FlyBase Gene Report: Dmel\Drak

General Information

Symbol

Dmel\Drak

Species

D. melanogaster

Name

Death-associated protein kinase related

Annotation Symbol

CG32666

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052666

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

Death-associated protein kinase related (Drak) encodes a protein serine/threonine kinase belonging to the Death-associated protein kinase family. It promotes phosphorylation of the product of sqh at sites known to stimulate actomyosin contractility. Its main characterized function is to shape epithelial tissues during development. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

10C1-10C5

Sequence location

X:11,493,135..11,555,045 [+]

Recombination map

1-35

RefSeq locus

NC_004354 REGION:11493135..11555045

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000678761

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived leg morphogenesis

inferred from mutant phenotype

(Neubueser and Hipfner, 2010)

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Neubueser and Hipfner, 2010)

involved_in morphogenesis of an epithelium

inferred from genetic interaction with FLYBASE:Rok; FB:FBgn0026181

(Neubueser and Hipfner, 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000678761

(GO Reference Genome Project, 2011-)

involved_in positive regulation of apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN000678761

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000678761

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (Q0KHT7)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES -: The Calcium/Calmodulin-dependent kinase family are serine/threonine kinases which, in general, prefer substrates containing basic residues. Many, but not all, members are regulated by calcium or calmodulin. (Adapted from FBrf0132098).

Summary (Interactive Fly)

regulation of myosin II dynamics - promotes proper morphogenesis of epithelial tissues during development - maintenance of furrow canal structure and lateral plasma membrane integrity during cellularization - morphogenesis of retina, functions during Myosin II-dependent cell constriction, subsequent multicellular alignment and adherens junction remodelling

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Drak for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q0KHT7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Drak-RC

FBtr0301020

NM_001169252

4525

674

Drak-RD

FBtr0301021

NM_001169253

4847

674

Drak-RE

FBtr0340295

NM_206688

4163

674

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Drak-PC

FBpp0290242

73.0

674

6.29

FBpp0290243

73.0

674

6.29

FBpp0309256

73.0

674

6.29

Q0KHT7

NP_996411

AAS65317

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

674 aa isoforms: Drak-PC, Drak-PD, Drak-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q0KHT7

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Drak using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.55

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

wing disc | ubiquitous

(Neubueser and Hipfner, 2010)

leg disc

(Neubueser and Hipfner, 2010)

haltere disc

(Neubueser and Hipfner, 2010)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism

(Neubueser and Hipfner, 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Drak in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Drak

View exonic expression by tissue for Dmel\Drak

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052666

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32097/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052666

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052666

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052666

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0052666

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Drak

Transgenic constructs containing regulatory region of Drak

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Drak^GD9422

viable

viable (with Drak^del)

Drak^KO

viable (with Drak^KO)

Drak^del

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

fertile

Other Phenotypes

Allele

decreased body size | adult stage, with Scer\GAL4^Ilp2.PR

flightless, with Scer\GAL4^Mef2.PR

Drak^GD9422

visible

visible, with Scer\GAL4^pnr-MD237

Drak^GD9422

Phenotype manifest in

Allele

chaeta | increased number, with Scer\GAL4^pnr-MD237

Drak^GD9422

metathoracic leg

myofibril, with Scer\GAL4^Mef2.PR

Drak^GD9422

wing

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (32)

Hsap\STK17B

8 of 14

Yes

Hsap\STK17A

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (26)

Rnor\Stk17b

8 of 14

Yes

Rnor\Dapk1

3 of 14

Yes

Rnor\Dapk2

3 of 14

Yes

Rnor\Dapk3

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (27)

Mmus\Stk17b

8 of 14

Yes

Mmus\Dapk1

3 of 14

Yes

Mmus\Dapk2

3 of 14

Yes

Mmus\Dapk3

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\LOC101732252

6 of 13

Yes

Xtro\stk17a

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (41)

Drer\stk17b

8 of 14

Yes

Drer\stk17a

7 of 14

Yes

Drer\stk17al

7 of 14

Yes

Drer\dapk3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-240h12.4

1 of 14

Drer\trioa

1 of 14

Drer\triob

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\dapk-1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (10)

Agam\AgaP_AGAP000713

8 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (35)

Atha\CDPK6

1 of 13

Yes

Atha\CDPK9

1 of 13

Yes

Atha\CDPK19

1 of 13

Yes

Atha\CIPK5

1 of 13

Yes

Atha\CIPK13

1 of 13

Yes

Atha\CIPK25

1 of 13

Yes

Atha\CPK1

1 of 13

Yes

Atha\CPK2

1 of 13

Yes

Atha\CPK5

1 of 13

Yes

Atha\CPK6

1 of 13

Yes

Atha\CPK7

1 of 13

Yes

Atha\CPK9

1 of 13

Yes

Atha\CPK15

1 of 13

Yes

Atha\CPK17

1 of 13

Yes

Atha\CPK18

1 of 13

Yes

Atha\CPK19

1 of 13

Yes

Atha\CPK20

1 of 13

Yes

Atha\CPK21

1 of 13

Yes

Atha\CPK22

1 of 13

Yes

Atha\CPK25

1 of 13

Yes

Atha\CPK26

1 of 13

Yes

Atha\CPK27

1 of 13

Yes

Atha\CPK28

1 of 13

Yes

Atha\CPK29

1 of 13

Yes

Atha\CPK30

1 of 13

Yes

Atha\CPK31

1 of 13

Yes

Atha\CPK32

1 of 13

Yes

Atha\CPK33

1 of 13

Yes

Atha\CPK34

1 of 13

Yes

Atha\MAPKKK7

1 of 13

Yes

Atha\PEPKR1

1 of 13

Yes

Atha\PEPKR2

1 of 13

Yes

Atha\SIK1

1 of 13

Yes

Atha\SIP4

1 of 13

Yes

Atha\SnRK1.3

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\PKH1

1 of 13

Yes

Scer\PKH2

1 of 13

Yes

Scer\TPK1

1 of 13

Yes

Scer\TPK3

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cmk1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Drak. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

