FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\S6kII
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General Information
Symbol
Dmel\S6kII
Species
D. melanogaster
Name
Ribosomal protein S6 kinase II
Annotation Symbol
CG17596
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262866
Gene Model Status
Current
Stock Availability
20 publicly available
Enzyme Name (EC)
Gene Summary
Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

RSK, ign, p90 ribosomal S6 kinase, rsk2, ignorant

Key Links
Genomic Location
Cytogenetic map
20C1-20C1
Sequence location
Recombination map
1-66
RefSeq locus
NC_004354 REGION:22529964..22536371
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (27 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables mitogen-activated protein kinase binding
inferred from physical interaction with FLYBASE:rl; FB:FBgn0003256
(Kim et al., 2006)
enables ribosomal protein S6 kinase activity
inferred from direct assay
(Kim et al., 2006)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables ATP binding
(InterPro Project Members, 2004-)
enables magnesium ion binding
inferred from electronic annotation with InterPro:IPR016239
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271
(InterPro Project Members, 2004-)
enables protein serine/threonine kinase activity
inferred from electronic annotation with InterPro:IPR000961, InterPro:IPR016239, InterPro:IPR017892
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR000961, InterPro:IPR017892
(InterPro Project Members, 2004-)
enables ribosomal protein S6 kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001219146
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity
(Wassarman et al., 1994)
Biological Process (15 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in associative learning
inferred from mutant phenotype
(Putz et al., 2004)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Kim et al., 2006)
involved_in imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Kim et al., 2006)
involved_in locomotor rhythm
inferred from mutant phenotype
(Akten et al., 2009)
involved_in negative regulation of compound eye cone cell fate specification
inferred from mutant phenotype
(Kim et al., 2006)
involved_in negative regulation of ERK1 and ERK2 cascade
inferred from direct assay
(Kim et al., 2006)
involved_in negative regulation of photoreceptor cell differentiation
inferred from mutant phenotype
(Kim et al., 2006)
involved_in negative regulation of pigment cell differentiation
inferred from mutant phenotype
(Kim et al., 2006)
involved_in negative regulation of protein import into nucleus
inferred from direct assay
(Kim et al., 2006)
involved_in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
inferred from mutant phenotype
(Kim et al., 2006)
involved_in neuromuscular junction development
inferred from mutant phenotype
(Fischer et al., 2009)
involved_in operant conditioning
inferred from mutant phenotype
(Putz et al., 2004)
involved_in regulation of neuromuscular junction development
inferred from mutant phenotype
(Beck et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in intracellular signal transduction
inferred from electronic annotation with InterPro:IPR016239
(InterPro Project Members, 2004-)
involved_in TORC1 signaling
inferred from biological aspect of ancestor with PANTHER:PTN000682103
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Kim et al., 2006)
located_in neuromuscular junction
inferred from direct assay
(Fischer et al., 2009)
located_in perikaryon
inferred from direct assay
(Beck et al., 2015)
located_in presynapse
inferred from direct assay
(Beck et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN008614612
(GO Reference Genome Project, 2011-)
is_active_in nucleoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000682103
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein serine/threonine kinase activity
Summaries
Gene Snapshot
Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
UNCLASSIFIED AGC KINASES -
This group comprises AGC kinases that do not classify under other groups in FlyBase.
Summary (Interactive Fly)

negatively regulates ERK-mediated developmental processes and gene expressions by blocking the nuclear localization of ERK - functions as a downstream effector and regulator of the MAP kinase pathway - involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning.

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\S6kII for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VR61)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
S6kII-RA
FBtr0077360
NM_078713
3777
911
S6kII-RB
FBtr0333715
NM_001272850
6055
911
Additional Transcript Data and Comments
Reported size (kB)

3.137 (longest cDNA)

(Wassarman et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
S6kII-PA
FBpp0077052
100.4
911
6.95
Q9VR61
NP_523437
AAF50945
S6kII-PB
FBpp0305864
100.4
911
6.95
Q9VR61
NP_001259779
AGB95617
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

911 aa isoforms: S6kII-PA, S6kII-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

910 (aa); 100 (kD predicted)

(Wassarman et al., 1994)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\S6kII using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head

Comment: displays circadian cycling

(Akten et al., 2009)
Additional Descriptive Data

S6kII transcripts were analyzed by qRT-PCR in adult head tissue. Levels of S6kII change in a diurnal manner with peak abundance occurring between Zeitgeber time 22 and 1.

(Akten et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Akten et al., 2009)
Additional Descriptive Data

S6kII protein levels were measured at six time points across the diurnal cycle and were found to be relatively constant across the cycle in adult head extracts.

