FB2026_02 , released June 18, 2026
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Mast, J., DiPrimio, N. (2019.3.12). S6kII alleles from Perlara. 
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FBrf0241755
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Personal communication to FlyBase
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The following information accompanied stocks donated to the Bloomington Drosophila Stock Center by Joshua Mast and Nina DiPrimio, Perlara PBC.
S6kIIK347E - CRISPR/Cas9-mediated homologous dependent repair was used to make amino acid change K347E change in S6kII.  This change was designed to mimic the K216E change found in a human RPS6KA3 variant associated with Coffin-Lowry syndrome.
TI{TI}S6kIIKO - CRISPR/Cas9-mediated homologous dependent repair was used to replace a 3177 region encompassing the entire S6kII coding region (from -55 nt to +3122 relative to the start ATG) with a cassette carrying lox-P flanked 3xP3-RFP. The result is a null allele of S6kII.
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    English
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    Alleles (2)
    Genes (1)
    Human Disease Models (1)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (1)