FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Eip63E
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General Information
Symbol
Dmel\Eip63E
Species
D. melanogaster
Name
Ecdysone-induced protein 63E
Annotation Symbol
CG10579
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005640
Gene Model Status
Current
Stock Availability
22 publicly available
Enzyme Name (EC)
cyclin-dependent kinase (2.7.11.22)
Gene Summary
Ecdysone-induced protein 63E (Eip63E) encodes a cyclin-dependent kinase that interacts with the product of CycY. It contributes to embryogenesis, larval development and metamorphosis. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)
All Summaries
Also Known As

L63, PFTAIRE, cdc2-63E

Key Links
Genomic Location
Cytogenetic map
63E3-63E5
Sequence location
Recombination map
3-8
RefSeq locus
NT_037436 REGION:3515751..3610521
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables cyclin binding
inferred from mutant phenotype
(Stowers et al., 2000)
enables cyclin-dependent protein serine/threonine kinase activity
inferred from mutant phenotype
(Stowers et al., 2000)
inferred from direct assay
(Davidson et al., 2009)
enables protein binding
inferred from physical interaction with FLYBASE:Pif2; FB:FBgn0046873
(Rascle et al., 2003)
inferred from physical interaction with FLYBASE:Pif1B; FB:FBgn0046874
(Rascle et al., 2003)
enables protein kinase activity
inferred from direct assay
(Rascle et al., 2003)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(InterPro Project Members, 2004-)
enables cyclin-dependent protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002373304
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with SGD:S000000364
(Stowers et al., 2000)
enables heme binding
inferred from electronic annotation with InterPro:IPR018506
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271
(InterPro Project Members, 2004-)
enables protein serine/threonine kinase activity
inferred from sequence or structural similarity with UniProtKB:Q00536
(Sauer et al., 1996)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in developmental growth
inferred from mutant phenotype
(Liu and Finley, 2010)
involved_in embryonic development via the syncytial blastoderm
inferred from mutant phenotype
(Stowers et al., 2000)
involved_in instar larval development
inferred from mutant phenotype
(Stowers et al., 2000)
involved_in metamorphosis
inferred from mutant phenotype
(Stowers et al., 2000)
involved_in morphogenesis of an epithelium
inferred from mutant phenotype
(Stowers et al., 2000)
involved_in positive regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Davidson et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of cell cycle phase transition
inferred from biological aspect of ancestor with PANTHER:PTN002373304
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in plasma membrane
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of cyclin-dependent protein kinase holoenzyme complex
inferred from biological aspect of ancestor with PANTHER:PTN002373304
(GO Reference Genome Project, 2011-)
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002373304
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000623091
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.11.22)
(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.11.22)
Summaries
Gene Snapshot
Ecdysone-induced protein 63E (Eip63E) encodes a cyclin-dependent kinase that interacts with the product of CycY. It contributes to embryogenesis, larval development and metamorphosis. [Date last reviewed: 2019-08-01]
Gene Group (FlyBase)
CYCLIN DEPENDENT KINASES -
Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory cyclin subunit. (Adapted from PMID:25180339).
Pathway (FlyBase)
POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -
Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).
Summary (Interactive Fly)

cyclin dependent kinase that plays a role in cell differentiation rather than in cell division

Gene Model and Products
Number of Transcripts
14
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\Eip63E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9PE01)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Eip63E-RA
FBtr0073133
NM_168034
2700
509
Eip63E-RB
FBtr0073134
NM_168035
2919
509
Eip63E-RC
FBtr0073135
NM_168036
2891
509
Eip63E-RD
FBtr0073131
NM_079180
3575
522
Eip63E-RE
FBtr0073132
NM_168033
2981
522
Eip63E-RF
FBtr0110920
NM_001043116
3536
509
Eip63E-RG
FBtr0110921
NM_001043120
2958
522
Eip63E-RH
FBtr0110922
NM_001043117
2625
501
Eip63E-RI
FBtr0110923
NM_001043119
2739
522
Eip63E-RJ
FBtr0110924
NM_001043121
4769
509
Eip63E-RK
FBtr0110925
NM_001043118
2930
522
Eip63E-RL
FBtr0301948
NM_001169869
3311
522
Eip63E-RM
FBtr0302598
NM_001202113
4914
509
Eip63E-RN
FBtr0330068
NM_001274444
3575
538
Additional Transcript Data and Comments
Reported size (kB)