(Akten et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Kim et al., 2006)
located_in neuromuscular junction
inferred from direct assay
(Fischer et al., 2009)
located_in perikaryon
inferred from direct assay
(Beck et al., 2015)
located_in presynapse
inferred from direct assay
(Beck et al., 2015)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\S6kII in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of S6kII
Transgenic constructs containing regulatory region of S6kII
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
semi-fertile
Other Phenotypes
Allele
abnormal learning
abnormal learning (with Df(1)R29)
abnormal learning (with S6kIIign-Δ24-3)
abnormal learning (with S6kIIign-Δ58-1)
abnormal learning | dominant
abnormal learning | male limited
abnormal locomotor rhythm
abnormal memory
abnormal memory | male limited
abnormal memory | recessive
abnormal neuroanatomy
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | third instar larval stage
abnormal neurophysiology
short lived
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4pnr-MD237
visible (with Df(1)R8A)
visible | recessive
Phenotype manifest in
Allele
chaeta | increased number, with Scer\GAL4pnr-MD237
cone cell
cone cell (with Df(1)R8A)
embryonic/larval neuromuscular junction
eye photoreceptor cell
eye photoreceptor cell, with Scer\GAL4hs.2sev
eye photoreceptor cell (with Df(1)R8A)
interommatidial bristle, with Scer\GAL4GMR.PF
mesonotum, with Scer\GAL4pnr-MD237
mitochondrion
NMJ bouton
NMJ bouton | increased number
NMJ bouton | larval stage
NMJ bouton | third instar larval stage
ommatidial precursor cluster
ommatidial precursor cluster (with Df(1)R8A)
ommatidium, with Scer\GAL4GMR.PF
pigment cell
pigment cell (with Df(1)R8A)
presynaptic active zone
retina, with Scer\GAL4GMR.PF
rhabdomere, with Scer\GAL4GMR.PF
wing vein, with Scer\GAL4Bx-MS1096
wing vein, with Scer\GAL4en-e16E
wing vein | ectopic
wing vein | ectopic (with Df(1)R8A)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (99)
Hsap\RPS6KA3
12 of 14
Yes
Yes
1  
Hsap\RPS6KA1
11 of 14
No
Yes
Hsap\RPS6KA2
11 of 14
No
Yes
Hsap\RPS6KA6
11 of 14
No
Yes
1  
Hsap\RPS6KA4
3 of 14
No
No
Hsap\RPS6KA5
3 of 14
No
No
Hsap\RPS6KB1
2 of 14
No
No
2  
Hsap\RPS6KB2
2 of 14
No
No
Hsap\AKT1
1 of 14
No
No
1  
Hsap\AKT2
1 of 14
No
No
5  
Hsap\AKT3
1 of 14
No
No
Hsap\BUB1B-PAK6
1 of 14
No
No
Hsap\C8orf44-SGK3
1 of 14
No
No
Hsap\CAMK4
1 of 14
No
No
Hsap\CDC7
1 of 14
No
No
Hsap\CDC42BPA
1 of 14
No
No
Hsap\CDK11A
1 of 14
No
No
Hsap\CDK11B
1 of 14
No
No
Hsap\CDK12
1 of 14
No
No
Hsap\CDK13
1 of 14
No
No
Hsap\CDK16
1 of 14
No
No
Hsap\CHEK1
1 of 14
No
No
1  
Hsap\CHUK
1 of 14
No
No
Hsap\CLK1
1 of 14
No
No
Hsap\DCLK1
1 of 14
No
No
Hsap\DMPK
1 of 14
No
No
5  
Hsap\FRK
1 of 14
No
No
Hsap\GRK1
1 of 14
No
No
Hsap\GRK2
1 of 14
No
No
Hsap\GRK3
1 of 14
No
No
1  
Hsap\GRK4
1 of 14
No
No
2  
Hsap\GRK5
1 of 14
No
No
Hsap\GRK6
1 of 14
No
No
Hsap\GRK7
1 of 14
No
No
Hsap\GSK3A
1 of 14
No
No
1  
Hsap\HCK
1 of 14
No
No
Hsap\HUNK
1 of 14
No
No
Hsap\IKBKB
1 of 14
No
No
1  
Hsap\IKBKE
1 of 14
No
No
1  
Hsap\LCK
1 of 14
No
No
Hsap\LYN
1 of 14
No
No
Hsap\MAP3K9
1 of 14
No
No
Hsap\MAP3K20
1 of 14
No
No
Hsap\MARK1
1 of 14
No
No
2  
Hsap\MARK2
1 of 14
No
No
3  
Hsap\MARK3
1 of 14
No
No
2  
Hsap\MARK4
1 of 14
No
No
4  
Hsap\MAST1
1 of 14
No
No
Hsap\MAST2
1 of 14
No
No
Hsap\NEK3
1 of 14
No
No
Hsap\NEK4
1 of 14
No
No
Hsap\NEK5
1 of 14
No
No
Hsap\NUAK1
1 of 14
No
No
2  
Hsap\PAK1
1 of 14
No
No
Hsap\PAK6
1 of 14
No
No
Hsap\PKN1
1 of 14
No
No
Hsap\PKN2
1 of 14
No
No
Hsap\PNCK
1 of 14
No
No
1  
Hsap\PRKACA
1 of 14
No
No
Hsap\PRKACB
1 of 14
No
No
Hsap\PRKACG
1 of 14
No
No
Hsap\PRKCA
1 of 14
No
No
Hsap\PRKCB
