FB2026_02 , released June 18, 2026
Gene: Dmel\meng
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General Information
Symbol
Dmel\meng
Species
D. melanogaster
Name
meng-po
Annotation Symbol
CG11221
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031855
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM). (UniProt, Q9VM90)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

PKN

Key Links
Genomic Location
Cytogenetic map
27A2-27B1
Sequence location
Recombination map
2-22
RefSeq locus
NT_033779 REGION:6742502..6756133
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271
(InterPro Project Members, 2004-)
enables protein serine kinase activity
inferred from experiment
(Lee et al., 2018)
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000684417
(GO Reference Genome Project, 2011-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in long-term memory
inferred from mutant phenotype
(Lee et al., 2018)
involved_in medium-term memory
inferred from mutant phenotype
(Lee et al., 2018)
involved_in positive regulation of gene expression
inferred from mutant phenotype
(Lee et al., 2018)
inferred from genetic interaction with UniProtKB:P12370
(Lee et al., 2018)
involved_in short-term memory
inferred from mutant phenotype
(Lee et al., 2018)
NOT involved_in anesthesia-resistant memory
inferred from mutant phenotype
(Lee et al., 2018)
NOT involved_in learning
inferred from mutant phenotype
(Lee et al., 2018)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (Q9VM90)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein serine kinase activity
RHEA 17989:
Summaries
Gene Group (FlyBase)
UNCLASSIFIED CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
This group comprises conventional protein kinase domain kinases that do not classify under other groups in FlyBase.
Protein Function (UniProtKB)
Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM).
(UniProt, Q9VM90)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\meng for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VM90)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
meng-RA
FBtr0079303
NM_135226
1979
456
meng-RB
FBtr0339237
NM_001298759
2722
456
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
meng-PA
FBpp0078933
52.4
456
8.78
Q9VM90
NP_609070
AAF52433
meng-PB
FBpp0308344
52.4
456
8.78
Q9VM90
NP_001285688
AHN54203
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

456 aa isoforms: meng-PA, meng-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\meng using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.96