3.4 (northern blot)

(Sauer et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Eip63E-PA
FBpp0072992
58.5
509
8.88
Q7KM05
NP_728889
AAG22238
Eip63E-PB
FBpp0072993
58.5
509
8.88
Q7KM05
NP_728890
AAF47781
Eip63E-PC
FBpp0072994
58.5
509
8.88
Q7KM05
NP_728891
AAG22239
Eip63E-PD
FBpp0072990
59.8
522
8.87
Q9XTK9
NP_523904
AAN11568
Eip63E-PE
FBpp0072991
59.8
522
8.87
Q9XTK9
NP_728888
AAN11569
Eip63E-PF
FBpp0110220
58.3
509
8.88
Q7KM08
NP_001036581
ABI31232
Eip63E-PG
FBpp0110221
59.9
522
8.87
Q7KM03
NP_001036585
ABI31236
Eip63E-PH
FBpp0110222
57.7
501
8.88
Q7KM04
NP_001036582
ABI31233
Eip63E-PI
FBpp0110223
59.9
522
8.87
Q7KM03
NP_001036584
ABI31235
Eip63E-PJ
FBpp0110224
58.5
509
8.88
Q7KM05
NP_001036586
ABI31237
Eip63E-PK
FBpp0110225
59.9
522
8.87
Q7KM03
NP_001036583
ABI31234
Eip63E-PL
FBpp0291160
59.9
522
8.87
Q7KM03
NP_001163340
ACZ94612
Eip63E-PM
FBpp0291754
58.3
509
8.88
Q7KM08
NP_001189042
ADV37479
Eip63E-PN
FBpp0303101
61.6
538
9.03
M9PE01
NP_001261373
AGB94068
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

509 aa isoforms: Eip63E-PF, Eip63E-PM
522 aa isoforms: Eip63E-PG, Eip63E-PI, Eip63E-PK, Eip63E-PL
509 aa isoforms: Eip63E-PA, Eip63E-PB, Eip63E-PC, Eip63E-PJ
522 aa isoforms: Eip63E-PD, Eip63E-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

509 (aa)

(Sauer et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Eip63E using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.25

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
posterior midgut primordium
(Sauer et al., 1996)
anterior midgut primordium
(Sauer et al., 1996)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval central nervous system
(Sauer et al., 1996)
glial cell
(Sauer et al., 1996)
tracheal precursor cell
(Sauer et al., 1996)
myoblast
(Sauer et al., 1996)
larval glial cell
(Sauer et al., 1996)
embryonic stage -- adult stage
(Sauer et al., 1996)
Additional Descriptive Data

Eip63E transcripts are detected at all stages of development on northern blots. They are found to be ubiquitous in early embryos by in situ hybridization. They are also present at a low level throughout the embryo at later stages of embryogenesis. Transient strong signals were observed in a number of tissues. These include the anterior and posterior midguts (in cells rearranging cell-cell contacts), tracheal precursors (during invagination), myoblasts (during fusion), and discrete cells of the CNS (which may be migrating glia).

(Sauer et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in plasma membrane
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: PBac{681.P.FSVS-1}Eip63ECPTI001272
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted

