FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Eip63E81
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General Information
Symbol
Dmel\Eip63E81
Species
D. melanogaster
Name
FlyBase ID
FBal0089708
Feature type
allele
Associated gene
Dmel\Eip63E
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Munroe et al., 1998.5.12)
Progenitor genotype
Cytology
Description

48bp deletion that removes 16 codons from the Eip63E open reading frame. The deleted codons correspond to amino acids 213-228 of FBrf0090786.

(Munroe et al., 1998.5.12)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:3,598,066..3,598,113 [+]
Comment:

48bp deletion that removes 16 codons from the Eip63E open reading frame. The deleted codons correspond to amino acids 213-228 of FBrf0090786.

(Munroe et al., 1998.5.12)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eip63E81/Eip63EGN50 mutants display a major lethal phase during metamorphosis. Eip63E81/Eip63EGN50 mutants show metamorphosis defects including the failure of proper gas bubble translocation, failed head eversion, and the failure of proper leg elongation. In addition, pupae of Eip63E81/Eip63EGN50 mutants are small in weight and length. Eip63E81/Eip63EGN50 mutants exhibit delayed puparium formation.

      (Liu and Finley, 2010)

      The Eip63EGN50/Eip63E81 combination shows a heterogeneous lethal phase, with the majority of mutant animals dying during larval development and a small percentage living to pupation with an occasional adult escaper. Eip63E81/Df(3L)663 mutants have a bent leg phenotype.

      (Stowers et al., 2000)

      Lethality acts predominantly before the end of the third larval instar. Only a very small number pupariate.

      (Munroe et al., 1998.5.12)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Eip63E81/Eip63EGN50 is rescued by Eip63EB1.hs

      (Stowers et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      S. Paine-Saunders.

      (Munroe et al., 1998.5.12)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Eip63E81
      (Rousseaux et al., 2018, Liu and Finley, 2010)
      L6381
      (Stowers et al., 2000, Munroe et al., 1998.5.12)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)