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\meng in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of meng
Transgenic constructs containing regulatory region of meng
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel7027
(Ryder, 2004.4.26)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (49)
Hsap\SBK1
12 of 14
Yes
Yes
2  
Hsap\SBK2
7 of 14
No
Yes
Hsap\SBK3
5 of 14
No
Yes
Hsap\AKT2
1 of 14
No
No
5  
Hsap\AKT3
1 of 14
No
No
Hsap\AURKB
1 of 14
No
No
1  
Hsap\AURKC
1 of 14
No
No
Hsap\CAMK1G
1 of 14
No
No
Hsap\CAMK2A
1 of 14
No
No
5  
Hsap\CAMK2D
1 of 14
No
No
1  
Hsap\CAMK4
1 of 14
No
No
Hsap\CHEK1
1 of 14
No
No
1  
Hsap\CHEK2
1 of 14
No
No
Hsap\DCLK1
1 of 14
No
No
Hsap\DCLK3
1 of 14
No
No
Hsap\HUNK
1 of 14
No
No
Hsap\MARK1
1 of 14
No
No
2  
Hsap\MARK2
1 of 14
No
No
3  
Hsap\MARK3
1 of 14
No
No
2  
Hsap\MARK4
1 of 14
No
No
4  
Hsap\MELK
1 of 14
No
Yes
Hsap\NIM1K
1 of 14
No
No
Hsap\NUAK1
1 of 14
No
No
2  
Hsap\NUAK2
1 of 14
No
No
2  
Hsap\PNCK
1 of 14
No
No
1  
Hsap\PRKAA1
1 of 14
No
No
2  
Hsap\PRKAA2
1 of 14
No
No
Hsap\PRKACA
1 of 14
No
No
Hsap\PRKACG
1 of 14
No
No
Hsap\PRKCE
1 of 14
No
No
Hsap\PRKCH
1 of 14
No
No
Hsap\PRKCI
1 of 14
No
No
Hsap\PRKCZ
1 of 14
No
No
Hsap\PRKD1
1 of 14
No
No
2  
Hsap\PRKD2
1 of 14
No
No
1  
Hsap\PRKD3
1 of 14
No
No
1  
Hsap\ROCK1
1 of 14
No
No
Hsap\ROCK2
1 of 14
No
No
1  
Hsap\RPS6KA2
1 of 14
No
No
Hsap\RPS6KA5
1 of 14
No
No
Hsap\RPS6KA6
1 of 14
No
No
1  
Hsap\SIK1B
1 of 14
No
No
Hsap\SIK1
1 of 14
No
No
1  
Hsap\SIK2
1 of 14
No
No
Hsap\SIK3
1 of 14
No
No
Hsap\STK32A
1 of 14
No
No
1  
Hsap\STK32C
1 of 14
No
No
1  
Hsap\TSSK2
1 of 14
No
No
1  
Hsap\TSSK6
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (48)
Rnor\Sbk1
11 of 14
Yes
Yes
Rnor\Sbk2
7 of 14
No
Yes
Rnor\Sbk3
5 of 14
No
Yes
Rnor\Akt2
1 of 14
No
No
Rnor\Aurkb
1 of 14
No
No
Rnor\Camk1g
1 of 14
No
No
Rnor\Camk2a
1 of 14
No
No
6  
Rnor\Camk2b
1 of 14
No
No
Rnor\Camk2d
1 of 14
No
No
Rnor\Camk4
1 of 14
No
No
Rnor\Chek1
1 of 14
No
No
Rnor\Chek2
1 of 14
No
No
Rnor\Dclk1
1 of 14
No
No
Rnor\Dclk2
1 of 14
No
No
Rnor\Dclk3
1 of 14
No
No
Rnor\Hunk
1 of 14
No
No
Rnor\LOC300308
1 of 14
No
No
Rnor\LOC301165
1 of 14
No
No
Rnor\LOC690235
1 of 14
No
No
Rnor\LOC100911229
1 of 14
No
No
Rnor\LOC102551633
1 of 14
No
No
Rnor\LOC102555239
1 of 14
No
No
Rnor\LOC120093110
1 of 14
No
Yes
Rnor\Mark1
1 of 14
No
No
Rnor\Mark2
1 of 14
No
No
Rnor\Mark3
1 of 14
No
No
Rnor\Mark4
1 of 14
No
No
Rnor\Melk
1 of 14
No
Yes
Rnor\Nim1k
1 of 14
No
No
Rnor\Nuak1
1 of 14
No
No
Rnor\Pnck
1 of 14
No
No
Rnor\Prkaa1
1 of 14
No
No
Rnor\Prkaa2
1 of 14
No
No
Rnor\Prkaca
1 of 14
No
No
Rnor\Prkch
1 of 14
No
No
Rnor\Prkci
1 of 14
No
No
Rnor\Prkcz
1 of 14
No
No
Rnor\Prkd1
1 of 14
No
No
Rnor\Prkd3
1 of 14
No
No
Rnor\RGD1560303
1 of 14
No
No
Rnor\RGD1562638
1 of 14
No
No
Rnor\RGD1565071
1 of 14
No
No
Rnor\Rock1
1 of 14
No
No
Rnor\Rps6ka2
1 of 14
No
No
Rnor\Sik1
1 of 14
No
No
Rnor\Sik2
1 of 14
No
No
Rnor\Stk32a
1 of 14
No
No
Rnor\Tssk6
1 of 14
No
No
Mus musculus (laboratory mouse) (59)
Mmus\Sbk1
12 of 14
Yes
Yes
Mmus\Sbk2
6 of 14
No
Yes
Mmus\Sbk3
5 of 14
No
Yes
Mmus\4921509C19Rik
1 of 14
No
No
Mmus\Akt2
1 of 14
No
No
