In wild-type animals, exposure to 40Gy of γ rays induces a distinct pattern of apoptosis in the wing disc, focussed on the the wing pouch, but excluding the DV boundary region and prospective vein. In Dpa4/Dpa2 animals, the same irradiation treatment induces a different pattern of apoptosis, a smaller number of apoptotic cells are clustered in the center of the wing pouch, many in the D-V boundary region or prospective veins. This new pattern of apoptosis is consistent over time and follows the same kinetics as in wild-type. Marker analysis suggests that patterning of the wing disc (including vein and D-V boundary specification) is normal in these animals.
Disrupt G[]-S transcription late in embryogenesis, DNA replication still occurs.
Hemizygotes exhibit kidney-shaped rough eyes, thin and short bristles on the thorax and head and severe abdominal abnormalities.