the control of Scer\GAL4en-e16E.

      (Verdier et al., 2006)

      Strong allele. Phenotype is stronger than that of sqh1. Phenotype is no stronger in hemizygotes as compared to homozygotes. Homozygotes die 4-8 days after hatching. When maternal contribution is reduced, sqh2 becomes embryonic lethal, and mutants display phenotypes similar to those of Mhc null mutants.

      (Edwards and Kiehart, 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      sqh2/sqh[+] is an enhancer of visible phenotype of Scer\GAL4en-e16E, kermitGS2053

      (Djiane and Mlodzik, 2010)
      NOT Suppressor of
      Statement
      Reference

      sqh2/sqh[+] is a non-suppressor of visible phenotype of Rokcat.GMR

      (Verdier et al., 2006)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      sqh2/sqh[+] is an enhancer of wing hair phenotype of Scer\GAL4en-e16E, kermitGS2053

      (Djiane and Mlodzik, 2010)
      NOT Enhancer of
      Statement
      Reference

      sqh2/sqh[+] is a non-enhancer of phenotype of ctC145

      (Jackson and Berg, 1999)

      sqh2 is a non-enhancer of phenotype of ctC145

      (Jackson and Berg, 1999)
      Suppressor of
      Statement
      Reference

      sqh2/sqh[+] is a suppressor of aster | embryonic cycle 5 phenotype of CycB+t10

      (Ji et al., 2002)

      sqh2/sqh[+] is a suppressor of aster | embryonic cycle 6 phenotype of CycB+t10

      (Ji et al., 2002)

      sqh2/sqh[+] is a suppressor of aster | embryonic cycle 7 phenotype of CycB+t10

      (Ji et al., 2002)
      NOT Suppressor of
      Statement
      Reference

      sqh2/sqh[+] is a non-suppressor of eye phenotype of Rokcat.GMR

      (Verdier et al., 2006)

      sqh2/sqh[+] is a non-suppressor of crossvein phenotype of Rokcat.UAS.cVa, Scer\GAL4en-e16E

      (Verdier et al., 2006)

      sqh2/sqh[+] is a non-suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB+t10

      (Ji et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      sqh2 shows no interaction with Sbunspecified (assayed in terms of a malformed leg phenotype).

      (Bayer et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      sqh2 is rescued by sqh+t3.0

      (Edwards and Kiehart, 1996)
      Comments

      All phenotypes are completely rescued by sqh+t3.0.

      (Edwards and Kiehart, 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sqh2
      (Djiane and Mlodzik, 2010, Franke et al., 2006, Verdier et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)