Mmus\Aurkb
1 of 14
No
No
Mmus\Camk1g
1 of 14
No
No
Mmus\Camk2a
1 of 14
No
No
1  
Mmus\Camk2b
1 of 14
No
No
Mmus\Camk2d
1 of 14
No
No
Mmus\Camk4
1 of 14
No
No
Mmus\Chek1
1 of 14
No
No
Mmus\Chek2
1 of 14
No
No
Mmus\Dclk1
1 of 14
No
No
Mmus\Dclk2
1 of 14
No
No
Mmus\Dclk3
1 of 14
No
No
Mmus\Gm4513
1 of 14
No
Yes
Mmus\Gm4565
1 of 14
No
Yes
Mmus\Gm4567
1 of 14
No
No
Mmus\Gm5157
1 of 14
No
No
Mmus\Gm5890
1 of 14
No
Yes
Mmus\Gm5891
1 of 14
No
No
Mmus\Gm6176
1 of 14
No
No
Mmus\Gm6882
1 of 14
No
No
Mmus\Gm6902
1 of 14
No
Yes
Mmus\Gm7168
1 of 14
No
No
Mmus\Gm7356
1 of 14
No
No
Mmus\Gm7358
1 of 14
No
No
Mmus\Gm10662
1 of 14
No
No
Mmus\Gm10668
1 of 14
No
No
Mmus\Gm14147
1 of 14
No
No
Mmus\Gm14151
1 of 14
No
No
Mmus\Hunk
1 of 14
No
No
Mmus\Mark1
1 of 14
No
No
Mmus\Mark2
1 of 14
No
No
Mmus\Mark3
1 of 14
No
No
Mmus\Mark4
1 of 14
No
No
Mmus\Melk
1 of 14
No
Yes
Mmus\Nim1k
1 of 14
No
No
Mmus\Nuak1
1 of 14
No
No
Mmus\Nuak2
1 of 14
No
No
Mmus\Pnck
1 of 14
No
No
Mmus\Prkaa1
1 of 14
No
No
Mmus\Prkaa2
1 of 14
No
No
Mmus\Prkaca
1 of 14
No
No
Mmus\Prkce
1 of 14
No
No
Mmus\Prkch
1 of 14
No
No
Mmus\Prkci
1 of 14
No
No
Mmus\Prkcz
1 of 14
No
No
3  
Mmus\Prkd1
1 of 14
No
No
Mmus\Prkd3
1 of 14
No
No
Mmus\Rock1
1 of 14
No
No
Mmus\Rps6ka2
1 of 14
No
No
Mmus\Sik1
1 of 14
No
No
Mmus\Sik2
1 of 14
No
No
Mmus\Sik3
1 of 14
No
No
Mmus\Smok2a
1 of 14
No
No
Mmus\Smok2b
1 of 14
No
No
Mmus\Stk32a
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (37)
Xtro\bsk146
7 of 13
Yes
Yes
Xtro\sbk3
7 of 13
Yes
Yes
Xtro\itm2a
6 of 13
No
Yes
Xtro\sbk1l2
6 of 13
No
Yes
Xtro\sbk1l
6 of 13
No
Yes
Xtro\sbk2
6 of 13
No
Yes
Xtro\tmem52
6 of 13
No
Yes
Xtro\alpk3
5 of 13
No
Yes
Xtro\sbk1
5 of 13
No
Yes
Xtro\acly
1 of 13
No
No
Xtro\camk1g
1 of 13
No
No
Xtro\camk1
1 of 13
No
No
Xtro\camk2a
1 of 13
No
No
Xtro\chek2
1 of 13
No
No
Xtro\dclk3
1 of 13
No
No
Xtro\hunk
1 of 13
No
Yes
Xtro\impa1
1 of 13
No
No
Xtro\LOC100145764
1 of 13
No
No
Xtro\LOC100485259
1 of 13
No
No
Xtro\LOC101731388
1 of 13
No
Yes
Xtro\LOC101734050
1 of 13
No
Yes
Xtro\LOC105947923
1 of 13
No
Yes
Xtro\LOC116406512
1 of 13
No
No
Xtro\mark1
1 of 13
No
No
Xtro\mark2
1 of 13
No
No
Xtro\mark4
1 of 13
No
No
Xtro\melk
1 of 13
No
Yes
Xtro\nuak1
1 of 13
No
No
Xtro\nuak2
1 of 13
No
No
Xtro\pkn3
1 of 13
No
No
Xtro\prkaa1
1 of 13
No
No
Xtro\prkaca
1 of 13
No
No
Xtro\rock1
1 of 13
No
No
Xtro\sik3
1 of 13
No
Yes
Xtro\snrk
1 of 13
No
No
Xtro\stk32c
1 of 13
No
No
Xtro\wdr36
1 of 13
No
No
Danio rerio (Zebrafish) (54)
Drer\bsk146
12 of 14
Yes
Yes
Drer\sbk1
12 of 14
Yes
Yes
Drer\unm_sa1261
12 of 14
Yes
Yes
Drer\si:dkey-8e10.3
6 of 14
No
Yes
Drer\sbk3
4 of 14
No
Yes
Drer\si:ch211-171h4.3
3 of 14
No
Yes
Drer\akt2
1 of 14
No
No
Drer\akt3b
1 of 14
No
No
Drer\aurkb
1 of 14
No
No
Drer\camk1a
1 of 14
No
No
Drer\camk1b
1 of 14
No
No
Drer\camk1da
1 of 14
No
No
Drer\camk1db
1 of 14
No
No
Drer\camk1ga
1 of 14
No
No
Drer\camk1gb
1 of 14
No
No
Drer\camk2a
1 of 14
No
No
Drer\camk2b1
1 of 14
No
No
Drer\camk2d1
1 of 14
No
No
Drer\camk4
1 of 14
No
No
Drer\chek2
1 of 14
No
No
Drer\LOC791840
1 of 14
No
Yes
Drer\LOC101885029
1 of 14
No
No
Drer\mark2a
1 of 14
No
No
Drer\mark2b
1 of 14
No
No
Drer\mark3a
1 of 14
No
