FlyBase Gene Report: Dmel\Pitslre

General Information

Symbol

Dmel\Pitslre

Species

D. melanogaster

Name

Pitslre

Annotation Symbol

CG4268

Feature Type

protein_coding_gene

FlyBase ID

FBgn0016696

Gene Model Status

Current

Stock Availability

20 publicly available

Enzyme Name (EC)

cyclin-dependent kinase (2.7.11.22)

Gene Summary

Acts as a negative regulator of the normal cell cycle progression. May function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase (By similarity). (UniProt, Q9VPC0)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

cdk11, PitsIre, group 3

Key Links

Genomic Location

Cytogenetic map

77E6-77E6

Sequence location

3L:20,771,528..20,776,931 [+]

Recombination map

3-47

RefSeq locus

NT_037436 REGION:20771528..20776931

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR045267

(InterPro Project Members, 2004-)

enables cyclin-dependent protein serine/threonine kinase activity

inferred from sequence or structural similarity with SGD:S000001622

(Gene Ontology Curators, 2002-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from electronic annotation with InterPro:IPR045267

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:Q00534

(Sauer et al., 1996)

inferred from sequence or structural similarity with UniProtKB:Q9UQ88

(Biggs and Zipursky, 1992)

inferred from biological aspect of ancestor with PANTHER:PTN000623091

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in positive regulation of antimicrobial peptide production

inferred from mutant phenotype

(Kanoh et al., 2015)

involved_in positive regulation of Toll signaling pathway

inferred from mutant phenotype

(Kanoh et al., 2015)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000623091

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CYCLIN DEPENDENT KINASES

Pathway (FlyBase)

POSITIVE REGULATORS OF TOLL-NF-kappaB SIGNALING PATHWAY

Protein Family (UniProt)

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (Q9VPC0)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

cyclin-dependent protein serine/threonine kinase activity

(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (2.7.11.22)

(2) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (2.7.11.22)

protein serine/threonine kinase activity

Summaries

Gene Group (FlyBase)

CYCLIN DEPENDENT KINASES -: Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory cyclin subunit. (Adapted from PMID:25180339).

Pathway (FlyBase)

POSITIVE REGULATORS OF TOLL-NF-kappaB SIGNALING PATHWAY -: In Drosophila, the canonical Toll signaling pathway is initiated by the binding of a spatzle ligand to Toll (Tl) or a Toll-like receptor leading to the nuclear localization of the NF-κB (dl or Dif) transcription factor. Positive regulators of Toll-NF-κB Signaling lead to the increased nuclear accumulation of the NF-κB proteins and regulated expression of target genes. (Adapted from FBrf0091014 and FBrf0223077).

Protein Function (UniProtKB)

(UniProt, Q9VPC0)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pitslre for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPC0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pitslre-RA

FBtr0078247

NM_140994

3355

952

Pitslre-RC

FBtr0078250

NM_168869

3296

952

Pitslre-RE

FBtr0304935

NM_001259922

4391

778

Pitslre-RF

FBtr0304936

NM_001259923

3620

778

Pitslre-RG

FBtr0331523

NM_001275193

3939

778

Additional Transcript Data and Comments

Reported size (kB)

7.1, 5.8, 4.9, 4.4, 3.6 (northern blot)

(Sauer et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Pitslre-PA

FBpp0077905

108.8

952

8.20

FBpp0077908

108.8

952

8.20

FBpp0293474

88.8

778

8.15

FBpp0293475

88.8

778

8.15

FBpp0303913

88.8

778

8.15

D3PFF6

NP_001262122

AGB94815

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

952 aa isoforms: Pitslre-PA, Pitslre-PC

778 aa isoforms: Pitslre-PE, Pitslre-PF, Pitslre-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

952 (aa)

(Sauer et al., 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pitslre using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Pitslre_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.35

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9

organism | faint

(Sauer et al., 1996)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 14

presumptive embryonic/larval central nervous system

(Sauer et al., 1996)

presumptive embryonic/larval nervous system

(Sauer et al., 1996)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & pupal stage & adult stage

(Sauer et al., 1996)

Additional Descriptive Data

The 3.6kb Pitslre transcript is detected in embryos, pupae, and adults on nothern blots and is maximally expressed in early embryos.

(Sauer et al., 1996)

Pitslre transcripts are ubiquitous in early embryos. They are also present at a low level throughout the embryo at later stages of embryogenesis. Stronger signals are observed in the CNS of late embryos.

(Sauer et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pitslre in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pitslre

View exonic expression by tissue for Dmel\Pitslre

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016696

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40292/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016696

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016696

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016696

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4268

Flygut - An atlas of the Drosophila adult midgut

FBgn0016696

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Pitslre

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pitslre

Transgenic constructs containing regulatory region of Pitslre

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pitslre^GD10516

lethal - all die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pitslre^GD10516

viable, with Scer\GAL4^tin.CΔ4

Pitslre^GD10516

Sterility

Allele

female sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Pitslre^GL00025

Other Phenotypes

Allele

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Pitslre^GD10516

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (35)

Hsap\CDK11A

12 of 14

Yes

Hsap\CDK11B

12 of 14

Yes

4 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Cdk11b

11 of 14

Yes

4 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (17)

Mmus\Cdk11b

12 of 14

Yes

4 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (25)