1 of 14
No
No
1  
Hsap\PRKCD
1 of 14
No
No
Hsap\PRKCE
1 of 14
No
No
Hsap\PRKCG
1 of 14
No
No
Hsap\PRKCH
1 of 14
No
No
Hsap\PRKCI
1 of 14
No
No
Hsap\PRKCQ
1 of 14
No
No
Hsap\PRKCZ
1 of 14
No
No
Hsap\PRKG1
1 of 14
No
No
1  
Hsap\PRKG2
1 of 14
No
No
1  
Hsap\PRKX
1 of 14
No
No
Hsap\PRKY
1 of 14
No
No
Hsap\PSKH1
1 of 14
No
No
Hsap\ROCK1
1 of 14
No
No
Hsap\ROCK2
1 of 14
No
No
1  
Hsap\RPS6KC1
1 of 14
No
No
Hsap\RSKR
1 of 14
No
No
Hsap\SBK1
1 of 14
No
No
2  
Hsap\SBK2
1 of 14
No
No
Hsap\SBK3
1 of 14
No
No
Hsap\SGK1
1 of 14
No
No
Hsap\SGK2
1 of 14
No
No
Hsap\SGK3
1 of 14
No
No
Hsap\SIK1B
1 of 14
No
No
Hsap\SIK1
1 of 14
No
No
1  
Hsap\SIK2
1 of 14
No
No
Hsap\SIK3
1 of 14
No
No
Hsap\SNX15
1 of 14
No
No
Hsap\STK32A
1 of 14
No
No
1  
Hsap\STK32B
1 of 14
No
No
Hsap\STK32C
1 of 14
No
No
1  
Hsap\STK36
1 of 14
No
No
1  
Hsap\STK38
1 of 14
No
No
1  
Hsap\STK38L
1 of 14
No
No
1  
Hsap\TAOK1
1 of 14
No
No
Hsap\TAOK2
1 of 14
No
No
4  
Hsap\TBK1
1 of 14
No
No
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (47)
Rnor\Rps6ka3
12 of 14
Yes
Yes
Rnor\Rps6ka2
11 of 14
No
Yes
Rnor\Rps6ka6
11 of 14
No
Yes
Rnor\Rps6ka1
10 of 14
No
Yes
Rnor\Rps6ka4
3 of 14
No
No
Rnor\Rps6ka5
2 of 14
No
No
Rnor\Rps6kb1
2 of 14
No
No
Rnor\Rps6kb2
2 of 14
No
No
Rnor\Akt1
1 of 14
No
No
Rnor\Akt2
1 of 14
No
No
Rnor\Akt3
1 of 14
No
No
Rnor\Chek1
1 of 14
No
No
Rnor\Chuk
1 of 14
No
No
Rnor\Dclk1
1 of 14
No
No
Rnor\Hunk
1 of 14
No
No
Rnor\Ikbkb
1 of 14
No
No
Rnor\Ikbke
1 of 14
No
No
Rnor\LOC300308
1 of 14
No
No
Rnor\LOC301165
1 of 14
No
No
Rnor\LOC100911229
1 of 14
No
No
Rnor\Mark2
1 of 14
No
No
Rnor\Mark3
1 of 14
No
No
Rnor\Mark4
1 of 14
No
No
Rnor\Mylk
1 of 14
No
No
Rnor\Pak1
1 of 14
No
No
Rnor\Pkn1
1 of 14
No
No
Rnor\Prkaca
1 of 14
No
No
Rnor\Prkacb
1 of 14
No
No
Rnor\Prkch
1 of 14
No
No
Rnor\Prkg2
1 of 14
No
No
Rnor\Pskh1
1 of 14
No
No
Rnor\RGD1562638
1 of 14
No
No
Rnor\Rock2
1 of 14
No
No
Rnor\Rps6kc1
1 of 14
No
No
Rnor\Sbk1
1 of 14
No
No
Rnor\Sbk2
1 of 14
No
No
Rnor\Sbk3
1 of 14
No
No
Rnor\Sgk1
1 of 14
No
No
Rnor\Sik2
1 of 14
No
No
Rnor\Snx15
1 of 14
No
No
Rnor\Stk32a
1 of 14
No
No
Rnor\Stk32b
1 of 14
No
No
Rnor\Stk32c
1 of 14
No
No
Rnor\Stk36
1 of 14
No
No
Rnor\Taok1
1 of 14
No
No
Rnor\Taok2
1 of 14
No
No
Rnor\Tbk1
1 of 14
No
No
Mus musculus (laboratory mouse) (58)
Mmus\Rps6ka3
12 of 14
Yes
Yes
Mmus\Rps6ka2
11 of 14
No
Yes
Mmus\Rps6ka6
11 of 14
No
Yes
Mmus\Rps6ka1
10 of 14
No
Yes
Mmus\Rps6ka5
3 of 14
No
No
Mmus\Rps6ka4
2 of 14
No
No
Mmus\Rps6kb1
2 of 14
No
No
Mmus\Rps6kb2
2 of 14
No
No
Mmus\4921509C19Rik
1 of 14
No
No
Mmus\Akt1
1 of 14
No
No
Mmus\Akt2
1 of 14
No
No
Mmus\Akt3
1 of 14
No
No
Mmus\Chek1
1 of 14
No
No
Mmus\Chuk
1 of 14
No
No
Mmus\Dclk1
1 of 14
No
No
Mmus\Dclk2
1 of 14
No
No
Mmus\Gm5890
1 of 14
No
Yes
Mmus\Gm5891
1 of 14
No
No
Mmus\Gm7168
1 of 14
No
No
Mmus\Gm7356
1 of 14
No
No
Mmus\Gm7358
1 of 14
No
No
Mmus\Gm10662
1 of 14
No
No
Mmus\Gm14147
1 of 14
No
No
Mmus\Gm14151
1 of 14
No
No
Mmus\Hunk
1 of 14
No
No
Mmus\Ikbkb
1 of 14
No
No
Mmus\Ikbke
1 of 14
No
No
Mmus\Mark2
1 of 14
No
No
Mmus\Mark3
1 of 14
No
No
Mmus\Mark4
1 of 14
No
No
Mmus\Nek3
1 of 14
No
No
Mmus\Pak1
1 of 14
No
No
Mmus\Prkaca
1 of 14
No
No
Mmus\Prkacb
1 of 14
No
No
Mmus\Prkch
1 of 14
No
No
Mmus\Prkg1
1 of 14
No
No
Mmus\Prkg2
1 of 14
No
No
Mmus\Pskh1
1 of 14
No
No
Mmus\Rock2
1 of 14
No
No
Mmus\Rps6kc1
1 of 14
No
No
Mmus\Rps6kl1
1 of 14
No
No
Mmus\Rskr
1 of 14
No
No
Mmus\Sbk1
1 of 14
No
No
Mmus\Sbk2
1 of 14
No
No
Mmus\Sbk3
1 of 14
No
No
Mmus\Sgk1
1 of 14
No
No
Mmus\Sik2
1 of 14
No
No
Mmus\Sik3
1 of 14
No
No
Mmus\Smok2a
1 of 14
No
No
Mmus\Smok2b
1 of 14
No
No
Mmus\Snx15
1 of 14
No
No
Mmus\Stk32a
1 of 14
No
No
Mmus\Stk32b
1 of 14
No
No
Mmus\Stk32c
1 of 14
