FB2026_03 , released September 17, 2026
CV Term Report
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Term cyclin-dependent protein serine/threonine kinase activity ID (Ontology) GO:0004693 (Gene Ontology)
Definition Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.[ PubMed:7877684 PubMed:9841670 ]
Also Known As"CDK activity" ; "CDK, catalytic subunit activity" ; "cyclin-dependent protein kinase, intrinsic catalyst activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 cyclin-dependent protein serine/threonine kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | cyclin-dependent protein serine/threonine kinase activity       --
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protein kinase activity
 |__protein serine/threonine kinase activity__
 |__cyclin-dependent protein kinase activity__|
                                              cyclin-dependent protein serine/threonine kinase activity  18 rec.
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Is a protein serine/threonine kinase activity
cyclin-dependent protein kinase activity
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Synonyms
  • "ATP:cyclin phosphotransferase activity" RELATED[ EC:2 ]
    "cdc2 kinase activity" NARROW[ EC:2 ]
    "CDK" RELATED[ EC:2 ]
    "CDK activity" EXACT
    "CDK, catalytic subunit activity" EXACT
    "cdk-activating kinase activity" RELATED[ EC:2 ]
    "Cdk-activating protein kinase activity" RELATED[ EC:2 ]
    "cyclin D-cdk6 kinase activity" NARROW[ EC:2 ]
    "cyclin D-dependent kinase activity" NARROW[ EC:2 ]
    "cyclin E kinase activity" NARROW[ EC:2 ]
    "cyclin-A associated kinase activity" NARROW[ EC:2 ]
    "cyclin-dependent kinase 6 activity" NARROW[ EC:2 ]
    "cyclin-dependent kinase activity" BROAD[ EC:2 ]
    "cyclin-dependent kinase-2 activity" NARROW[ EC:2 ]
    "cyclin-dependent kinase-4 activity" NARROW[ EC:2 ]
    "cyclin-dependent protein kinase activity" BROAD
    "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT
    "D-type cyclin kinase activity" NARROW[ EC:2 ]
    "neuronal cdc2-like kinase activity" NARROW[ EC:2 ]
Secondary IDs
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EC:2.7.11.22
Reactome:R-HSA-1226094 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex"
Reactome:R-HSA-1226095 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex"
Reactome:R-HSA-174079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
Reactome:R-HSA-174122 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2"
Reactome:R-HSA-174132 "Free APC/C phosphorylated by Cyclin B:Cdc2"
Reactome:R-HSA-174251 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
Reactome:R-HSA-180047 "CDK5 phosphorylates DARPP-32 on Thr75"
Reactome:R-HSA-187520 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21"
Reactome:R-HSA-187916 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21"
Reactome:R-HSA-187948 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2"
Reactome:R-HSA-187959 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)"
Reactome:R-HSA-188390 "Cyclin E:CDK2-mediated phosphorylation of RB1"
Reactome:R-HSA-1912391 "NICD1 is phosphorylated by CDK8"
Reactome:R-HSA-2172183 "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB"
Reactome:R-HSA-2220971 "CDK8 phosphorylates NICD1 PEST domain mutants"
Reactome:R-HSA-2245218 "CDK1 phosphorylates PHF8"
Reactome:R-HSA-2294600 "CDK1 phosphorylates condensin II subunit NCAPD3"
Reactome:R-HSA-2430533 "CDK1 phosphorylates MASTL"
Reactome:R-HSA-2468287 "CDK1 phosphorylates CDCA5 (Sororin) at centromeres"
Reactome:R-HSA-2468293 "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms"
Reactome:R-HSA-2514854 "CDK1 phosphorylates condensin I"
Reactome:R-HSA-2984220 "CDK1:CCNB phosphorylates NEK9"
Reactome:R-HSA-2990882 "CDK1 phosphorylates NUP98"
Reactome:R-HSA-3788705 "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2"
Reactome:R-HSA-380278 "CCNB1:p-T160-CDK1 phosphorylates NUMA1"
Reactome:R-HSA-4086410 "CCNB:CDK1 phosphorylates BORA"
Reactome:R-HSA-4088024 "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1"
Reactome:R-HSA-5195402 "CDK1 phosphorylates LPIN"
Reactome:R-HSA-5244669 "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments"
Reactome:R-HSA-5692755 "CDK1 phosphorylates MAPK6"
Reactome:R-HSA-6793661 "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218"
Reactome:R-HSA-6797606 "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes"
Reactome:R-HSA-6805109 "CDK2 phosphorylates TP53"
Reactome:R-HSA-68944 "Orc1 is phosphorylated by cyclin A/CDK2"
Reactome:R-HSA-69005 "Cdc6 protein is phosphorylated by CDK"
Reactome:R-HSA-69227 "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes"
Reactome:R-HSA-9008412 "CDK4 phosphorylates RUNX2"
Reactome:R-HSA-9009282 "CDK1 phosphorylates RUNX2"
Reactome:R-HSA-9624800 "CDK1 phosphorylates LBR"
Reactome:R-HSA-9686521 "CDK2:CCNA phosphorylates TERF2"
Reactome:R-HSA-9929482 "CDK4:CCND1 phosphorylates SPOP"
Reactome:R-HSA-9929514 "CDK1 phosphorylates CCNA"
Reactome:R-HSA-9929532 "CCNA:CDK1 phosphorylates BORA"
Reactome:R-HSA-9929535 "CCNA:CDK1 phosphorylates WEE1"
Reactome:R-HSA-9929717 "CCNA:CDK1 phosphorylates FZR1"
Reactome:R-HSA-9929719 "CCNA:CDK1 phosphorylates TICRR"
Reactome:R-HSA-9929720 "CCNA:CDK1 phosphorylates OBI1"
Reactome:R-HSA-9929721 "CCNA:CDK1 phosphorylates SGO1 "
Reactome:R-HSA-9929884 "CCNA:CDK1 phosphorylates HJURP"
Reactome:R-HSA-9929904 "CCNA:CDK1 phosphorylates MIS18BP1"
Reactome:R-HSA-9929935 "CCNA:CDK1 phosphorylates CDC25B"