Gene Group: P21-ACTIVATED KINASES

General Information

Name

P21-ACTIVATED KINASES

Species

D. melanogaster

Symbol

PAK

FlyBase ID

FBgg0000225

Date last reviewed

2015-03-25

Number of members

Description

PAK proteins are serine/threonine kinases characterised by an C-terminal STE20 kinase domain and an N-terminal p21-binding domain which binds RhoGTPases. PAKs are autoinhibited by homodimerization. PAKs are involved in the regulation of cytoskeleton organisation and other signaling cascades. (Adapted from FBrf0187582).

Notes on Group

Source Material

The P21-ACTIVATED KINASES Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Delpire, 2009, Mentzel and Raabe, 2005, Manning et al., 2002, Dan et al., 2001, and Morrison et al., 2000 .

Key Gene Ontology (GO) terms

Molecular Function

protein serine/threonine kinase activity

Biological Process

protein phosphorylation

Cellular Component

Enzymatic activity

Enzyme name (EC)

2.7.11.-

Related Gene Groups

Parent group(s)

STE20 KINASES