FlyBase Gene Report: Dmel\Cdk5

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\Cdk5

General Information

Symbol

Dmel\Cdk5

Species

D. melanogaster

Name

Cyclin-dependent kinase 5

Annotation Symbol

CG8203

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013762

Gene Model Status

Stock Availability

9 publicly available

Enzyme Name (EC)

cyclin-dependent kinase (2.7.11.22)

Gene Summary

Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:15,569,528..15,571,417 [-]

Recombination map

2-74

RefSeq locus

NT_033778 REGION:15569528..15571417

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (20 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables cyclin-dependent protein serine/threonine kinase activity

inferred from direct assay

(Connell-Crowley et al., 2000)

enables protein serine/threonine kinase activity

inferred from direct assay

(Kang et al., 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables cyclin-dependent protein serine/threonine kinase activity

inferred from sequence or structural similarity

(Hellmich et al., 1994)

inferred from biological aspect of ancestor with PANTHER:PTN002373304

(GO Reference Genome Project, 2011-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(InterPro Project Members, 2004-)

Biological Process (12 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in adult locomotory behavior

inferred from mutant phenotype

(Kissler et al., 2009)

involved_in axonogenesis

inferred from mutant phenotype

(Connell-Crowley et al., 2000)

inferred from genetic interaction with FLYBASE:Cdk5α; FB:FBgn0027491

(Connell-Crowley et al., 2000)

involved_in centrosome localization

inferred from mutant phenotype

(Jauffred et al., 2013)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Connell-Crowley et al., 2007)

involved_in flight behavior

inferred from mutant phenotype

(Kissler et al., 2009)

involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

inferred from genetic interaction with FLYBASE:ninaE; FB:FBgn0002940

(Kang et al., 2012)

involved_in melanotic encapsulation of foreign target

inferred from mutant phenotype

(Howell et al., 2012)

involved_in motor neuron axon guidance

inferred from mutant phenotype

(Connell-Crowley et al., 2007)

involved_in regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Kissler et al., 2009)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in axonogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000623852

(GO Reference Genome Project, 2011-)

involved_in neuron apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN000623852

(GO Reference Genome Project, 2011-)

involved_in regulation of cell cycle phase transition

inferred from biological aspect of ancestor with PANTHER:PTN002373304

(GO Reference Genome Project, 2011-)

involved_in synaptic vesicle transport

inferred from biological aspect of ancestor with PANTHER:PTN000623852

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of protein kinase 5 complex

inferred from physical interaction with FLYBASE:Cdk5α; FB:FBgn0027491

(Connell-Crowley et al., 2000)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of cyclin-dependent protein kinase holoenzyme complex

inferred from biological aspect of ancestor with PANTHER:PTN002373304

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN002373304

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000623091

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CYCLIN DEPENDENT KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (P48609)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

cyclin-dependent protein serine/threonine kinase activity

(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.11.22)

(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.11.22)

protein serine/threonine kinase activity

Summaries

Gene Snapshot

Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

CYCLIN DEPENDENT KINASES -: Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory cyclin subunit. (Adapted from PMID:25180339).

Protein Function (UniProtKB)

Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development (By similarity).

(UniProt, P48609)

Summary (Interactive Fly)

a Cdk involved in control of cell differentiation and morphology - regulates developmental remodeling of mushroom body neurons

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Cdk5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P48609)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0087350

1604

294

Additional Transcript Data and Comments

Reported size (kB)

1.6 (northern blot)

(Sauer et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0086483

33.2

294

7.82

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

294 (aa)

(Sauer et al., 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

P48609

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdk5 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cdk5_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.42

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

presumptive embryonic/larval central nervous system

(Sauer et al., 1996)

presumptive embryonic/larval nervous system

(Sauer et al., 1996)

(Sauer et al., 1996)

embryonic stage -- adult stage

(Sauer et al., 1996)

Additional Descriptive Data

Cdk5 transcripts are detected at all stages of development on northern blots. They are found to be ubiquitous in early embryos by in situ hybridization. They are also present at a low level throughout the embryo at later stages of embryogenesis. Stronger signals are observed in the CNS of late embryos.

(Sauer et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Sauer et al., 1996)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Constant levels of Cdk5 protein are observed through embryogenesis by immunoblotting.