Comment: not in mushroom body and central complex

(Knowles-Barley, 2011.8.24)
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Eip63E in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 45 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Eip63E
Transgenic constructs containing regulatory region of Eip63E
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Eip63E81)
lethal (with Eip63EGN50)
lethal | maternal effect (with Eip63EE1)
lethal | maternal effect (with Eip63EGN50)
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage (with Eip63E81)
lethal - all die before end of P-stage (with Eip63EGN50)
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die | nutrition conditional, with Scer\GAL4Ubi.PU
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable (with Df(3L)1-11)
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
fertile
Other Phenotypes
Allele
abnormal developmental rate (with Eip63E81)
abnormal developmental rate (with Eip63EGN50)
abnormal flight, with Scer\GAL4Mef2.PR
abnormal starvation stress response | adult stage, with Scer\GAL4NP0001
decreased body size (with Eip63EE1)
decreased body size (with Eip63EGN50)
decreased body size | pupal stage (with Eip63E81)
decreased body size | pupal stage (with Eip63EGN50)
majority die during larval stage (with Eip63E81)
majority die during larval stage (with Eip63EGN50)
majority die during larval stage | nutrition conditional, with Scer\GAL4Ubi.PU
short lived | calorie restriction conditional, with Scer\GAL4NP0001
some die during larval stage | recessive
some die during P-stage (with Eip63E81)
some die during P-stage (with Eip63EGN50)
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage (with Eip63E81)
some die during pupal stage (with Eip63EGN50)
visible, with Scer\GAL4pnr-MD237
wild-type
Phenotype manifest in
Allele
head | pupal stage (with Eip63E81)
head | pupal stage (with Eip63EGN50)
leg (with Df(3L)663)
leg | pupal stage (with Eip63E81)
leg | pupal stage (with Eip63EGN50)
mesonotum, with Scer\GAL4pnr-MD237
myofibril, with Scer\GAL4Mef2.PR
polytene chromosome
pupa (with Eip63E81)
pupa (with Eip63EGN50)
sarcomere, with Scer\GAL4Mef2.PR
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (23)
Hsap\CDK14
12 of 14
Yes
Yes
Hsap\CDK15
10 of 14
No
Yes
Hsap\CDK1
3 of 14
No
No
Hsap\CDK2
3 of 14
No
No
1  
Hsap\CDK3
3 of 14
No
No
Hsap\CDK16
3 of 14
No
Yes
Hsap\CDK17
3 of 14
No
Yes
Hsap\CDK18
3 of 14
No
Yes
Hsap\CDK4
2 of 14
No
No
1  
Hsap\CDK5
2 of 14
No
No
2  
Hsap\CDK6
2 of 14
No
No
1  
Hsap\CDK7
1 of 14
No
No
Hsap\CDK9
1 of 14
No
No
1  
Hsap\CDK10
1 of 14
No
No
Hsap\CDK11A
1 of 14
No
No
Hsap\CDK11B
1 of 14
No
No
Hsap\CDK20
1 of 14
No
No
Hsap\MARK2
1 of 14
No
No
3  
Hsap\MARK4
1 of 14
No
No
4  
Hsap\SCYL1
1 of 14
No
No
Hsap\SCYL2
1 of 14
No
No
Hsap\SCYL3
1 of 14
No
No
Hsap\TSSK2
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (17)
Rnor\Cdk15
10 of 14
Yes
Yes
Rnor\Cdk14
8 of 14
No
Yes
Rnor\Cdk1
3 of 14
No
No
Rnor\Cdk2
3 of 14
No
No
Rnor\Cdk16
3 of 14
No
Yes
Rnor\Cdk17
3 of 14
No
Yes
Rnor\Cdk5
2 of 14
No
No
Rnor\Cdk18
2 of 14
No
Yes
Rnor\Cdk4
1 of 14
No
No
Rnor\Cdk6
1 of 14
No
No
Rnor\Cdk11b
1 of 14
No
No
Rnor\Mark2
1 of 14
No
No
Rnor\Mark3
1 of 14
No
No
Rnor\Mark4
1 of 14
No
No
Rnor\Scyl1
1 of 14
No
No
Rnor\Scyl2
1 of 14
No
No
Rnor\Scyl3
1 of 14
No
No
Mus musculus (laboratory mouse) (30)
Mmus\Cdk14
12 of 14
Yes
Yes
Mmus\Cdk15
8 of 14
No
Yes
Mmus\Cdk1
3 of 14
No
No
Mmus\Cdk2
3 of 14
No
No
Mmus\Cdk16
3 of 14
No
Yes
Mmus\Cdk17
3 of 14
No
Yes
Mmus\Cdk18
3 of 14
No
Yes
Mmus\Cdk5
2 of 14
No
No
Mmus\Cdk3
1 of 14
No
No
Mmus\Cdk4
1 of 14
No
No
Mmus\Cdk6
1 of 14
No
No
Mmus\Cdk11b
1 of 14
No
No
Mmus\E030030I06Rik
1 of 14
No
Yes
Mmus\Gm4513
1 of 14
No
Yes
Mmus\Gm4565
1 of 14
No
Yes
Mmus\Gm4567
1 of 14
No
No
Mmus\Gm4922
1 of 14
No
No
Mmus\Gm5157
1 of 14
No
No
Mmus\Gm5890
1 of 14
No
Yes
Mmus\Gm5891
1 of 14
No
No
Mmus\Gm6176
1 of 14
No
No
Mmus\Gm6882
1 of 14
No
No
Mmus\Gm6902
1 of 14
No
Yes
Mmus\Gm10662
1 of 14
No
No
Mmus\Gm10668
1 of 14
No
No
Mmus\Mark2
1 of 14
No
No
Mmus\Mark4
1 of 14
No
No
Mmus\Scyl1
1 of 14
No
No
Mmus\Scyl2
1 of 14
No
No