No
No
Mmus\Stk36
1 of 14
No
No
Mmus\Taok1
1 of 14
No
No
Mmus\Taok2
1 of 14
No
No
Mmus\Tbk1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (61)
Xtro\rps6ka3
10 of 13
Yes
Yes
Xtro\rps6ka1
6 of 13
No
Yes
Xtro\rps6ka2
6 of 13
No
Yes
Xtro\rps6ka6
6 of 13
No
Yes
Xtro\camk1g
1 of 13
No
No
Xtro\cdk13
1 of 13
No
No
Xtro\cdk16
1 of 13
No
No
Xtro\chek2
1 of 13
No
No
Xtro\chuk
1 of 13
No
No
Xtro\dclk1
1 of 13
No
No
Xtro\gpha2
1 of 13
No
No
Xtro\grk1
1 of 13
No
No
Xtro\grk7
1 of 13
No
No
Xtro\gtpbp8
1 of 13
No
Yes
Xtro\hunk
1 of 13
No
Yes
Xtro\ikbkb
1 of 13
No
No
Xtro\itm2a
1 of 13
No
No
Xtro\LOC100145764
1 of 13
No
No
Xtro\LOC100485259
1 of 13
No
No
Xtro\LOC100498055
1 of 13
No
No
Xtro\LOC101732362
1 of 13
No
No
Xtro\LOC101732839
1 of 13
No
No
Xtro\LOC116406512
1 of 13
No
No
Xtro\map3k20
1 of 13
No
No
Xtro\mapk7
1 of 13
No
No
Xtro\mark1
1 of 13
No
No
Xtro\mark2
1 of 13
No
No
Xtro\mark4
1 of 13
No
No
Xtro\neu4
1 of 13
No
No
Xtro\nuak2
1 of 13
No
No
Xtro\pkn2
1 of 13
No
No
Xtro\pkn3
1 of 13
No
No
Xtro\plk4
1 of 13
No
No
Xtro\prkaca
1 of 13
No
No
Xtro\prkcb
1 of 13
No
No
Xtro\prkcd
1 of 13
No
No
Xtro\prkcq
1 of 13
No
No
Xtro\prkg1
1 of 13
No
No
Xtro\prkg2
1 of 13
No
No
Xtro\prkx
1 of 13
No
No
Xtro\pskh1
1 of 13
No
No
Xtro\rab37
1 of 13
No
No
Xtro\rock1
1 of 13
No
No
Xtro\rps6ka4
1 of 13
No
No
Xtro\rps6ka5
1 of 13
No
No
Xtro\rps6kb1
1 of 13
No
No
Xtro\rskr
1 of 13
No
No
Xtro\sbk1l
1 of 13
No
No
Xtro\sbk2
1 of 13
No
No
Xtro\sgk1
1 of 13
No
No
Xtro\sgk3
1 of 13
No
No
Xtro\sik3
1 of 13
No
Yes
Xtro\slc35d1
1 of 13
No
No
Xtro\snrk
1 of 13
No
No
Xtro\speg
1 of 13
No
No
Xtro\stk32c
1 of 13
No
No
Xtro\taok1
1 of 13
No
No
Xtro\taok2
1 of 13
No
No
Xtro\tbk1
1 of 13
No
No
Xtro\tmem52
1 of 13
No
No
Xtro\ulk3
1 of 13
No
No
Danio rerio (Zebrafish) (62)
Drer\rps6ka2
11 of 14
Yes
Yes
Drer\rps6ka3a
11 of 14
Yes
Yes
Drer\rps6ka3b
11 of 14
Yes
Yes
Drer\rps6kal
10 of 14
No
Yes
Drer\rps6ka1
9 of 14
No
Yes
Drer\rps6ka4
3 of 14
No
No
Drer\rps6ka5
3 of 14
No
No
Drer\rps6kb1b
2 of 14
No
No
Drer\ahnak
1 of 14
No
Yes
Drer\akt2
1 of 14
No
No
Drer\akt3a
1 of 14
No
No
Drer\akt3b
1 of 14
No
No
Drer\aurkb
1 of 14
No
No
Drer\bsk146
1 of 14
No
No
Drer\camk1db
1 of 14
No
No
Drer\camk4
1 of 14
No
No
Drer\cdc42bpaa
1 of 14
No
No
Drer\chek2
1 of 14
No
No
Drer\chuk
1 of 14
No
No
Drer\ikbkb
1 of 14
No
No
Drer\ikbke
1 of 14
No
No
Drer\LOC100536197
1 of 14
No
No
Drer\LOC101885029
1 of 14
No
No
Drer\mak
1 of 14
No
No
Drer\mark2a
1 of 14
No
No
Drer\mark2b
1 of 14
No
No
Drer\mark3a
1 of 14
No
No
Drer\mark3b
1 of 14
No
No
Drer\mark4b
1 of 14
No
No
Drer\pak2b
1 of 14
No
No
Drer\pak6b
1 of 14
No
No
Drer\prkacaa
1 of 14
No
No
Drer\prkacab
1 of 14
No
No
Drer\prkacba
1 of 14
No
No
Drer\prkacbb
1 of 14
No
No
Drer\prkcda
1 of 14
No
No
Drer\prkg1a
1 of 14
No
No
Drer\prkg1b
1 of 14
No
No
Drer\prkg2
1 of 14
No
No
Drer\prkx
1 of 14
No
No
Drer\pskh1
1 of 14
No
No
Drer\rock1
1 of 14
No
No
Drer\rps6kb1a
1 of 14
No
No
Drer\rskra
1 of 14
No
No
Drer\rskrb
1 of 14
No
No
Drer\sbk1
1 of 14
No
No
Drer\sbk3
1 of 14
No
No
Drer\sgk1
1 of 14
No
No
Drer\sgk2b
1 of 14
No
No
Drer\sgk3
1 of 14
No
No
Drer\si:ch73-60h1.1
1 of 14
No
No
Drer\si:ch211-171h4.3
1 of 14
No
No
Drer\si:dkey-8e10.3
1 of 14
No
No
Drer\sik1
1 of 14
No
No
Drer\sik2a
1 of 14
No
No
Drer\sik2b
1 of 14
No
No
Drer\stk32a
1 of 14
No
No
Drer\stk39
1 of 14
No
No
Drer\taok1a
1 of 14
No
No
Drer\taok2b
1 of 14
No
No
Drer\tbk1
1 of 14
No
No
Drer\unm_sa1261
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (47)
Cele\rskn-1
11 of 14
Yes
Yes
Cele\R04A9.7
2 of 14
No
No
Cele\rskn-2
2 of 14
No
No
Cele\rsks-1
2 of 14
No
No
Cele\aak-1
1 of 14
No
No
Cele\akt-1
1 of 14
No
No
Cele\akt-2
1 of 14
No
No
Cele\C01C4.3
