FlyBase Allele Report: Dmel\Wee1[DS1]

General Information

Symbol

Dmel\Wee1^DS1

Species

D. melanogaster

Name

FlyBase ID

FBal0117257

Feature type

allele

Associated gene

Dmel\Wee1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

diepoxybutane

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Price et al., 2000)

Mutagen

diepoxybutane

(Price et al., 2000)

Progenitor genotype

Cytology

Description

Amino acid replacement: F250I.

(Price et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:6,913,036..6,913,036 [-]

Nucleotide change:

T6913036A

Amino acid change:

F250I | Wee1-PA; F250I | Wee1-PB

Reported amino acid change:

F250I|FBrf0127282

Comment:

site of nucleic acid difference inferred by FlyBase curator based on reported amino acid change

(Price et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Price et al., 2000)

lethal - all die during embryonic stage | maternal effect | recessive

(Price et al., 2000)

some die during embryonic stage | recessive | maternal effect | recessive

(Price et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Many embryos derived from homozygous females cellularise (54%) and some even develop to adulthood, whereas embryos derived from hemizygous females rarely cellularise and never hatch. Embryos derived from wee^DS1/wee^ES1 females never cellularise.

(Price et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Wee1^DS1 has phenotype, enhanceable by mei-41[+]/mei-41^D3

(Price et al., 2000)

Wee1^DS1 has phenotype, enhanceable by mei-41^D3/mei-41^D3

(Price et al., 2000)

NOT Enhancer of

Statement

Reference

wee[+]/Wee1^DS1 is a non-enhancer of mitotic domain 1 | embryonic cycle 14 phenotype of CycB^+t10

(Ji et al., 2002)

NOT Suppressor of

Statement

Reference

wee[+]/Wee1^DS1 is a non-suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB^+t10

(Ji et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The incompletely penetrant syncytial arrest phenotype of embryos derived from homozygous wee^DS1 females is enhanced if the females also carry mei-41^D3, so that only 39% of the embryos cellularise if the females carry one copy of mei-41^D3 and only 29% of the embryos cellularise if the females carry two copies of mei-41^D3.

(Price et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3499

w¹; Wee1^DS1 cn¹/CyO, P{ActGFP}JMR1

Kyoto

107070

w¹; Wee1^DS1 cn¹/CyO, P{ActGFP}JMR1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Dwee1^DS1

(Price et al., 2000)

Dwee^DS1

(Ji et al., 2002)

Dwee^DS

(Abdu et al., 2002)

Wee1^DS1

wee^DS1

(Das et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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