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FB2026_01
,
released March 12, 2026
Cdk4/6, l(2)05428, dCdk4, l(2)s4639, 8-6
a Cdk involved in control of growth of cells - partners cyclin D - governs progression through the G1 phase of the cell cycle - controls intestinal stem cell proliferation and differentiation
Please see the JBrowse view of Dmel\Cdk4 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
1.2 (northern blot)
317 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdk4 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Cdk4 transcripts are detected at all stages of development on northern blots. They are found to be ubiquitous in early embryos by in situ hybridization. They are also present at a low level throughout the embryo at later stages of embryogenesis with stronger signals observed in internal tissues of germ band retracted embryos in a pattern correlated with endoreduplicaiton in these tissues.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Cdk4 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an decrease, an increase in the proportion of S phase cells, an increase in cell size, in the proportion of G2/M phase cells and spindle abnormalities (branched spindles) are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cell size is increased, microtubules are uniform or disorganised, cell shape is irregular, and cell number is decreased indicative of a failure in cell cycle progression through G1 to S and G2 to M stages. This phenotype is not seen in Kc167 cells.
Cdk4 has a role in the modulation of growth rates and is dispensable for cell cycle progression.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
Characterisation of Cdk4.
Isolated from a genomic library using a Pka-C1 probe.
Cdk4 may encode a protein kinase.
Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.
Source for merge of: Cdk4 l(2)s4639
Source for merge of: Cdk4/6 l(2)05428 l(2)k06503
Source for merge of: Cdk4 Pk53C
Source for merge of: Cdk4 l(2)SH0671
Source for identity of: Cdk4/6 CG5072