Mmus\Scyl3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\cdk14
10 of 13
Yes
Yes
Xtro\cdk15
7 of 13
No
Yes
Xtro\cdk1
2 of 13
No
No
Xtro\cdk16
2 of 13
No
Yes
Xtro\cdk2
1 of 13
No
No
Xtro\cdk5
1 of 13
No
No
Xtro\cdk9
1 of 13
No
No
Xtro\cdk17
1 of 13
No
No
Xtro\cdk18
1 of 13
No
Yes
Xtro\mark2
1 of 13
No
No
Xtro\mark4
1 of 13
No
No
Xtro\rtn4
1 of 13
No
No
Xtro\scyl1
1 of 13
No
No
Xtro\scyl2
1 of 13
No
No
Xtro\scyl3
1 of 13
No
No
Xtro\XB5896327
1 of 13
No
Yes
Danio rerio (Zebrafish) (16)
Drer\cdk15
11 of 14
Yes
Yes
Drer\cdk14
9 of 14
No
Yes
Drer\cdk1
3 of 14
No
No
Drer\cdk2
3 of 14
No
No
Drer\cdk17
3 of 14
No
Yes
Drer\cdk5
2 of 14
No
No
Drer\cdk16
2 of 14
No
Yes
Drer\cdk18
2 of 14
No
Yes
Drer\LOC100536316
2 of 14
No
Yes
Drer\cdk4
1 of 14
No
No
Drer\cdk6
1 of 14
No
No
Drer\cdk21
1 of 14
No
No
Drer\mark4b
1 of 14
No
No
Drer\scyl1
1 of 14
No
No
Drer\scyl2
1 of 14
No
No
Drer\scyl3
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\cdk-14
6 of 14
Yes
Yes
Cele\pct-1
5 of 14
No
Yes
Cele\cdk-2
4 of 14
No
No
Cele\cdk-1
3 of 14
No
No
Cele\cdk-5
2 of 14
No
No
Cele\cdk-7
1 of 14
No
No
Cele\cdk-11.1
1 of 14
No
No
Cele\cdk-12
1 of 14
No
No
Cele\sad-1
1 of 14
No
No
Cele\scyl-1
1 of 14
No
No
Cele\Y43D4A.6
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (15)
Agam\AgaP_AGAP005729
12 of 12
Yes
Yes
Agam\AgaP_AGAP004579
3 of 12
No
No
Agam\AgaP_AGAP009459
3 of 12
No
No
Agam\AgaP_AGAP005772
2 of 12
No
No
Agam\AgaP_AGAP005817
2 of 12
No
No
Agam\AgaP_AGAP001091
1 of 12
No
No
Agam\AgaP_AGAP002142
1 of 12
No
No
Agam\AgaP_AGAP002646
1 of 12
No
No
Agam\AgaP_AGAP004780
1 of 12
No
No
Agam\AgaP_AGAP005207
1 of 12
No
No
Agam\AgaP_AGAP005851
1 of 12
No
No
Agam\AgaP_AGAP008354
1 of 12
No
No
Agam\AgaP_AGAP009032
1 of 12
No
No
Agam\AgaP_AGAP010874
1 of 12
No
No
Agam\AgaP_AGAP011055
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (28)
Atha\CDC2
3 of 13
Yes
No
Atha\CDKB1;1
3 of 13
Yes
No
Atha\CDKB1;2
3 of 13
Yes
No
Atha\CDKB2;1
3 of 13
Yes
No
Atha\CDKB2;2
3 of 13
Yes
No
Atha\AT1G22870
1 of 13
No
No
Atha\AT1G53050
1 of 13
No
No
Atha\AT1G67580
1 of 13
No
No
Atha\AT1G71410
1 of 13
No
No
Atha\AT1G71530
1 of 13
No
No
Atha\AT3G05050
1 of 13
No
No
Atha\AT4G19110
1 of 13
No
No
Atha\AT5G45430
1 of 13
No
No
Atha\AT5G63370
1 of 13
No
No
Atha\CAK1AT
1 of 13
No
Yes
Atha\CAK4
1 of 13
No
No
Atha\CDKC2
1 of 13
No
No
Atha\CDKC;1
1 of 13
No
No
Atha\CDKD1;1
1 of 13
No
No
Atha\CDKD1;3
1 of 13
No
No
Atha\CDKE;1
1 of 13
No
No
Atha\CIPK18
1 of 13
No
Yes
Atha\CIPK22
1 of 13
No
Yes
Atha\CIPK26
1 of 13
No
No
Atha\CTEXP
1 of 13
No
No
Atha\ORG1
1 of 13
No
Yes
Atha\STN7
1 of 13
No
No
Atha\STN8
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (14)
Scer\PHO85
5 of 13
Yes
No
Scer\CDC28
2 of 13
No
No
Scer\CAK1
1 of 13
No
No
Scer\CEX1
1 of 13
No
No
Scer\CTK1
1 of 13
No
No
Scer\HAL5
1 of 13
No
No
Scer\KIN28
1 of 13
No
No
Scer\NPR1
1 of 13
No
No
Scer\PRR2
1 of 13
No
No
Scer\PTK1
1 of 13
No
No
Scer\PTK2
1 of 13
No
No
Scer\RTK1
1 of 13
No
No
Scer\SAT4
1 of 13
No
No
Scer\SCY1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (10)
Spom\cdc2
2 of 12
Yes
No
Spom\pef1
2 of 12
Yes
No
Spom\cdr2
1 of 12
No
No
Spom\csk1
1 of 12
No
No
Spom\hal4
1 of 12
No
No
Spom\oca2
1 of 12
No
No
Spom\ppk3
1 of 12
No
No
Spom\ppk23
1 of 12
No
No
Spom\ppk32
1 of 12
No
No
Spom\SPCC70.05c
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Eip63E. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (19)
Cdk1
5 of 13
Cdk2
5 of 13
Cdk4
4 of 13
Cdk5
4 of 13
Cdk7
3 of 13
Cdk12
3 of 13
CG6800
3 of 13
Pitslre
3 of 13
Cdc2rk
2 of 13
Cdk8
2 of 13
Cdk9
2 of 13
Cdkl
2 of 13
Pk34A
2 of 13
Prp4k
2 of 13
CG1344
1 of 13
CG1951
1 of 13
mbt
1 of 13
par-1
1 of 13
yata
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 4 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CDK14; cyclin dependent kinase 14
    12 of 14
    610679
        CDK15; cyclin dependent kinase 15
        10 of 14
        616147
            CDK1; cyclin dependent kinase 1
            3 of 14
            116940
                CDK2; cyclin dependent kinase 2
                3 of 14
                116953
                     
