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General Information
Symbol
Dmel\Dpa4
Species
D. melanogaster
Name
FlyBase ID
FBal0063496
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dDpa4
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In wild-type animals, exposure to 40Gy of γ rays induces a distinct pattern of apoptosis in the wing disc, focussed on the the wing pouch, but excluding the DV boundary region and prospective vein. In Dpa4/Dpa2 animals, the same irradiation treatment induces a different pattern of apoptosis, a smaller number of apoptotic cells are clustered in the center of the wing pouch, many in the D-V boundary region or prospective veins. This new pattern of apoptosis is consistent over time and follows the same kinetics as in wild-type. Marker analysis suggests that patterning of the wing disc (including vein and D-V boundary specification) is normal in these animals.

Disrupt G[[1]]-S transcription late in embryogenesis, DNA replication still occurs.

Hemizygotes exhibit kidney-shaped rough eyes, thin and short bristles on the thorax and head and severe abdominal abnormalities.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

Adult viability of CycD1/Y ; Dpa4/+ males is 67% of expected value. Adult viability of CycD2/Y ; Dpa4/+ males is 61% of expected value.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)