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General Information
Name
OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES
Species
D. melanogaster
Symbol
O-PK
FlyBase ID
FBgg0000248
Date last reviewed
2015-03-25
Number of members
41
Description
Description
The group of 'other conventional protein kinase domain kinases' consists of kinases with a conventional eukaryotic protein kinase domain that do not fit into any of the other major groups. This grouping is described in FBrf0201870.
Notes on Group

Although Wee1 is functionally a tyrosine kinase, its sequence more similar to serine/threonine kinases (PMID:15837193). It is therefore listed in both OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES and NON-RECEPTOR TYROSINE KINASES gene groups.

Madm, Slob, CG8726, CG4041 and CG11486 are predicted to be pseudokinases based on sequence analysis in FBrf0209106. Wnk was predicted to be a pseudokinase in FBrf0209106, but was shown to be active in FBrf0222370.

Source Material
The OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES Gene Group has been compiled by FlyBase curators using the following publication(s): Braden and Neufeld, 2016, Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
Members (41)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Autophagy-related 1
l(3)00305, Autophagy-specific gene 1, unc-51, ULK1, DK-4
aurora A
aur, aurora, Aur-A, Aurora A kinase, ck10
aurora B
ial, Aurora B kinase, IplI-aurora-like kinase, DmAuroraB, ABK
Cdc7 kinase
l(1)G0148, l(1)G0149, l(1)G0461
I-kappaB kinase β
ird5, DmIKKβ, IKK, IKK-β, immune response deficient 5
I-kappaB kinase ε
ik2, DmIKKε, l(2)38Ea, 38D.31, IκB kinase-like 2
Inositol-requiring enzyme-1
ire-1, Ire
MLF1-adaptor molecule
lincRNA.S6031
Monopolar spindle 1
ald, dMps1, altered disjunction
Poly(A) specific ribonuclease subunit PAN3
polyA-nuclease related
pancreatic eIF-2α kinase
PERK, dPerk
PTEN-induced putative kinase 1
dPINK1, Pink
polo
Polo kinase, l(3)01673, Plk1, l(3)77Aa
Slowpoke binding protein
SLO-binding protein
Threonyl-carbamoyl synthesis 5
Prpk, p53-related protein kinase
Tousled-like kinase
l(1)G0054, BEST:GH17330, BcDNA:GH07910, EP1413
Vacuolar protein sorting 15
ird1, immune response deficient 1, immune response-deficient 1
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
O-PK
OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES
Secondary FlyBase ID(s)
References (6)