Xtro\cdk11b

7 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\srpk1

1 of 13

Danio rerio (Zebrafish) (17)

Drer\cdk11b

11 of 14

Yes

4 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\cdk-11.1

11 of 14

Yes

Cele\cdk-11.2

11 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP011055

11 of 12

Yes

4 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (57)

Atha\AT1G67580

10 of 13

Yes

Atha\AT5G63370

9 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\CDC28

1 of 13

Yes

Scer\CTK1

1 of 13

Yes

Scer\KIN28

1 of 13

Yes

Scer\KSS1

1 of 13

Yes

Scer\PHO85

1 of 13

Yes

Scer\SGV1

1 of 13

Yes

Scer\SMK1

1 of 13

Yes

Scer\SSN3

1 of 13

Yes

Scer\SWE1

1 of 13

Yes

Scer\YAK1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\ppk23

9 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Pitslre. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

8 of 13

5 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sgg

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CDK11A; cyclin dependent kinase 11A

12 of 14

116951

CDK11B; cyclin dependent kinase 11B

12 of 14

176873

CDK10; cyclin dependent kinase 10

4 of 14

603464

AL KAISSI SYNDROME; ALKAS

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Pitslre - Polr2A

anti bait coimmunoprecipitation, western blot, cosedimentation

(Andersen et al., 2010)

Pitslre - Rcd5

tandem affinity purification, Identification by mass spectrometry, cosedimentation, western blot, anti bait coimmunoprecipitation

(Andersen et al., 2010)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pbl

suppressible

Pitslre

(Gregory et al., 2007)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0016696

MIST (protein-protein) - An integrated Molecular Interaction Database

40292

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF TOLL-NF-kappaB SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VPC0

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47

Cytogenetic map

77E6-77E6

Sequence location

3L:20,771,528..20,776,931 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

77E6-77E6

Limits computationally determined from genome sequence between P{EP}trbl^EP3519 and P{EP}fng^EP3082&P{lacW}skd^L7062

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

77E-77E

(Lehner, 1996.7.23)

77E-77E

(determined by in situ hybridisation)

(Sauer et al., 1996)

Experimentally Determined Recombination Data

Location

3-47

(FlyBase, 2016)

3-43.7

(Comeron et al., 2012)

(Lehner, 1996.7.23)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

55066

w^*; P{UAS-Pitslre.N}3-1

55062

w^*; P{UAS-Pitslre.D703A}3

55065

P{UAS-Pitslre.K587M}4, w^*

55061

w^*; P{UAS-Pitslre.D703A}1/CyO

55063

w^*; P{UAS-Pitslre.K587M}1/CyO

55064

w^*; P{UAS-Pitslre.K587M}3/TM3, Sb¹

63481

w¹¹¹⁸; PBac{IT.GAL4}Pitslre^0699-G4

FlyORF

F001811

M{UAS-Pitslre.ORF}ZH-86Fb

F001244

M{UAS-Pitslre.ORF.3xHA}ZH-86Fb

Kyoto

104368

w^*; P{GawB}Pitslre^NP3083

VDRC

v107303

P{KK108225}VIE-260B

v45127

w¹¹¹⁸; P{GD10516}v45127

More stocks available...

Genomic Clones (32)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (90)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD39519

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0016696

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0016696

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against Pitslre that is transfected into S2 treated with Listeria monocytogenes reveals Pitslre to be involved in Listeria monocytogenes entry.

(Cheng et al., 2005)

Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.

(Nybakken et al., 2005)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R⁺ cells: cells become round and detached, cell morphology is aberrant and there is an increased frequency of microtubule-based mitotic spindles, indicative of a failure in mitosis. This phenotype is not seen in Kc167 cells.

(Kiger et al., 2003)

Characterisation of Pitslre.

(Sauer et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: Pitslre Gta

(Misra, 2000.7.28)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG4268

(Çiçek et al., 2016, Fukuoh et al., 2014, Schertel et al., 2013, Christis and Munro, 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Morrison et al., 2000)

Gat

Gta

PITSLRE

(Wilkinson et al., 2011, Bjorklund et al., 2006)

PitsIre

(Robinson et al., 2020, Appocher et al., 2014)

cdk11

(Andersen et al., 2010, Gregory et al., 2007)

group 3

(Biggs and Zipursky, 1992)

pitslre

(Kanoh et al., 2015, Zhang and Ten Hagen, 2010)

Name Synonyms

Galactosyltransferase-associated kinase-like

Gat-like

PITSLRE

(Lehner, 1996.7.23, Sauer et al., 1996)

PITSLRE kinase

(Boucher et al., 2001)

Pitslre

Secondary FlyBase IDs

FBgn0013968

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40292

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPC0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VPC0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

D3PFF6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPC0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016696

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40292/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016696

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016696

FlyMine - An integrated database for Drosophila genomics

FBgn0016696

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4268

MARRVEL_MODEL - MARRVEL (model organism gene)

40292

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0016696

DroID - A comprehensive database of gene and protein interactions.

FBgn0016696

DRSC - Results frm RNAi screens

FBgn0016696

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Pitslre_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016696

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0016696

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4268

Flygut - An atlas of the Drosophila adult midgut

FBgn0016696

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (protein-protein) - An integrated Molecular Interaction Database

40292

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VPC0

References (85)

The following external sites may use different assemblies or annotations than FlyBase.

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