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Citation
Vrailas, A.D., Moses, K. (2006). Smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye.  Mech. Dev. 123(2): 151--165.
FlyBase ID
FBrf0191137
Publication Type
Research paper
Abstract

The Hedgehog and Decapentaplegic pathways have several well-characterized functions in the developing Drosophila compound eye, including initiation and progression of the morphogenetic furrow. Other functions involve control of cell cycle and cell survival as well as cell type specification. Here we have used the mosaic clone analysis of null mutations of the smoothened and thickveins genes (which encode the receptors for these two signals) both alone and in combination, to study cell cycle and cell fate in the developing eye. We conclude that both pathways have several, but differing roles in furrow induction and cell fate and survival, but that neither directly affects cell type specification.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mech. Dev.
    Title
    Mechanisms of Development
    Publication Year
    1990-
    ISBN/ISSN
    0925-4773
    Data From Reference
    Alleles (4)
    Genes (26)
    Transgenic Constructs (2)
    Transcripts (1)