1 of 14
No
No
Cele\cdc-7
1 of 14
No
No
Cele\cdk-9
1 of 14
No
No
Cele\cdk-11.1
1 of 14
No
No
Cele\cdk-11.2
1 of 14
No
No
Cele\cdk-12
1 of 14
No
No
Cele\chk-1
1 of 14
No
No
Cele\chk-2
1 of 14
No
No
Cele\egl-4
1 of 14
No
No
Cele\F28C10.3
1 of 14
No
No
Cele\F31E3.2
1 of 14
No
No
Cele\F32D8.1
1 of 14
No
No
Cele\frk-1
1 of 14
No
No
Cele\grk-1
1 of 14
No
No
Cele\grk-2
1 of 14
No
No
Cele\kin-1
1 of 14
No
No
Cele\kin-4
1 of 14
No
No
Cele\kin-29
1 of 14
No
No
Cele\kin-33
1 of 14
No
No
Cele\M03C11.1
1 of 14
No
No
Cele\mrck-1
1 of 14
No
No
Cele\mtk-1
1 of 14
No
No
Cele\nekl-3
1 of 14
No
No
Cele\par-1
1 of 14
No
No
Cele\pkc-1
1 of 14
No
No
Cele\pkc-2
1 of 14
No
No
Cele\pkc-3
1 of 14
No
No
Cele\pkg-2
1 of 14
No
No
Cele\pmk-2
1 of 14
No
No
Cele\sad-1
1 of 14
No
No
Cele\sax-1
1 of 14
No
No
Cele\sgk-1
1 of 14
No
No
Cele\T08D2.7
1 of 14
No
No
Cele\tpa-1
1 of 14
No
No
Cele\txt-2
1 of 14
No
No
Cele\unc-22
1 of 14
No
No
Cele\unc-43
1 of 14
No
No
Cele\unc-82
1 of 14
No
No
Cele\Y43D4A.6
1 of 14
No
No
Cele\ZK524.4
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (44)
Agam\AgaP_AGAP003040
11 of 12
Yes
Yes
Agam\AgaP_AGAP006094
3 of 12
No
No
Agam\AgaP_AGAP007333
2 of 12
No
No
Agam\AgaP_AGAP000028
1 of 12
No
No
Agam\AgaP_AGAP000234
1 of 12
No
No
Agam\AgaP_AGAP000418
1 of 12
No
No
Agam\AgaP_AGAP000477
1 of 12
No
No
Agam\AgaP_AGAP001384
1 of 12
No
No
Agam\AgaP_AGAP001633
1 of 12
No
No
Agam\AgaP_AGAP001752
1 of 12
No
No
Agam\AgaP_AGAP001909
1 of 12
No
No
Agam\AgaP_AGAP002110
1 of 12
No
No
Agam\AgaP_AGAP002161
1 of 12
No
No
Agam\AgaP_AGAP002748
1 of 12
No
No
Agam\AgaP_AGAP003005
1 of 12
No
No
Agam\AgaP_AGAP003174
1 of 12
No
No
Agam\AgaP_AGAP004117
1 of 12
No
No
Agam\AgaP_AGAP005306
1 of 12
No
No
Agam\AgaP_AGAP005521
1 of 12
No
No
Agam\AgaP_AGAP006044
1 of 12
No
No
Agam\AgaP_AGAP006411
1 of 12
No
No
Agam\AgaP_AGAP007587
1 of 12
No
No
Agam\AgaP_AGAP008038
1 of 12
No
Yes
Agam\AgaP_AGAP008039
1 of 12
No
No
Agam\AgaP_AGAP008118
1 of 12
No
No
Agam\AgaP_AGAP008585
1 of 12
No
No
Agam\AgaP_AGAP008863
1 of 12
No
No
Agam\AgaP_AGAP009565
1 of 12
No
No
Agam\AgaP_AGAP009798
1 of 12
No
No
Agam\AgaP_AGAP009934
1 of 12
No
No
Agam\AgaP_AGAP010327
1 of 12
No
No
Agam\AgaP_AGAP010874
1 of 12
No
No
Agam\AgaP_AGAP011030
1 of 12
No
No
Agam\AgaP_AGAP011055
1 of 12
No
No
Agam\AgaP_AGAP011840
1 of 12
No
No
Agam\AgaP_AGAP011890
1 of 12
No
No
Agam\AgaP_AGAP011988
1 of 12
No
No
Agam\AgaP_AGAP012025
1 of 12
No
No
Agam\AgaP_AGAP012026
1 of 12
No
No
Agam\AgaP_AGAP012064
1 of 12
No
No
Agam\AgaP_AGAP012244
1 of 12
No
No
Agam\AgaP_AGAP012252
1 of 12
No
No
Agam\AgaP_AGAP013439
1 of 12
No
No
Agam\IKK1
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (102)
Atha\PK1
4 of 13
Yes
No
Atha\S6K2
4 of 13
Yes
No
Atha\AGC1.5
1 of 13
No
No
Atha\AGC1.7
1 of 13
No
No
Atha\AGC2-1
1 of 13
No
Yes
Atha\AT1G03740
1 of 13
No
No
Atha\AT1G03920
1 of 13
No
No
Atha\AT1G09600
1 of 13
No
No
Atha\AT1G18160
1 of 13
No
No
Atha\AT1G30640
1 of 13
No
No
Atha\AT1G33770
1 of 13
No
No
Atha\AT1G45160
1 of 13
No
No
Atha\AT1G48490
1 of 13
No
No
Atha\AT1G53050
1 of 13
No
No
Atha\AT1G54610
1 of 13
No
No
Atha\AT1G57700
1 of 13
No
No
Atha\AT1G67580
1 of 13
No
No
Atha\AT1G67890
1 of 13
No
No
Atha\AT1G71530
1 of 13
No
No
Atha\AT1G73660
1 of 13
No
No
Atha\AT1G74330
1 of 13
No
No
Atha\AT2G20470
1 of 13
No
No
Atha\AT2G36350
1 of 13
No
Yes
Atha\AT2G44830
1 of 13
No
No
Atha\AT3G01085
1 of 13
No
No
Atha\AT3G05050
1 of 13
No
No
Atha\AT3G17850
1 of 13
No
No
Atha\AT3G23310
1 of 13
No
No
Atha\AT3G44610
1 of 13
No
No
Atha\AT3G46140
1 of 13
No
Yes
Atha\AT3G46930
1 of 13
No
No
Atha\AT4G10010
1 of 13
No
No
Atha\AT4G13000
1 of 13
No
Yes
Atha\AT4G14350
1 of 13
No
No
Atha\AT4G19110
1 of 13
No
No