                    CDK3; cyclin dependent kinase 3
                    3 of 14
                    123828
                        CDK16; cyclin dependent kinase 16
                        3 of 14
                        311550
                            CDK17; cyclin dependent kinase 17
                            3 of 14
                            603440
                                CDK18; cyclin dependent kinase 18
                                3 of 14
                                169190
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    Summary of Genetic Interactions
                                    Interaction Browsers
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    External Data
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    DroID - A comprehensive database of gene and protein interactions.
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    FlyBase
                                    External Links
                                    External Data
                                    Linkouts
                                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                    Class of Gene
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    3L
                                    Recombination map
                                    3-8
                                    Cytogenetic map
                                    63E3-63E5
                                    Sequence location
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    63E3-63E5
                                    Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    63E-63E
                                    (Lehner, 1996.7.23)
                                    63E-63E
                                    (determined by in situ hybridisation)
                                    (Sauer et al., 1996)
                                    Experimentally Determined Recombination Data
                                    Location

                                    3-8

                                    (FlyBase, 2016)

                                    3-7.1

                                    (Comeron et al., 2012)

                                    3-

                                    (Lehner, 1996.7.23)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (22)
                                    Genomic Clones (74)
                                    cDNA Clones (112)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                    Other clones
                                    Drosophila Genomics Resource Center cDNA clones

                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                    cDNA Clones, End Sequenced (ESTs)
                                    BDGP DGC clones
                                    Other clones
                                    RNAi and Array Information
                                    Linkouts
                                    DRSC - Results frm RNAi screens
                                    Antibody Information
                                    Laboratory Generated Antibodies
                                     
                                    Commercially Available Antibodies
                                     
                                    Cell Line Information
                                    Publicly Available Cell Lines
                                     
                                      Other Stable Cell Lines
                                       
                                        Other Comments

                                        When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in mitotic index is seen.