No
Drer\mark3b
1 of 14
No
No
Drer\mark4b
1 of 14
No
No
Drer\mylk5
1 of 14
No
No
Drer\nim1ka
1 of 14
No
No
Drer\nim1kb
1 of 14
No
No
Drer\nuak1a
1 of 14
No
No
Drer\nuak1b
1 of 14
No
No
Drer\prkaa1
1 of 14
No
No
Drer\prkaa2
1 of 14
No
No
Drer\prkacaa
1 of 14
No
No
Drer\prkacab
1 of 14
No
No
Drer\prkcg
1 of 14
No
No
Drer\prkcha
1 of 14
No
No
Drer\prkchb
1 of 14
No
No
Drer\prkcz
1 of 14
No
No
Drer\prkd1
1 of 14
No
No
Drer\prkd2
1 of 14
No
No
Drer\prkd3
1 of 14
No
No
Drer\prkd4
1 of 14
No
No
Drer\pskh1
1 of 14
No
No
Drer\rock1
1 of 14
No
No
Drer\rps6ka2
1 of 14
No
No
Drer\si:ch73-60h1.1
1 of 14
No
No
Drer\sik1
1 of 14
No
No
Drer\sik2a
1 of 14
No
No
Drer\sik2b
1 of 14
No
No
Drer\sik3
1 of 14
No
No
Drer\stk33
1 of 14
No
No
Drer\stk36
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (27)
Cele\C01C4.3
11 of 14
Yes
Yes
Cele\aak-2
1 of 14
No
No
Cele\air-1
1 of 14
No
No
Cele\chk-1
1 of 14
No
No
Cele\chk-2
1 of 14
No
No
Cele\F32D8.1
1 of 14
No
No
Cele\F49C5.4
1 of 14
No
No
Cele\ikke-1
1 of 14
No
No
Cele\kin-1
1 of 14
No
No
Cele\kin-29
1 of 14
No
No
Cele\kin-33
1 of 14
No
No
Cele\M03C11.1
1 of 14
No
No
Cele\mlck-1
1 of 14
No
No
Cele\mnk-1
1 of 14
No
No
Cele\par-1
1 of 14
No
No
Cele\pkn-1
1 of 14
No
No
Cele\R02C2.1
1 of 14
No
No
Cele\rskn-1
1 of 14
No
No
Cele\tpa-1
1 of 14
No
No
Cele\txt-2
1 of 14
No
No
Cele\unc-43
1 of 14
No
No
Cele\unc-82
1 of 14
No
No
Cele\W04B5.5
1 of 14
No
No
Cele\Y39G8B.5
1 of 14
No
No
Cele\Y43D4A.6
1 of 14
No
No
Cele\Y50D7A.3
1 of 14
No
No
Cele\ZK524.4
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (15)
Agam\AgaP_AGAP009934
12 of 12
Yes
Yes
Agam\AgaP_AGAP010327
5 of 12
No
No
Agam\AgaP_AGAP000028
1 of 12
No
No
Agam\AgaP_AGAP001752
1 of 12
No
No
Agam\AgaP_AGAP002686
1 of 12
No
No
Agam\AgaP_AGAP002748
1 of 12
No
No
Agam\AgaP_AGAP003005
1 of 12
No
No
Agam\AgaP_AGAP003040
1 of 12
No
No
Agam\AgaP_AGAP003174
1 of 12
No
No
Agam\AgaP_AGAP006411
1 of 12
No
No
Agam\AgaP_AGAP007855
1 of 12
No
No
Agam\AgaP_AGAP008118
1 of 12
No
No
Agam\AgaP_AGAP008341
1 of 12
No
No
Agam\AgaP_AGAP012064
1 of 12
No
No
Agam\AgaP_AGAP013439
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (45)
Atha\AT1G04210
1 of 13
Yes
Yes
Atha\AT3G61960
1 of 13
Yes
No
Atha\AUR1
1 of 13
Yes
No
Atha\AUR2
1 of 13
Yes
No
Atha\AUR3
1 of 13
Yes
No
Atha\CDPK6
1 of 13
Yes
No
Atha\CIPK1
1 of 13
Yes
No
Atha\CIPK3
1 of 13
Yes
No
Atha\CIPK4
1 of 13
Yes
No
Atha\CIPK5
1 of 13
Yes
No
Atha\CIPK7
1 of 13
Yes
No
Atha\CIPK8
1 of 13
Yes
No
Atha\CIPK9
1 of 13
Yes
No
Atha\CIPK12
1 of 13
Yes
No
Atha\CIPK13
1 of 13
Yes
No
Atha\CIPK15
1 of 13
Yes
No
Atha\CIPK16
1 of 13
Yes
No
Atha\CIPK18
1 of 13
Yes
Yes
Atha\CIPK19
1 of 13
Yes
No
Atha\CIPK20
1 of 13
Yes
No
Atha\CIPK21
1 of 13
Yes
No
Atha\CIPK23
1 of 13
Yes
No
Atha\CIPK25
1 of 13
Yes
No
Atha\CIPK26
1 of 13
Yes
No
Atha\CPK16
1 of 13
Yes
No
Atha\CPK18
1 of 13
Yes
No
Atha\FU
1 of 13
Yes
No
Atha\KIN10
1 of 13
Yes
No
Atha\KIN11
1 of 13
Yes
No
Atha\OST1
1 of 13
Yes
No
Atha\PDK1
1 of 13
Yes
No
Atha\PEPKR1
1 of 13
Yes
No
Atha\PEPKR2
1 of 13
Yes
No
Atha\PPCK2
1 of 13
Yes
No
Atha\SIP1
1 of 13
Yes
No
Atha\SIP3
1 of 13
Yes
No
Atha\SIP4
1 of 13
Yes
No
Atha\SnRK1.3
1 of 13
Yes
No