Atha\AT4G24480
1 of 13
No
No
Atha\AT4G31170
1 of 13
No
No
Atha\AT4G32250
1 of 13
No
Yes
Atha\AT4G33080
1 of 13
No
No
Atha\AT5G03640
1 of 13
No
Yes
Atha\AT5G09890
1 of 13
No
No
Atha\AT5G21222
1 of 13
No
No
Atha\AT5G40030
1 of 13
No
No
Atha\AT5G44290
1 of 13
No
No
Atha\ATMRK1
1 of 13
No
No
Atha\ATPK7
1 of 13
No
No
Atha\ATSK12
1 of 13
No
No
Atha\CAK1AT
1 of 13
No
Yes
Atha\CDKC2
1 of 13
No
No
Atha\CDKC;1
1 of 13
No
No
Atha\CIPK1
1 of 13
No
No
Atha\CIPK3
1 of 13
No
No
Atha\CIPK5
1 of 13
No
No
Atha\CIPK9
1 of 13
No
No
Atha\CIPK13
1 of 13
No
No
Atha\CIPK15
1 of 13
No
No
Atha\CIPK20
1 of 13
No
No
Atha\CIPK21
1 of 13
No
No
Atha\CIPK23
1 of 13
No
No
Atha\CTR1
1 of 13
No
No
Atha\D6PK
1 of 13
No
No
Atha\D6PKL1
1 of 13
No
No
Atha\D6PKL2
1 of 13
No
No
Atha\HT1
1 of 13
No
No
Atha\IBS1
1 of 13
No
No
Atha\IRE
1 of 13
No
No
Atha\KEG
1 of 13
No
Yes
Atha\KIPK
1 of 13
No
No
Atha\MAPKKK5
1 of 13
No
No
Atha\MAPKKK20
1 of 13
No
Yes
Atha\MEKK1
1 of 13
No
No
Atha\MKK7
1 of 13
No
No
Atha\MKK9
1 of 13
No
No
Atha\MKK10
1 of 13
No
No
Atha\MPK7
1 of 13
No
No
Atha\NEK1
1 of 13
No
No
Atha\NEK6
1 of 13
No
No
Atha\NP1
1 of 13
No
No
Atha\NP2
1 of 13
No
No
Atha\PDK1
1 of 13
No
No
Atha\PHOT1
1 of 13
No
Yes
Atha\PHOT2
1 of 13
No
Yes
6  
Atha\PID2
1 of 13
No
No
Atha\PID
1 of 13
No
No
Atha\RSH3
1 of 13
No
No
Atha\SIP1
1 of 13
No
No
Atha\SIP3
1 of 13
No
No
Atha\SNRK2.1
1 of 13
No
No
Atha\SNRK2.5
1 of 13
No
No
Atha\SNRK2.7
1 of 13
No
No
Atha\SNRK2.9
1 of 13
No
No
Atha\SNRK2.10
1 of 13
No
No
Atha\STY8
1 of 13
No
No
Atha\STY17
1 of 13
No
No
Atha\STY46
1 of 13
No
No
Atha\UCN
1 of 13
No
Yes
Atha\UCNL
1 of 13
No
Yes
Atha\WAG1
1 of 13
No
No
Atha\WAG2
1 of 13
No
No
Atha\WNK5
1 of 13
No
No
Atha\WRKY19
1 of 13
No
No
Atha\YDA
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (23)
Scer\FPK1
2 of 13
Yes
Yes
Scer\KIN82
2 of 13
Yes
Yes
Scer\SCH9
2 of 13
Yes
No
Scer\YPK1
2 of 13
Yes
No
Scer\YPK2
2 of 13
Yes
No
Scer\ATG1
1 of 13
No
No
Scer\BCK1
1 of 13
No
No
Scer\CBK1
1 of 13
No
No
Scer\CDC7
1 of 13
No
No
Scer\CLA4
1 of 13
No
No
Scer\KIN1
1 of 13
No
No
Scer\KIN2
1 of 13
No
No
Scer\KIN3
1 of 13
No
No
Scer\PKH2
1 of 13
No
No
Scer\RIM15
1 of 13
No
No
Scer\SGV1
1 of 13
No
No
Scer\SMK1
1 of 13
No
No
Scer\SNF1
1 of 13
No
No
Scer\TPK1
1 of 13
No
No
Scer\TPK2
1 of 13
No
No
Scer\TPK3
1 of 13
No
No
Scer\YPK3
1 of 13
No
No
Scer\YPL150W
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (11)
Spom\psk1
3 of 12
Yes
No
Spom\cds1
1 of 12
No
No
Spom\cek1
1 of 12
No
No
Spom\chk1
1 of 12
No
No
Spom\cmk1
1 of 12
No
No
Spom\gad8
1 of 12
No
No
Spom\ppk14
1 of 12
No
Yes
Spom\ppk16
1 of 12
No
Yes
Spom\ppk22
1 of 12
No
Yes
Spom\sck1
1 of 12
No
No
Spom\ssp2
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:S6kII. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (48)
JIL-1
5 of 13
S6k
5 of 13
Akt
1 of 13
aPKC
1 of 13
bt
1 of 13
CaMKI
1 of 13
CaMKII
1 of 13
Cdc7
1 of 13
Cdk12
1 of 13
CG4839
1 of 13
CG4945
1 of 13
CG5790
1 of 13
CG12069
1 of 13
CG32944
1 of 13
for
1 of 13
Gprk1
1 of 13
Gprk2
1 of 13
grp
1 of 13
IKKβ
1 of 13
IKKε
1 of 13
inaC
1 of 13
KP78a
1 of 13
KP78b
1 of 13
lok
1 of 13
mbt
1 of 13
Mekk1
1 of 13
meng
1 of 13
Pak
1 of 13
par-1
1 of 13
Pitslre
1 of 13
Pka-C1
1 of 13
Pka-C2
1 of 13
Pkc53E
1 of 13
Pkc98E
1 of 13
Pkcδ
1 of 13
Pkg21D
1 of 13
Pkn
1 of 13
png
1 of 13
Rps6kc1
1 of 13
S6KL
1 of 13
SAK
1 of 13
sff
1 of 13
sgg
1 of 13
Sik2
1 of 13
Sik3
1 of 13
Snrk
1 of 13
sti
1 of 13
trc
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
S6kIIign-Δ58-1
model of  Coffin-Lowry syndrome
CEA
(Beck et al., 2015)
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RPS6KA3; ribosomal protein S6 kinase A3
12 of 14
RIBOSOMAL PROTEIN S6 KINASE A3; RPS6KA3
 
