FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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Term intracellular signal transduction ID (Ontology) GO:0035556 (Gene Ontology)
Definition The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.[ ISBN:3527303782 ]
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Genes (FBgn)GO_BIOLOGICAL_PROCESS
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 intracellular signal transduction (all annotations which use CV term, excluding "NOT" statements)
     involved_in | intracellular signal transduction
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cell communication______________
cellular process________________|
signaling_______________________|
regulation of cellular process__|
cellular response to stimulus___|
                                signal transduction
                                 |__intracellular signal transduction  782 rec.
                                     |__cell cycle checkpoint signaling 58 rec.
                                     |   |__DNA integrity checkpoint signaling(+) 39 rec.
                                     |   |__meiotic cell cycle checkpoint signaling(+) 4 rec.
                                     |   |__mitotic cell cycle checkpoint signaling(+) 40 rec.
                                     |   |__regulation of cell cycle checkpoint(+) 6 rec.
                                     |   |__spindle checkpoint signaling(+) 14 rec.
                                     |__chloroplast-nucleus signaling pathway
                                     |__endoplasmic reticulum unfolded protein response 25 rec.
                                     |   |__ATF6-mediated unfolded protein response(+)
                                     |   |__IRE1-mediated unfolded protein response(+) 4 rec.
                                     |   |__PERK-mediated unfolded protein response(+) 2 rec.
                                     |   |__regulation of endoplasmic reticulum unfolded protein response(+) 4 rec.
                                     |__ER-nucleus signaling pathway 7 rec.
                                     |   |__ATF6-mediated unfolded protein response(+)
                                     |   |__ER overload response(+)
                                     |   |__PERK-mediated unfolded protein response(+) 2 rec.
                                     |   |__SREBP signaling pathway(+) 5 rec.
                                     |__hippo signaling 100 rec.
                                     |   |__regulation of hippo signaling(+) 93 rec.
                                     |__hypoxia-inducible factor-1alpha signaling pathway
                                     |   |__regulation of hypoxia-inducible factor-1alpha signaling pathway(+)
                                     |__intracellular receptor signaling pathway 33 rec.
                                     |   |__blue light signaling pathway 1 rec.
                                     |   |__cytoplasmic pattern recognition receptor signaling pathway(+) 9 rec.
                                     |   |__juvenile hormone mediated signaling pathway 5 rec.
                                     |   |__nuclear receptor-mediated signaling pathway(+) 16 rec.
                                     |__intracellular signaling cassette 425 rec.
                                     |   |__calcium-mediated signaling(+) 38 rec.
                                     |   |__cAMP/PKA signal transduction(+) 9 rec.
                                     |   |__canonical NF-kappaB signal transduction(+) 14 rec.
                                     |   |__integrated stress response signaling(+) 2 rec.
                                     |   |__MAPK cascade(+) 160 rec.
                                     |   |__nitric oxide-cGMP-mediated signaling(+) 5 rec.
                                     |   |__non-canonical NF-kappaB signal transduction(+) 3 rec.
                                     |   |__phosphatidylinositol 3-kinase/protein kinase B signal transduction(+) 33 rec.
                                     |   |__phospholipase C/protein kinase C signal transduction
                                     |   |__SMAD protein signal transduction(+) 11 rec.
                                     |   |__small GTPase-mediated signal transduction(+) 191 rec.
                                     |__intrinsic apoptotic signaling pathway 26 rec.
                                     |   |__intrinsic apoptotic signaling pathway by p53 class mediator(+) 8 rec.
                                     |   |__intrinsic apoptotic signaling pathway in response to DNA damage(+) 13 rec.
                                     |   |__intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(+) 6 rec.
                                     |   |__intrinsic apoptotic signaling pathway in response to hypoxia(+)
                                     |   |__intrinsic apoptotic signaling pathway in response to nitrosative stress(+)
                                     |   |__intrinsic apoptotic signaling pathway in response to osmotic stress(+)
                                     |   |__intrinsic apoptotic signaling pathway in response to oxidative stress(+) 2 rec.
                                     |   |__regulation of intrinsic apoptotic signaling pathway(+) 9 rec.
