FlyBase Gene Report: Dmel\sff

General Information

Symbol

Dmel\sff

Species

D. melanogaster

Name

sugar-free frosting

Annotation Symbol

CG6114

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036544

Gene Model Status

Current

Stock Availability

41 publicly available

Enzyme Name (EC)

[tau protein] kinase (2.7.11.26)

Gene Summary

sugar-free frosting (sff) encodes a protein involved in neuromuscular junction development and protein N-linked glycosylation. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

72A4-72B1

Sequence location

3L:15,900,156..15,924,861 [-]

Recombination map

3-43

RefSeq locus

NT_037436 REGION:15900156..15924861

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from sequence or structural similarity with WB:WBGene00004719

(Baas et al., 2011)

enables tau-protein kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000679673

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in neuromuscular junction development

inferred from mutant phenotype

(Baas et al., 2011)

involved_in protein N-linked glycosylation

inferred from mutant phenotype

(Baas et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in axonogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000679673

(GO Reference Genome Project, 2011-)

involved_in establishment of cell polarity

inferred from biological aspect of ancestor with PANTHER:PTN000679673

(GO Reference Genome Project, 2011-)

involved_in G2/M transition of mitotic cell cycle

inferred from biological aspect of ancestor with PANTHER:PTN008613667

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from sequence or structural similarity with UniProtKB:Q8TDC3

(Gene Ontology Curators, 2002-)

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:Q8TDC3

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

tau-protein kinase activity

(1) L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+) (2.7.11.26)

(2) L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+) (2.7.11.26)

Summaries

Gene Snapshot

sugar-free frosting (sff) encodes a protein involved in neuromuscular junction development and protein N-linked glycosylation. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES -: The Calcium/Calmodulin-dependent kinase family are serine/threonine kinases which, in general, prefer substrates containing basic residues. Many, but not all, members are regulated by calcium or calmodulin. (Adapted from FBrf0132098).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\sff for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VUV4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

sff-RA

FBtr0089527

NM_140557

6785

861

sff-RB

FBtr0334070

NM_001274972

6737

845

sff-RC

FBtr0334071

NM_001274973

6755

851

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

sff-PA

FBpp0088511

95.3

861

9.38

FBpp0306195

93.6

845

9.52

FBpp0306196

94.2

851

9.52

M9PFM1

NP_001261902

AGB94595

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sff using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sff_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.77

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11

ventral midline of embryo

(Baas et al., 2011)

embryonic stage 11 -- 17

larval ventral nerve cord

(Baas et al., 2011)

embryonic stage 13 -- 17

sensory neuron of larval peripheral nervous system

(Baas et al., 2011)

Additional Descriptive Data

sff transcripts are detected in the

(Baas et al., 2011)

embryonic ventral nerve cord and peripheral sensory clusters in the

(Baas et al., 2011)

ventral and lateral ectoderm

(Baas et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\sff in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sff

View exonic expression by tissue for Dmel\sff

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39732/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036544

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036544

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036544

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6114

Flygut - An atlas of the Drosophila adult midgut

FBgn0036544

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sff

Transgenic constructs containing regulatory region of sff

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)brm11

(Baas et al., 2011)

Gene not disrupted in

Df(3L)th102

(Baas et al., 2011)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

sff^GD11823

partially lethal - majority live

sff^B22

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

sff^GD11823

viable, with Scer\GAL4^Mef2.PR

sff^GD11823

viable, with Scer\GAL4^tin.CΔ4

sff^GD11823

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage | recessive

sff^B22

some die during pupal stage, with Scer\GAL4^pnr-MD237

sff^GD11823

Phenotype manifest in

Allele

embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4^Pxn.PS

sff^EY08774

embryonic/larval neuromuscular junction

sff^B22

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (70)

Hsap\BRSK2

14 of 14

Yes

Hsap\BRSK1

12 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PIM2

1 of 14

Yes

Hsap\PIM3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Hsap\SIK1B

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (65)

