FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cdk5KK109344
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General Information
Symbol
Dmel\Cdk5KK109344
Species
D. melanogaster
Name
FlyBase ID
FBal0236248
Feature type
allele
Associated gene
Dmel\Cdk5
Associated Insertion(s)
Carried in Construct
P{KK109344}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK109344}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK109344
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  retinitis pigmentosa
      modeled by ninaEG69D.UAS
      (Chow et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Cdk5KK109344 under the control of Scer\GAL4GMR.PF has no effect on the adult eye morphology.

      (Chow et al., 2016)

      Centrosome asymmetry during cytokinesis is almost completely lost in pI (sensory organ precursor) cells in the notum expressing Cdk5KK109344 under the control of Scer\GAL4neur-P72.

      (Jauffred et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Cdk5KK109344, Scer\GAL4GMR.PF, ninaEG69D.UAS has eye phenotype, non-enhanceable by superdeathHMS02640, Scer\GAL4GMR.PF

      (Palu et al., 2020)
      NOT suppressed by
      Statement
      Reference

      Cdk5KK109344, Scer\GAL4GMR.PF, ninaEG69D.UAS has eye phenotype, non-suppressible by superdeathHMS02640, Scer\GAL4GMR.PF

      (Palu et al., 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small eye size characteristic for adult flies expressing ninaEG69D.Scer\UAS under the control of Scer\GAL4GMR.PF is not changed by co-expression of Cdk5KK109344, however the pigmentation defect is significantly improved.

      (Chow et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cdk5 KD
      (Chow et al., 2016)
      Cdk5KK109344
      Name Synonyms
      Secondary FlyBase IDs
        References (4)