FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

ID (Ontology)

GO:0070059 (Gene Ontology)

Definition

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.[ PubMed:18701708 ]

Also Known As

"apoptosis in response to ER stress" ; "apoptosis triggered by ER stress" ; "endoplasmic reticulum stress-induced apoptosis" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (all annotations which use CV term, excluding "NOT" statements)
involved_in \| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Spanning Tree (Parents/Children)

cellular response to stress
 |__response to endoplasmic reticulum stress__
intracellular signal transduction             |
 |__intrinsic apoptotic signaling pathway_____|
apoptotic signaling pathway                   |
 |__intrinsic apoptotic signaling pathway_____|
                                              intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  6 rec.
                                               |__neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                               |   |__regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(+)
                                               |__regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2 rec.
                                                   |__negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(+) 1 rec.
                                                   |__positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1 rec.
                                                   |__regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(+)

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms
	"apoptosis in response to endoplasmic reticulum stress" BROAD "apoptosis in response to ER stress" EXACT "apoptosis triggered by ER stress" EXACT "endoplasmic reticulum stress-induced apoptosis" EXACT "ER stress-induced apoptosis" EXACT "intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT
Secondary IDs

External Crossreferences & Linkouts