RPS6KA1; ribosomal protein S6 kinase A1
11 of 14
601684
      RPS6KA2; ribosomal protein S6 kinase A2
      11 of 14
      601685
          RPS6KA6; ribosomal protein S6 kinase A6
          11 of 14
          300303
               
              RPS6KA4; ribosomal protein S6 kinase A4
              3 of 14
              603606
                  RPS6KA5; ribosomal protein S6 kinase A5
                  3 of 14
                  603607
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Interactions
                      Summary of Physical Interactions
                      Interaction Browsers
                      View in FlyBase Interactions Browser   View in MIST tool (external link)
                      Please see the Physical Interaction reports below for full details
                      protein-protein
                      Physical Interaction
                      Assay
                      References
                      S6kII - 14-3-3ε
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - AGO2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Acc
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Acn
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Act42A
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Aldh
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Ankle2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Arc1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Bap111
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Vinayagam et al., 2013)
                      S6kII - Bap55
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Brr2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CCT1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CCT2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CCT5
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG10333
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG11417
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG11583
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG13096
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG13097
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG15019
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG1513
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG1542
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG15784
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG1703
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG17593
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG2691
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG30122
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG32409
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG3335
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG3817
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG42354
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG4806
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG5033
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG5645
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG5787
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG7065
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG7564
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CG9776
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Caf1-55
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Cdc5
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CkIIα
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - CkIIβ
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Akten et al., 2009)
                      S6kII - Claspin
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Cpsf5
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Cpsf6
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Ctf4
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Droj2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Fib
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Fmr1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Gnf1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Gp150
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - HDAC1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Hrb98DE
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Hsc70-3
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Imp
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Ipo9
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Isha
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Kap-α3
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Mi-2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Nipped-B
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Noc2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Non3
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Nop60B
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Nopp140
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Nph
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Ns1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Nup358
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - PH4αEFB
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Pnn
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Polr1A
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Polr1B
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Pp2B-14D
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Prp19
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Prp8
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RAF2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Rack1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Rbcn-3A
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Ref1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RhoGAP18B
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Rip11
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Rm62
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL10
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL10Ab
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL13
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL13A
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL14
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL15
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL17
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL18
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL18A
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL19
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL23A
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL26
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL27
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL28
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL31
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL35
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL35A
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL36
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL4
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL6
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL7
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL7A
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL8
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpL9
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpLP1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS11
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS14a
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS15
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS15Aa
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS16
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS17
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS23
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS25
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS4
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS5a
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS6
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS7
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - RpS9
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Rtf1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - SF1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - SF2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - ScsβA
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Sec63
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Sf3b2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Spt5
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - SrpRα
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Ssb-c31a
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Taf3
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - TfIIFα
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - TfIIFβ
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Tsc1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - UQCR-C2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - ZC3H18
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - Zn72D
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - alt
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - bif
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - brm
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - bsf
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - cindr
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - cora
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF3a
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF3b
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF3c
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF3d1
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF3e
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF3h
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF3i
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF3k
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF3m
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eIF4A
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - eRF3
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - gig
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - hts
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - kis
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - kst
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - kuk
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - l(2)09851
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - larp
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - lds
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - mRpL12
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - mahj
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - mask
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - mor
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - msn
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - ncd
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - ncm
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - nonA
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - peng
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - pic
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - pont
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - ppan
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - pths
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - pzg
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - qkr58E-3
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - rept
                      anti tag coimmunoprecipitation, anti tag western blot
                      (Vinayagam et al., 2016)
                      S6kII - row
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - rump
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - rush
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - scaf6
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - sgg
                      enzymatic study, western blot, anti tag coimmunoprecipitation, anti tag western blot
                      (Beck et al., 2018)
                      S6kII - sip2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - sle
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - smid
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - spoon
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - sqd
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - ssx
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - vig
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - vig2
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - yps
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - zda
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - α-Spec
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - βTub60D
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      S6kII - βTub97EF
                      anti tag coimmunoprecipitation, Identification by mass spectrometry
                      (Vinayagam et al., 2016)
                      Summary of Genetic Interactions
                      Interaction Browsers
                      View in FlyBase Interactions Browser   View in MIST tool (external link)
                      Please look at the allele data for full details of the genetic interactions
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      S6kII
                      suppressible
                      CkIIα
                      (Akten et al., 2009)
                      S6kII
                      suppressible
                      CkIIβ
                      (Akten et al., 2009)
                      S6kII
                      enhanceable
                      Dsor1
                      (Kim et al., 2006)
                      S6kII
                      suppressible
                      Pdk1
                      (Rintelen et al., 2001)
                      S6kII
                      enhanceable
                      Raf
                      (Kim et al., 2006)
                      S6kII
                      enhanceable
                      Ras85D
                      (Kim et al., 2006)
                      S6kII
                      enhanceable
                      rl
                      (Kim et al., 2006)
                      S6kII
                      suppressible
                      rl
                      (Fischer et al., 2009)
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      Raf
                      suppressible
                      S6kII
                      (Kim et al., 2006)
                      Raf
                      enhanceable
                      S6kII
                      (Kim et al., 2006)
                      Ras85D
                      suppressible
                      S6kII
                      (Kim et al., 2006)
                      Ras85D
                      enhanceable
                      S6kII
                      (Kim et al., 2006)
                      sev
                      suppressible
                      S6kII
                      (Kim et al., 2006)
                      External Data
                      Linkouts
                      DroID - A comprehensive database of gene and protein interactions.
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Pathways
                      Signaling Pathways (FlyBase)
                      Metabolic Pathways
                      FlyBase
                      External Links
                      External Data
                      Linkouts
                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                      Class of Gene
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      X
                      Recombination map
                      1-66
                      Cytogenetic map
                      20C1-20C1
                      Sequence location
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      20C1-20C1
                      Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      20-20
                      (Wassarman, 1994.10.14)
                      20-20
                      (determined by in situ hybridisation)
                      (Wassarman et al., 1994)
                      Experimentally Determined Recombination Data
                      Location

