FlyBase Allele Report: Dmel\Rok[cat.GMR]

General Information

Symbol

Dmel\Rok^cat.GMR

Species

D. melanogaster

Name

FlyBase ID

FBal0246223

Feature type

allele

Associated gene

Dmel\Rok

Associated Insertion(s)

Carried in Construct

P{GMR-Rok.cat}

Key Links

Transgenic product class

inframe_deletion

(Verdier et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Verdier et al., 2006)

Mutagen

in vitro construct

(Verdier et al., 2006)

Progenitor genotype

Carried in construct

P{GMR-Rok.cat}

Cytology

Description

GMR promoter sequences drive expression of the catalytic domain (amino acids 1-506) of rok.

(Verdier et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Rok

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Verdier et al., 2006)

visible

(Verdier et al., 2006)

Phenotype Manifest In

eye

(Verdier et al., 2006)

photoreceptor neuron

(Verdier et al., 2006)

Detailed Description

Statement

Reference

rok^cat.GMR flies exhibit rough eyes and an overall reduction in size compared to wild-type eyes. Ommatidial structure is dramatically disrupted resulting from cell death, and differentiated photoreceptors in the adult eye are disrupted and collapsed. Third instar larval eye discs show proper axonal guidance and projection of photoreceptors.

(Verdier et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rok^cat.GMR has visible phenotype, enhanceable by LIMK1^GMR.PV

(Verdier et al., 2006)

Suppressed by

Statement

Reference

Rok^cat.GMR has increased cell death phenotype, suppressible by BacA\p35^GMR.PH

(Verdier et al., 2006)

Rok^cat.GMR has visible phenotype, suppressible by hts[+]/hts⁰¹¹⁰³

(Verdier et al., 2006)

Rok^cat.GMR has visible phenotype, suppressible by dia[+]/dia^k07135

(Verdier et al., 2006)

Rok^cat.GMR has visible phenotype, suppressible by zip[+]/zip¹

(Verdier et al., 2006)

Rok^cat.GMR has visible phenotype, suppressible by BacA\p35^GMR.PH

(Verdier et al., 2006)

NOT suppressed by

Statement

Reference

Rok^cat.GMR has visible phenotype, non-suppressible by sqh²/sqh[+]

(Verdier et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rok^cat.GMR has eye phenotype, enhanceable by LIMK1^GMR.PV

(Verdier et al., 2006)

Suppressed by

Statement

Reference

Rok^cat.GMR has eye phenotype, suppressible by hts[+]/hts⁰¹¹⁰³

(Verdier et al., 2006)

Rok^cat.GMR has eye phenotype, suppressible by dia[+]/dia^k07135

(Verdier et al., 2006)

Rok^cat.GMR has eye phenotype, suppressible by zip[+]/zip¹

(Verdier et al., 2006)

Rok^cat.GMR has eye phenotype, suppressible by BacA\p35^GMR.PH

(Verdier et al., 2006)

NOT suppressed by

Statement

Reference

Rok^cat.GMR has eye phenotype, non-suppressible by sqh²/sqh[+]

(Verdier et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The eye phenotype of rok^cat.GMR flies is suppressed in a hts⁰¹¹⁰³/+ or dia^k07135/+ background.

The eye phenotype of rok^cat.GMR flies is suppressed in a zip¹/+ background.

The eye phenotype of rok^cat.GMR flies is not suppressed in a sqh²/+ background.

Expression of LIMK1^GMR.PV in flies expressing rok^cat.GMR results in dramatic disruption of eye development associated with a severe morphology defect of the external eye and a reduced overall eye size.

(Verdier et al., 2006)

Xenogenetic Interactions

Statement

Reference

Expression of BacA\p35^GMR.PH in flies expressing rok^cat.GMR suppresses the mutant retinal phenotype.

(Verdier et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rok^cat.GMR

rok^cat.GMR

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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