Pak2, dPAK2, Ste20
Gene model reviewed during 5.42
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts tightly with GTP-bound but not GDP-bound Cdc42 and weakly with Rac1.
Autophosphorylated when activated by Cdc42.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mbt using the Feature Mapper tool.
In interphase neuroblasts, either weak cortical localization of mbt or a more pronounced basal staining was detected. Accumulation of apical mbt protein started at prophase, reached a peak during metaphase and decreased during anaphase. Thus, the apical enrichment of mbt is cell cycle dependent. This cell cycle dependent asymmetric accumulation of mbt was also observed in embryonic brain neuroblasts and thus seems to be present throughout neural development.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mbt in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Candidate stable intronic sequence RNA (sisRNA) identified within CDS of this gene.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells and/or aneuploidy, an increase in the proportion of G2/M phase cells and chromosome alignment defects are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
mbt could be part of a general mechanism regulating cell number in a variety of neuronal tissues.