(Sauer et al., 1996)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of protein kinase 5 complex

inferred from physical interaction with FLYBASE:Cdk5α; FB:FBgn0027491

(Connell-Crowley et al., 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cdk5 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cdk5

View exonic expression by tissue for Dmel\Cdk5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36727/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013762

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013762

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013762

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8203

Flygut - An atlas of the Drosophila adult midgut

FBgn0013762

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cdk5

Transgenic constructs containing regulatory region of Cdk5

Aberrations (Deficiencies and Duplications) ( 8 )

Inferred from experimentation ( 8 )

Gene disrupted in

(Ryder, 2004.4.26)

(Sauer et al., 1996)

(Sauer et al., 1996)

(Sauer et al., 1996)

(Sauer et al., 1996)

Gene not disrupted in

(Sauer et al., 1996)

(Sauer et al., 1996)

(Sauer et al., 1996)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cdk5^GD13840

viable, with Scer\GAL4^Mef2.PR

Cdk5^GD13840

viable, with Scer\GAL4^pnr-MD237

Cdk5^GD13840

viable, with Scer\GAL4^tin.CΔ4

Cdk5^GD13840

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Cdk5^GL00189

Other Phenotypes

Allele

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^unspecified

Cdk5^{K33A.UAS.Tag:FLAG}

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cdk5^GD13840

short lived, with Scer\GAL4^elav-C155

Phenotype manifest in

Allele

centrosome, with Scer\GAL4^neur-P72

Cdk5^KK109344

external sensory organ precursor cell I, with Scer\GAL4^neur-P72

Cdk5^KK109344

motor neuron | embryonic stage, with Scer\GAL4^unspecified

Cdk5^{K33A.UAS.Tag:FLAG}

presumptive embryonic/larval nervous system, with Scer\GAL4^unspecified

Cdk5^{K33A.UAS.Tag:FLAG}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (60)

13 of 14

Yes

Yes

2

4 of 14

No

No

4 of 14

No

No

1

4 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

5

1 of 14

No

No

1 of 14

No

No

3

1 of 14

No

No

5

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

4

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

3

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

2

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (47)

13 of 14

Yes

Yes

4 of 14

No

No

4 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (51)

13 of 14

Yes

Yes

4 of 14

No

No

4 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (30)

5 of 13

Yes

Yes

3 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Danio rerio (Zebrafish) (56)

12 of 14

Yes

Yes

4 of 14

No

No

4 of 14

No

No

2 of 14

No

No

2 of 14

No

No

2 of 14

No

Yes

2 of 14

No

No

2 of 14

No

Yes

Drer\LOC100536316

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Drer\LOC101885029

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Drer\si:ch73-60h1.1

1 of 14

No

No

Drer\si:ch211-27e6.1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (29)

12 of 14

Yes

Yes

4 of 14

No

No

4 of 14

No

No

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (26)

Agam\AgaP_AGAP005772

11 of 12

Yes

Yes

Agam\AgaP_AGAP004579

3 of 12

No

No

Agam\AgaP_AGAP009459

3 of 12

No

No

Agam\AgaP_AGAP005729

2 of 12

No

No

Agam\AgaP_AGAP000070

1 of 12

No

No

Agam\AgaP_AGAP002075

1 of 12

No

No

Agam\AgaP_AGAP002110

1 of 12

No

No

Agam\AgaP_AGAP002646

1 of 12

No

No

Agam\AgaP_AGAP003180

1 of 12

No

No

Agam\AgaP_AGAP004443

1 of 12

No

No

Agam\AgaP_AGAP004594

1 of 12

No

No

Agam\AgaP_AGAP004780

1 of 12

No

No

Agam\AgaP_AGAP005306

1 of 12

No

No

Agam\AgaP_AGAP005569

1 of 12

No

No

Agam\AgaP_AGAP005817

1 of 12

No

No

Agam\AgaP_AGAP005851

1 of 12

No

No

Agam\AgaP_AGAP006340

1 of 12

No

No

Agam\AgaP_AGAP008541

1 of 12

No

No

Agam\AgaP_AGAP009034

1 of 12

No

No

Agam\AgaP_AGAP009936

1 of 12

No

No

Agam\AgaP_AGAP010115

1 of 12

No

No

Agam\AgaP_AGAP010874

1 of 12

No

No

Agam\AgaP_AGAP011055

1 of 12

No

No

Agam\AgaP_AGAP011297

1 of 12

No

No

Agam\AgaP_AGAP011710

1 of 12

No

No

Agam\AgaP_AGAP012148

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (81)

4 of 13

Yes

No

3 of 13

No

No

3 of 13

No

No

3 of 13

No

No

3 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Saccharomyces cerevisiae (Brewer's yeast) (19)

6 of 13

Yes

Yes

3 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Schizosaccharomyces pombe (Fission yeast) (18)

6 of 12

Yes

Yes

3 of 12

No

No

2 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cdk5. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (32)

6 of 13

6 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CDK5; cyclin dependent kinase 5

model of lissencephaly 7 with cerebellar hypoplasia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

Cdk5^UAS.Tag:FLAG

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Saito et al., 2019)

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}

(Liman et al., 2014)

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Liman et al., 2014)

ameliorates retinal disease

modeled by ninaE^G69D.UAS

(Kang et al., 2012)

ameliorates retinitis pigmentosa

modeled by ninaE^G69D.UAS

(Chow et al., 2016)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Saito et al., 2019)