Rnor\Brsk1

12 of 14

Yes

Rnor\Brsk2

12 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (78)

Mmus\Brsk2

13 of 14

Yes

Mmus\Brsk1

11 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gm4565

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (46)

Xtro\brsk2

8 of 13

Yes

Xtro\brsk1

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\pim3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (70)

Drer\brsk2a

14 of 14

Yes

Drer\brsk2b

14 of 14

Yes

Drer\brsk1a

12 of 14

Yes

Drer\brsk1b

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC101885029

1 of 14

Drer\LOC101885707

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch73-122k23.1

1 of 14

Yes

Drer\si:ch211-63o20.7

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (42)

Cele\sad-1

12 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (33)

Agam\AgaP_AGAP012244

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (105)

Atha\KIN10

2 of 13

Yes

Atha\KIN11

2 of 13

Yes

Atha\SnRK1.3

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (35)

Scer\GIN4

7 of 13

Yes

Scer\HSL1

6 of 13

Yes

Scer\KCC4

5 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (21)

Spom\cdr2

6 of 12

Yes

Spom\cdr1

5 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:sff. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (37)

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

grp

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Akt

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

lok

1 of 13

Pak

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

SAK

1 of 13

sqa

1 of 13

sti

1 of 13

trbl

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BRSK2; BR serine/threonine kinase 2

14 of 14

609236

BRSK1; BR serine/threonine kinase 1

12 of 14

609235

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0036544

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q95T82

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-43

Cytogenetic map

72A4-72B1

Sequence location

3L:15,900,156..15,924,861 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

72A4-72B1

Limits computationally determined from genome sequence between P{EP}Tfb2^EP572 and P{lacW}th^j5C8&P{PZ}Mbs⁰³⁸⁰²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-43

(FlyBase, 2016)

3-37.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (41)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

38782

w¹¹¹⁸; P{GMR51E05-GAL4}attP2

Korea

12429

P{VT031493-GAL4}attP2

12690

P{VT031490-GAL4}attP2

13893

P{VT031495-GAL4}attP2

15843

P{VT031494-lexA::GADfl}attP40

16472

P{VT031495-lexA::GADfl}attP40

16473

P{VT031497-lexA::GADfl}attP40

17121

P{VT031493-lexA::GADfl}attP40

6114R-1

v100717

v200516

P{VT031497-GAL4}attP2

v22224

w¹¹¹⁸; P{GD11823}v22224/CyO

More stocks available...

Genomic Clones (36)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (39)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH13047

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036544

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

HL03762

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036544

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: sff CG6114

(Baas et al., 2011)

Nomenclature comments

Etymology

The appearance of residual anti-horse radish peroxidase (HRP) staining within the axon scaffold of the ventral nerve cord of homozygous "sff[B22]" mutant embryos is reminiscent of 'sugar-free frosting'.

(Baas et al., 2011)

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

BRSK1

(Couderc et al., 2017)

CG6114

(Couderc et al., 2017, Hosono et al., 2015, Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Baas et al., 2011, Ni et al., 2011.7.19, Shieh and Bonini, 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Stofanko et al., 2008)

sff

(Jin et al., 2026, Uçkun et al., 2021, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Montgomery et al., 2014, Izutsu et al., 2012, Baas et al., 2011)

Name Synonyms

SNF1-related

(Morrison et al., 2000)

sugar-free frosting

(Montgomery et al., 2014, Scott and Panin, 2014, Baas et al., 2011)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39732

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VUV4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VUV4

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39732/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036544

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036544

FlyMine - An integrated database for Drosophila genomics

FBgn0036544

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6114

MARRVEL_MODEL - MARRVEL (model organism gene)

39732

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036544

DroID - A comprehensive database of gene and protein interactions.

FBgn0036544

DRSC - Results frm RNAi screens

FBgn0036544

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sff_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036544

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036544

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6114

Flygut - An atlas of the Drosophila adult midgut

FBgn0036544

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015323

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q95T82

References (49)

The following external sites may use different assemblies or annotations than FlyBase.

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