                      1-66

                      (FlyBase, 2016)

                      1-66.3

                      (Comeron et al., 2012)
                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (20)
                      Genomic Clones (12)
                       

                      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                      cDNA Clones (29)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequenced
                      BDGP DGC clones
                      Other clones
                        Drosophila Genomics Resource Center cDNA clones

                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                        cDNA Clones, End Sequenced (ESTs)
                        BDGP DGC clones
                        Other clones
                        RNAi and Array Information
                        Linkouts
                        Antibody Information
                        Laboratory Generated Antibodies
                         

                        polyclonal

                        (Fischer et al., 2009)
                        Commercially Available Antibodies
                         
                        Cell Line Information
                        Publicly Available Cell Lines
                         
                          Other Stable Cell Lines
                           
                            Other Comments

                            S6kII negatively regulates bouton number at the larval neuromuscular junction.

                            (Fischer et al., 2009)

                            Homologue of human RSK2 corresponding to Coffin-Lowry syndrome gene.

                            (Olson et al., 2007)

                            The rl-binding activity of S6kII, but not the phosphotransferase activity, is essential for the in vivo function of S6kII in eye and wing development. S6kII regulates rl activity by acting as a cytoplasmic anchor.

                            (Kim et al., 2006)

                            When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G2/M phase cells is seen.

                            (Bettencourt-Dias et al., 2004)

                            One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

                            (Inlow and Restifo, 2004)

                            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                            (Kiger et al., 2003)

                            A S6kII cDNA has been cloned and sequenced.

                            (Wassarman et al., 1994)
                            Relationship to Other Genes
                            Source for database merge of

                            Source for merge of: S6kII rsk2

                            (Restifo, 2011.1.20)
                            Additional comments
                            Nomenclature History
                            Source for database identify of
                            Nomenclature comments
                            Etymology
                            Synonyms and Secondary IDs (18)
                            Reported As
                            Symbol Synonym
                            CG17596
                            (Lee et al., 2021, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Sun et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Putz et al., 2004, Morrison et al., 2000)
                            D-RSK
                            (Fischer and Raabe, 2018)
                            RSK
                            (Mariano et al., 2020, Beck et al., 2018, Beck et al., 2015, Akten et al., 2009, Bjorklund et al., 2006, Kim et al., 2006, Brembs, 2003, Morrison et al., 2000, Johansen et al., 1999, Wassarman, 1994.10.14)
                            Rsk
                            S6KII
                            (Wippich et al., 2023, Zhang et al., 2014, Zhu, 2013, Tangredi et al., 2012, Slack et al., 2010, Akten et al., 2009, Neuser et al., 2008, Putz et al., 2004, Wassarman et al., 1994)
                            S6kII
                            (Deng et al., 2025, Loreto et al., 2024, Bilder et al., 2021, Lee et al., 2021, Wang et al., 2020, Hegazi et al., 2019, Mast and DiPrimio, 2019.3.12, Transgenic RNAi Project members, 2017-, Yang and Veraksa, 2017, Dobson et al., 2016, Schwartz et al., 2016, Vinayagam et al., 2016, Cugusi et al., 2015, Sopko et al., 2014, Vinayagam et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Korcsmáros et al., 2011, Restifo, 2011.1.20, Sun et al., 2010, Akten et al., 2009)
                            dRSK
                            (Pospisilik et al., 2010, Rintelen et al., 2001)
                            dRsk
                            (Okray and Hassan, 2013)
                            ign
                            (Kuntz et al., 2017, Neuser et al., 2008, Putz et al., 2004, Brembs, 2003)
                            rsk
                            (Scholz et al., 2019, Beck et al., 2018, Fischer et al., 2009)
                            rsk2
                            (Restifo, 2011.1.20, Olson et al., 2007)
                            Name Synonyms
                            RPS6-protein kinase-II
                            Ribosomal protein S6 kinase II
                            Ribosomal-S6-kinase
                            S6 kinase II
                            (Neuser et al., 2008)
                            ignorant
                            (Neuser et al., 2008, Putz et al., 2004, Brembs, 2003)
                            p90 ribosomal S6 kinase
                            (Akten et al., 2009, Kim et al., 2006, Brembs, 2003)
                            ribosomal-S6-kinase
                            (Pospisilik et al., 2010)
                            Secondary FlyBase IDs
                            • FBgn0011285
                            • FBgn0086241
                            Datasets (0)
                            Study focus (0)
                            Experimental Role
                            Project
                            Project Type
                            Title
                            Study result (0)
                            Result
                            Result Type
                            Title
                            External Crossreferences and Linkouts ( 52 )
                            Sequence Crossreferences
                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                            Other crossreferences
                            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                            InterPro - A database of protein families, domains and functional sites
                            KEGG Genes - Molecular building blocks of life in the genomic space.
                            MARRVEL_MODEL - MARRVEL (model organism gene)
                            Linkouts
                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                            DroID - A comprehensive database of gene and protein interactions.
                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                            MIST (genetic) - An integrated Molecular Interaction Database
                            MIST (protein-protein) - An integrated Molecular Interaction Database
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                            References (93)