                                     |__mitochondria-nucleus signaling pathway
                                     |__osmosensory signaling pathway
                                     |   |__osmosensory signaling pathway via Sho1 osmosensor
                                     |   |__osmosensory signaling via phosphorelay pathway
                                     |__phosphatidylinositol-mediated signaling 10 rec.
                                     |__phosphorelay signal transduction system
                                     |   |__ethylene-activated signaling pathway(+)
                                     |   |__osmosensory signaling via phosphorelay pathway
                                     |   |__regulation of phosphorelay signal transduction system(+)
                                     |__protein kinase C signaling 1 rec.
                                     |   |__regulation of protein kinase C signaling(+)
                                     |__RAM/MOR signaling
                                     |__regulation of intracellular signal transduction 443 rec.
                                     |   |__negative regulation of intracellular signal transduction(+) 153 rec.
                                     |   |__positive regulation of intracellular signal transduction(+) 230 rec.
                                     |   |__regulation of calcium-mediated signaling(+) 18 rec.
                                     |   |__regulation of cAMP/PKA signal transduction(+) 8 rec.
                                     |   |__regulation of canonical NF-kappaB signal transduction(+) 11 rec.
                                     |   |__regulation of cell cycle checkpoint(+) 6 rec.
                                     |   |__regulation of cytoplasmic pattern recognition receptor signaling pathway(+) 2 rec.
                                     |   |__regulation of endoplasmic reticulum unfolded protein response(+) 4 rec.
                                     |   |__regulation of hippo signaling(+) 93 rec.
                                     |   |__regulation of hypoxia-inducible factor-1alpha signaling pathway(+)
                                     |   |__regulation of intracellular steroid hormone receptor signaling pathway(+) 10 rec.
                                     |   |__regulation of intrinsic apoptotic signaling pathway(+) 9 rec.
                                     |   |__regulation of MAPK cascade(+) 139 rec.
                                     |   |__regulation of nitric oxide-cGMP mediated signal transduction(+)
                                     |   |__regulation of non-canonical NF-kappaB signal transduction(+) 1 rec.
                                     |   |__regulation of peroxisome proliferator activated receptor signaling pathway(+)
                                     |   |__regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction(+) 28 rec.
                                     |   |__regulation of phosphorelay signal transduction system(+)
                                     |   |__regulation of protein kinase C signaling(+)
                                     |   |__regulation of retinoic acid receptor signaling pathway(+)
                                     |   |__regulation of signal transduction by p53 class mediator(+) 4 rec.
                                     |   |__regulation of SMAD protein signal transduction(+) 8 rec.
                                     |   |__regulation of small GTPase mediated signal transduction(+) 96 rec.
                                     |   |__regulation of SREBP signaling pathway(+) 1 rec.
                                     |   |__regulation of stress-activated protein kinase signaling cascade(+) 5 rec.
                                     |   |__regulation of thyroid hormone receptor signaling pathway(+)
                                     |   |__regulation of TOR signaling(+) 67 rec.
                                     |   |__regulation of vitamin D receptor signaling pathway(+)
                                     |__signal transduction by p53 class mediator 10 rec.
                                     |   |__DNA damage response, signal transduction by p53 class mediator(+) 4 rec.
                                     |   |__intrinsic apoptotic signaling pathway by p53 class mediator(+) 8 rec.
                                     |   |__regulation of signal transduction by p53 class mediator(+) 4 rec.
                                     |__signal transduction in response to DNA damage 38 rec.
                                     |   |__DNA damage checkpoint signaling(+) 34 rec.
                                     |   |__DNA damage response, signal transduction by p53 class mediator(+) 4 rec.
                                     |   |__DNA damage response, signal transduction resulting in transcription
                                     |__stress-activated protein kinase signaling cascade 7 rec.
                                     |   |__regulation of stress-activated protein kinase signaling cascade(+) 5 rec.
                                     |   |__stress-activated MAPK cascade(+) 5 rec.
                                     |__TOR signaling 83 rec.
                                         |__regulation of TOR signaling(+) 67 rec.
                                         |__TORC1 signaling(+) 60 rec.
                                         |__TORC2 signaling(+) 9 rec.
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Synonyms
  • "intracellular signal transduction pathway" NARROW
    "intracellular signaling cascade" RELATED
    "intracellular signaling pathway" RELATED
    "signal transmission via intracellular cascade" NARROW
Secondary IDs
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