MLCK, myosin light chain kinase, A(225), Stretchin, Mlc-k
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Gene model reviewed during 5.48
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
Identified as a 'composite gene' (FBrf0129758), with non-overlapping isoforms.
18, 13, 5.2, 3.6 (northern blot)
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Strn-Mlck using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Strn-Mlck in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: A(225) CG18255
Source for merge of: Mlc-k A(225)
Source for merge of: Strn-Mlck BEST:GH22543
Source for merge of: Strn-Mlck BcDNA:RH74685
Source for merge of: Strn-Mlck CG15699
Annotations CG18255 and CG15699 merged as CG44162 in release 5.48 of the genome annotation. Merge supported by second tier modENCODE junction (FBrf0217580).
FBrf0100232 discusses 'zetalin' but subsequent work revealed that the gene corresponding to cDNA with accession number U51473 is actually "Strn-Mlck".
Source for merge of Strn-Mlck BcDNA:RH74685 was a shared cDNA ( date:030728 ).
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
This locus can be viewed as a single transcription unit, Strn-Mlck, that expresses large, composite transcripts and protein isoforms, as well as a complex of two independent transcription units ("Strn" and "Mlck" respectively) the result of a "gene fission" event, that encode independent transcripts and proteins with distinct structural and enzymatic functions.
Codes for a previously unidentified 225kD protein with repeating immunoglobulin C2-like domains that is associated with the A-band of myofibrils in indirect flight muscle.