sqa

2 of 13

Akt

1 of 13

CaMKI

1 of 13

CaMKII

1 of 13

Pka-C3

1 of 13

PKD

1 of 13

sff

1 of 13

Strn-Mlck

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

Drak^GD9422

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Butzlaff et al., 2015)

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Chen et al., 2019)

Drak^KK101989

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Chen et al., 2019)

Drak^del

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Chen et al., 2019)

modeled by btl::Egfr^λ.UAS

(Chen et al., 2019)

Drak^UAS.cCa

exacerbates high grade glioma

modeled by btl::Egfr^λ.UAS

(Chen et al., 2019)

Drak^KD.UAS

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Chen et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

STK17B; serine/threonine kinase 17b

8 of 14

604727

STK17A; serine/threonine kinase 17a

7 of 14

604726

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Drak

suppressible

flw

(Neubueser and Hipfner, 2010)

Rok|Drak

suppressible

flw

(Neubueser and Hipfner, 2010)

Drak

enhanceable

Rho1

(Neubueser and Hipfner, 2010)

Drak

enhanceable

(Neubueser and Hipfner, 2010)

Drak

suppressible

sqh

(Neubueser and Hipfner, 2010)

Rok|Drak

suppressible

sqh

(Neubueser and Hipfner, 2010)

Drak

enhanceable

zip

(Neubueser and Hipfner, 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

btl::Egfr

enhanceable

Drak

(Chen et al., 2019)

btl::Egfr

suppressible

Drak

(Chen et al., 2019)

flw

suppressible

Drak

(Neubueser and Hipfner, 2010)

Pi3K92E|btl::Egfr

suppressible

Drak

(Chen et al., 2019)

pnr

suppressible

Drak

(Pena-Rangel et al., 2002)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0052666

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q0KHT7

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-35

Cytogenetic map

10C1-10C5

Sequence location

X:11,493,135..11,555,045 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10C1-10C5

Limits computationally determined from genome sequence between P{EP}CG11756^EP1610 and P{EP}CG32666^EP1452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-35

(FlyBase, 2016)

1-36.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29449

y¹ v¹; P{TRiP.JF03385}attP2

55904

y¹ v¹; P{TRiP.HMC04188}attP2

13768

y¹ P{SUPor-P}Drak^KG03058/FM7c

51247

y¹ w^* Mi{MIC}Drak^MI09021

56620

y¹ w^* Mi{MIC}Drak^MI11582

77819

y¹ w^* Mi{Trojan-GAL4.2}Drak^{MI11582-TG4.2}

10842

11154

105140

y^* w^* P{GawB}Drak^NP6127 / FM7c

VDRC

v107263

P{KK101989}VIE-260B

v32960

w¹¹¹⁸; P{GD9422}v32960

v342374

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02363}attP40/CyO-GFP

More stocks available...

Genomic Clones (35)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (54)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE12147

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052666

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052666

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R⁺ cells: cells become round and detached.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG32666 EP1452

(FlyBase, 1996-)

Source for merge of: CG11713 CG1760

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG11713 and CG1760 merged as CG32666 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG32666 EP1452 was that EP1452 insertion is within CG32666 (and in the right orientation) ( date:040519 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Drak CG32666

(Neubueser and Hipfner, 2010)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG11713

CG1760

(Champagne et al., 2000, Morrison et al., 2000)

CG32666

(Butzlaff et al., 2015, Duff et al., 2015, Ashwal-Fluss et al., 2014, Esslinger et al., 2013, Takahashi et al., 2012, Desalvo et al., 2011, Luo et al., 2011, Ni et al., 2011.7.19, Neubueser and Hipfner, 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Mensch et al., 2008, Burnette et al., 2005, Liebl and Featherstone, 2005)

DRak

(Pichaud, 2014)

EP(X)1452

(Pena-Rangel et al., 2002)

EP1452

drak

(Deichsel et al., 2024, Neubueser and Hipfner, 2010)

Name Synonyms

Death-associated protein kinase related

(Córdoba and Estella, 2018, Pool et al., 2012)

Secondary FlyBase IDs

FBgn0030308
FBgn0040853
FBgn0062687

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 60 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32097

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q0KHT7

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q0KHT7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q0KHT7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0052666

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32097/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052666

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052666

FlyMine - An integrated database for Drosophila genomics

FBgn0052666

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32666

MARRVEL_MODEL - MARRVEL (model organism gene)

32097

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0052666

DroID - A comprehensive database of gene and protein interactions.

FBgn0052666

DRSC - Results frm RNAi screens

FBgn0052666

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052666

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052666

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0052666

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031247

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q0KHT7

References (88)

The following external sites may use different assemblies or annotations than FlyBase.

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