                                        (Bettencourt-Dias et al., 2004)

                                        Eip63E is required not only for metamorphosis, but also maternally and for embryonic and larval development.

                                        (Stowers et al., 2000)

                                        Characterisation of Eip63E.

                                        (Sauer et al., 1996)
                                        Relationship to Other Genes
                                        Source for database merge of

                                        Source for merge of: Eip63E Pftaire

                                        (Munroe et al., 1998.5.12)
                                        Additional comments
                                        Nomenclature History
                                        Source for database identify of

                                        Source for identity of: Eip63E CG10579

                                        (Li, 1999.11)
                                        Nomenclature comments
                                        Etymology
                                        Synonyms and Secondary IDs (9)
                                        Reported As
                                        Symbol Synonym
                                        CG10579
                                        (Ashraf et al., 2020, Neuert et al., 2017, Hosono et al., 2015, Christis and Munro, 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Morrison et al., 2000)
                                        Cdk14
                                        (Goins et al., 2024)
                                        EIP63E
                                        (Ritter and Beckstead, 2010)
                                        Eip63E
                                        (Goins et al., 2024, Ascencio et al., 2023, González et al., 2023, Deolankar et al., 2022, Havula et al., 2022, Liu et al., 2022, DeAngelis et al., 2021, Ashraf et al., 2020, Ojha and Tapadia, 2020, Port et al., 2020, Meltzer et al., 2019, Yildirim et al., 2019, Lavoy et al., 2018, Rousseaux et al., 2018, Neuert et al., 2017, Lefebvre et al., 2016, Ou et al., 2016, Aradska et al., 2015, Duff et al., 2015, Gene Disruption Project members, 2015-, Morgante et al., 2015, Van Bortle et al., 2015, Ashwal-Fluss et al., 2014, Sopko et al., 2014, Daneshvar et al., 2013, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Jungreis et al., 2011, Turner et al., 2011, Liu and Finley, 2010, Davidson et al., 2009, Bushati et al., 2008, FlyBase Curators, 2008-, Liu and Finley, 2008, Buszczak et al., 2007, Hueber et al., 2007, Jemc and Rebay, 2007, Liu and Finley, 2007, Godfrey et al., 2006, Stanyon et al., 2004)
                                        L63
                                        (Deng and Kerppola, 2013, Davidson et al., 2009, Rascle et al., 2003, Stowers et al., 2000, Rascle and Hogness, 1999, Munroe et al., 1998.5.12)
                                        PFTAIRE
                                        (Bjorklund et al., 2006)
                                        Pftaire
                                        (Xie et al., 2015)
                                        cdc2-63E
                                        (Richardson, 2005.2.11, Brumby et al., 2004)
                                        Name Synonyms
                                        Ecdysone-induced protein 63E
                                        (Hueber et al., 2007, Burnette et al., 2005)
                                        PFTAIRE
                                        (Morrison et al., 2000, Lehner, 1996.7.23, Sauer et al., 1996)
                                        Pftaire
                                        (Liu and Kipreos, 2000)
                                        Secondary FlyBase IDs
                                        • FBgn0016695
                                        • FBgn0024942
                                        Datasets (0)
                                        Study focus (0)
                                        Experimental Role
                                        Project
                                        Project Type
                                        Title
                                        Study result (0)
                                        Result
                                        Result Type
                                        Title
                                        External Crossreferences and Linkouts ( 127 )
                                        Sequence Crossreferences
                                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                        Other crossreferences
                                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                        FlyMine - An integrated database for Drosophila genomics
                                        InterPro - A database of protein families, domains and functional sites
                                        KEGG Genes - Molecular building blocks of life in the genomic space.
                                        MARRVEL_MODEL - MARRVEL (model organism gene)
                                        Linkouts
                                        BioGRID - A database of protein and genetic interactions.
                                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                        DroID - A comprehensive database of gene and protein interactions.
                                        DRSC - Results frm RNAi screens
                                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                        Flygut - An atlas of the Drosophila adult midgut
                                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                        MIST (protein-protein) - An integrated Molecular Interaction Database
                                        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                        References (131)