Atha\SNRK2-8
1 of 13
Yes
No
Atha\SNRK2.1
1 of 13
Yes
No
Atha\SNRK2.2
1 of 13
Yes
No
Atha\SNRK2.3
1 of 13
Yes
No
Atha\SNRK2.5
1 of 13
Yes
No
Atha\SNRK2.7
1 of 13
Yes
No
Atha\SOS2
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\CHK1
1 of 13
Yes
No
Scer\FPK1
1 of 13
Yes
No
Scer\KIN2
1 of 13
Yes
No
Scer\RAD53
1 of 13
Yes
No
Scer\SNF1
1 of 13
Yes
No
Scer\TPK1
1 of 13
Yes
No
Scer\TPK2
1 of 13
Yes
No
Scer\TPK3
1 of 13
Yes
No
Scer\YPL150W
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\ark1
1 of 12
Yes
No
Spom\cds1
1 of 12
Yes
No
Spom\chk1
1 of 12
Yes
No
Spom\mek1
1 of 12
Yes
No
Spom\ppk16
1 of 12
Yes
Yes
Spom\srk1
1 of 12
Yes
No
Spom\ssp2
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:meng. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (16)
CG4945
11 of 13
AMPKα
1 of 13
aPKC
1 of 13
CaMKI
1 of 13
CaMKII
1 of 13
grp
1 of 13
inaC
1 of 13
KP78a
1 of 13
KP78b
1 of 13
lok
1 of 13
par-1
1 of 13
Pkc53E
1 of 13
S6kII
1 of 13
Sik2
1 of 13
Sik3
1 of 13
Snrk
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SBK1; SH3 domain binding kinase 1
    12 of 14
    620212
         
        SBK2; SH3 domain binding kinase family member 2
        7 of 14
        620414
            SBK3; SH3 domain binding kinase family member 3
            5 of 14
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Interaction Browsers
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Smox
                suppressible
                meng
                (Hevia et al., 2017)
                External Data
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                External Data
                Linkouts
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map
                2-22
                Cytogenetic map
                27A2-27B1
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                27A2-27B1
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Experimentally Determined Recombination Data
                Location

                2-22

                (FlyBase, 2016)

                2-21.6

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (16)
                Genomic Clones (27)
                cDNA Clones (22)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                      (Kiger et al., 2003)
                      Relationship to Other Genes
                      Source for database merge of
                      Additional comments
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: meng CG11221

                      (Lee et al., 2018)
                      Nomenclature comments
                      Etymology

                      The gene is named 'meng-po' based on memory phenotypes; Meng-Po is a character in Chinese mythology (the Lady of Forgetfulness) who ensures that people are ready for reincarnation by providing the 'Tea of Forgetfulness' so they lose memory associated with their former life.

                      (Lee et al., 2018)
                      Synonyms and Secondary IDs (6)
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 32 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                      References (51)