FlyBase Allele Report: Dmel\S6kII[ign-Δ24-3]

General Information

Symbol

Dmel\S6kII^ign-Δ24-3

Species

D. melanogaster

Name

FlyBase ID

FBal0215318

Feature type

allele

Associated gene

Dmel\S6kII

Associated Insertion(s)

P{?lacW}S6kII^ign-Δ24-3

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Putz et al., 2004)

Progenitor genotype

P{lacW}S6kII^ign-P1

(Putz et al., 2004)

Associated Insertion(s)

P{?lacW}S6kII^ign-Δ24-3

Cytology

Description

Imprecise excision of the P{lacW} element, resulting in loss of 1322bp of genomic sequence in the 5' region of the S6kII gene, removing part of the first exon. Part of the P{lacW} element is retained.

(Putz et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning (with Df(1)R29)

(Putz et al., 2004)

abnormal learning (with S6kII^ign-Δ58-1)

(Putz et al., 2004)

abnormal learning | dominant

(Putz et al., 2004)

abnormal memory | recessive

(Putz et al., 2004)

abnormal neuroanatomy | third instar larval stage

(Fischer et al., 2009)

Phenotype Manifest In

NMJ bouton | third instar larval stage

(Fischer et al., 2009)

Detailed Description

Statement

Reference

Absolute bouton number at the neuromuscular junction (NMJ) at segment A3 in muscle 6/7 is significantly higher in S6kII^ign-Δ24-3 third instar larvae compared to controls. The bouton number per muscle area is also significantly higher in the mutant larvae compared to controls. Both type 1s and type 1b boutons show an increase in absolute bouton number at the NMJ and an increase in bouton number per muscle area.

(Fischer et al., 2009)

S6kII^ign-Δ24-3 homozygous and heterozygous flies show reduced operant conditioning in terms of heat box learning in both genders. S6kII^ign-Δ24-3/Df(1)R29 and S6kII^ign-Δ24-3/S6kII^ign-Δ58-1 transheterozygotes also show this phenotype. Thermo-reception is not affected in any of these genotypes.

S6kII^ign-Δ24-3 homozygous flies show an impairment in pavlovian olfactory discrimination learning, with a 40% lower performance index in 3 min memory. The performance of S6kII^ign-Δ24-3/+ flies is not significantly different from wild type. S6kII^ign-Δ58-1/Y; S6kII^t6.5/+ flies perform as well as wild-type flies in pavlovian oflactory conditioning memory tests.

(Putz et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Df(1)ign^Δ24-3

(Putz et al., 2004)

Df(1)ign^Δ24/3

(Fischer et al., 2009)

S6kII^ign-Δ24-3

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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