FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RPA23
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General Information
Symbol
Dmel\RPA23
Species
D. melanogaster
Name
FlyBase ID
FBal0195214
Feature type
allele
Associated gene
Dmel\RPA2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Crest et al., 2007)
Mutagen
Delta2-3 transposase
(Crest et al., 2007)
Progenitor genotype
RPA2KG00759
(Crest et al., 2007)
Cytology
Description

Imprecise excision of the P{SUPor-P} element which deletes part of the second RPA2 exon plus two exons downstream of the original insertion site (1911bp of genomic DNA are deleted).

(Crest et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes hatch at the same rate as wild-type embryos, but arrest at the second instar with a normal larval cuticle pattern.

      (Crest et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      RPA23/RPA2[+] is a suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB+t10

      (Crest et al., 2007)
      NOT Suppressor of
      Statement
      Reference

      RPA23/RPA2[+] is a non-suppressor of mitotic domain 1 | embryonic cycle 10 phenotype of CycB+t10

      (Crest et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      93% of embryos derived from females carrying four copies of CycB+t10 (as well as two wild-type copies of CycB+) and also heterozygous for RPA23 have a normal phenotype at cycle 14, while only 31% of these embryos have a normal phenotype at cycle 10.

      (Crest et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RPA23
      dRPA23
      (Crest et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)