Cdk5^RNAi.UAS.cUa

ameliorates brain cancer

modeled by brat^RNAi.UAS.cUa

(Mukherjee et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CDK5; cyclin dependent kinase 5

13 of 14

LISSENCEPHALY 7 WITH CEREBELLAR HYPOPLASIA; LIS7

lissencephaly 7 with cerebellar hypoplasia

CDK1; cyclin dependent kinase 1

4 of 14

CDK2; cyclin dependent kinase 2

4 of 14

CDK3; cyclin dependent kinase 3

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pull down, autoradiography

(Connell-Crowley et al., 2000)

enzymatic study, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Kang et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Connell-Crowley et al., 2000)

suppressible

(Connell-Crowley et al., 2000)

suppressible

(Park et al., 2023, Kang et al., 2012)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62461

DroID - A comprehensive database of gene and protein interactions.

FBgn0013762

MIST (genetic) - An integrated Molecular Interaction Database

36727

MIST (protein-protein) - An integrated Molecular Interaction Database

36727

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P48609

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-74

Cytogenetic map

Sequence location

2R:15,569,528..15,571,417 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

52A13-52A13

Limits computationally determined from genome sequence between P{lacW}Vha36^k07207 and P{lacW}l(2)k05713^k05713

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

52A-52A

(Lehner, 1996.7.23)

52A14-52C9

(determined by in situ hybridisation)

(Hellmich et al., 1994)

Experimentally Determined Recombination Data

Location

2-74

(FlyBase, 2016)

2-78.7

(Comeron et al., 2012)

2-

(Lehner, 1996.7.23)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

27517

y¹ v¹; P{TRiP.JF02667}attP2

35287

y¹ v¹; P{TRiP.GL00189}attP2

94447

w^*; TI{CRIMIC.TG4.2}Cdk5^{CR60430-TG4.2} CG30466^{CR60430-TG4.2-X}/CyO

8203R-1

8203R-3

2RG-1490

y² VhaAC39-1^cho-1 v¹; P{U6-Cdk5.NIG.sgRNA}attP40/CyO

v104491

P{KK109344}VIE-260B

v35855

w¹¹¹⁸; P{GD13840}v35855

v342015

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01369}attP40/CyO-GFP

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (17)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD01910

Other clones

DPiM_LD01910

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0013762

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0013762

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Sauer et al., 1996)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R⁺ cells: cell morphology is aberrant and there is an increased frequency of microtubule-based mitotic spindles, indicative of a failure in mitosis.

(Kiger et al., 2003)

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

(Rogers et al., 2003)

Promoter structures of Flo abut to or overlap with the 3'UTR of Cdk5. Overall orientation not stated: Cdk5+ Flo+

(Hoehne et al., 1999)

Characterisation of Cdk5.

(Sauer et al., 1996)

Isolated from a genomic library, using a rat CDK5 cDNA as a probe.

(Hellmich et al., 1994)

Cdk5 has been cloned and sequenced.

(Hellmich et al., 1994)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Cdk5 CG8203

(Li, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CDK5

(Palu et al., 2020, Bouleau and Tricoire, 2015, Ryoo, 2015, Choksi et al., 2014, Lin et al., 2010, Choe et al., 2007, Rascle et al., 2003, Shulman and Feany, 2003, Bellen, 2000.12.25, Hellmich, 1995.2.23)

CG8203

(National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Howell et al., 2012, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Kissler et al., 2009, Perkins et al., 2009, Haussmann et al., 2008, Rogers et al., 2003, Morrison et al., 2000, Verstreken and Bellen, 2000.9.4)

DmCdk5

(Kolonin and Finley, 1998)

cdk5

(Arora and Ligoxygakis, 2020, Di Cara et al., 2015, Jauffred et al., 2013, Kang et al., 2012, Mudiganti et al., 2010, Kissler et al., 2009, Hoehne et al., 1999, Lehner, 1996.7.23, Sauer et al., 1996)

Name Synonyms

Cyclin-dependent kinase 5

(Nandi et al., 2022, Liman et al., 2014, Kissler et al., 2009, Rogers et al., 2003)

cyclin-dependent kinase 5

(Engel et al., 2016, Chau et al., 2006)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36727

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P48609

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P48609

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P48609

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36727/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013762

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013762

FlyMine - An integrated database for Drosophila genomics

FBgn0013762

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8203

MARRVEL_MODEL - MARRVEL (model organism gene)

36727

Linkouts

BioGRID - A database of protein and genetic interactions.

62461

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0013762

DroID - A comprehensive database of gene and protein interactions.

FBgn0013762

DRSC - Results frm RNAi screens

FBgn0013762

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cdk5_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013762

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0013762

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8203

Flygut - An atlas of the Drosophila adult midgut

FBgn0013762

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0013762

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009740

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

36727

MIST (protein-protein) - An integrated Molecular Interaction Database

36727

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P48609

References (121)