FB2026_03 , released September 17, 2026
Allele: Dmel\sced1
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General Information
Symbol
Dmel\sced1
Species
D. melanogaster
Name
FlyBase ID
FBal0032667
Feature type
allele
Associated gene
Dmel\sced
Associated Insertion(s)
P{}sced1
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Sullivan et al., 1993)
Mutagen
P-element activity
(Sullivan et al., 1993)
Progenitor genotype
Associated Insertion(s)
P{}sced1
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Actin is dispersed and mitotic furrows do not form in divisions 10-13 of syncytial blastoderm embryos derived from homozygous females. Microtubules from individual spindle poles often interact with chromosomes on neighbouring spindles, forming microtubule bridges. Small actin caps form during interphase. The processes of pole cell formation, blastoderm cellularisation and postcellularisation mitotic divisions appear to be unaffected in these mutant embryos.

      (Stevenson et al., 2001)

      Embryos derived from sced1 mutant females show severe mitotic defects during divisions 11 to 13.

      (Sibon et al., 1999)

      50% of embryos from homozygous mothers have uneven nuclear migration in nuclear cycles 9 and 10 and all undergo abnormal cortical nuclear divisions prior to cellularization. Affected embryos cellularize with fewer cortical nuclei and an excess of interior nuclei. Affected embryos develop distinct defects in the cortical cytoskeleton.

      (Sullivan et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      sced[+]/sced1 is a suppressor of aster | embryonic cycle 5 phenotype of CycB+t10

      (Ji et al., 2002)

      sced[+]/sced1 is a suppressor of aster | embryonic cycle 6 phenotype of CycB+t10

      (Ji et al., 2002)

      sced[+]/sced1 is a suppressor of aster | embryonic cycle 7 phenotype of CycB+t10

      (Ji et al., 2002)

      sced[+]/sced1 is a suppressor of mitotic domain 1 | embryonic cycle 10 phenotype of CycB+t10

      (Ji et al., 2002)

      sced[+]/sced1 is a suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB+t10

      (Ji et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      sced1 is rescued by sced+t3.9

      (Stevenson et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P-element can revert the mutant phenotype.

      (Stevenson et al., 2001)

      Revertant analysis confirmed that maternal effect is caused by the P-element. The same phenotype is observed in embryos derived from homozygous or hemizygous females.

      (Sullivan et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fs37
      sced1
      Name Synonyms
      Secondary FlyBase IDs
        References (4)