FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\bdl
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General Information
Symbol
Dmel\bdl
Species
D. melanogaster
Name
borderless
Annotation Symbol
CG16857
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028482
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
borderless (bdl) encodes a cell adhesion molecule that is required for glial extension and axon ensheathment. Its down-regulation by the products of tutl and Lar is required for photoreceptor axonal tiling and layer-specific target selection. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BcDNA:GH11322

Key Links
Genomic Location
Cytogenetic map
24E1-24E1
Sequence location
Recombination map
2-12
RefSeq locus
NT_033779 REGION:4324554..4331830
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables cell-cell adhesion mediator activity
inferred from physical interaction with FLYBASE:tutl; FB:FBgn0010473
(Cameron et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables cell-cell adhesion mediator activity
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(GO Reference Genome Project, 2011-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in axon ensheathment
inferred from mutant phenotype
(Cameron et al., 2016)
involved_in axonal transport
inferred from mutant phenotype
(Shaw et al., 2019)
involved_in glial cell growth
inferred from mutant phenotype
(Cameron et al., 2016)
involved_in homophilic cell-cell adhesion
inferred from mutant phenotype
(Cameron et al., 2013)
involved_in neuron cell-cell adhesion
inferred from mutant phenotype
(Cameron et al., 2013)
involved_in R7 cell development
inferred from mutant phenotype
(Cameron et al., 2013)
inferred from genetic interaction with FLYBASE:tutl; FB:FBgn0010473
(Cameron et al., 2013)
involved_in response to light stimulus
inferred from mutant phenotype
(Shaw et al., 2019)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(GO Reference Genome Project, 2011-)
involved_in dendrite self-avoidance
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(GO Reference Genome Project, 2011-)
involved_in homophilic cell-cell adhesion
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in plasma membrane
inferred from direct assay
(Cameron et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in axon
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001296633
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the immunoglobulin superfamily. (Q9U4G1)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
borderless (bdl) encodes a cell adhesion molecule that is required for glial extension and axon ensheathment. Its down-regulation by the products of tutl and Lar is required for photoreceptor axonal tiling and layer-specific target selection. [Date last reviewed: 2019-03-07]
Protein Function (UniProtKB)
In the developing eye, has a role in axonal targeting of the R7 photoreceptor where it functions together with tutl. Probably mediates homotypic cell adhesion; the effect is inhibited by Lar.
(UniProt, Q9U4G1)
Summary (Interactive Fly)

Ig superfamily transmembrane protein that coordinates neurite-neurite interactions in the developing optic lobe

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\bdl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9U4G1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
bdl-RA
FBtr0077425
NM_134978
2730
719
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
bdl-PA
FBpp0077115
81.2
719
6.27
Q9U4G1
NP_608822
AAF51028
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with tutl.

(UniProt, Q9U4G1)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bdl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.56

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
eye
(Xu et al., 2004)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval optic stalk
(Cameron et al., 2016)
eye disc | restricted
(Cameron et al., 2016)
lamina | restricted
(Cameron et al., 2016)
embryonic/larval optic stalk surface glial cell
(Cameron et al., 2016)
lamina anlage glial cell
(Cameron et al., 2016)
embryonic/larval wrapping glial cell of the eye disc
(Cameron et al., 2016)
pharate adult stage P8
lamina | restricted
(Cameron et al., 2013)
medulla | restricted
(Cameron et al., 2013)
adult optic lobe | restricted
(Cameron et al., 2013)
adult stage
adult optic lobe | restricted
(Cameron et al., 2013)
lamina | restricted
(Cameron et al., 2013)
medulla | restricted
(Cameron et al., 2013)
medulla layer M6
(Cameron et al., 2013)
medulla layer M3
(Cameron et al., 2013)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Cameron et al., 2013)
Additional Descriptive Data

In third instar larvae, bdl staining visualizes cellular processes from the eye disc through the optic stalk, into the developing lamina. bdl is present in wrapping glia processes, but not in photoreceptor cell axons, in third instar larvae where photoreceptor cell axons begin to project into the optic lobe.

(Cameron et al., 2016)

bdl-protein is detected in part of the pupal and adult medulla, lamina and inner optic lobe. Within the medulla, bdl-protein is found in R7- and R8-axon terminals in medulla layers M3 and M6 as well as in other neuronal processes.

(Cameron et al., 2013)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in plasma membrane
inferred from direct assay
(Cameron et al., 2013)
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.0}bdlMI03534-TG4.0
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult glial cell | subset
(Lee et al., 2018)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\bdl in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of bdl
Transgenic constructs containing regulatory region of bdl
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene partially disrupted in
Df(2L)tutl-bdl
(Cameron et al., 2013)
Gene disrupted in
Df(2L)Exel8011
(Ryder, 2004.4.26)
Df(2L)tutl
(Zhou et al., 2012)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (96)
Hsap\IGSF9
5 of 14
Yes
No
2  
Hsap\IGSF9B
4 of 14
No
No
Hsap\DSCAM
3 of 14
No
No
3  
Hsap\CNTN4
2 of 14
No
No
Hsap\CNTN6
2 of 14
No
No
Hsap\DSCAML1
2 of 14
No
No
2  
Hsap\IGLON5
2 of 14
No
No
Hsap\KIRREL1
2 of 14
No
No
Hsap\KIRREL3
2 of 14
No
No
Hsap\LSAMP
2 of 14
No
No
Hsap\NCAM1
2 of 14
No
No
4  
Hsap\NTM
2 of 14
No
No
Hsap\OPCML
2 of 14
No
No
Hsap\ROBO3
2 of 14
No
No
Hsap\SDK1
2 of 14
No
No
Hsap\SDK2
2 of 14
No
No
1  
Hsap\ADAMTSL3
1 of 14
No
No
Hsap\BSG
1 of 14
No
No
Hsap\CADM1
1 of 14
No
No
Hsap\CADM2
1 of 14
No
No
Hsap\CADM3
1 of 14
No
No
Hsap\CD22
1 of 14
No
No
Hsap\CEACAM1
1 of 14
No
No
Hsap\CEACAM6
1 of 14
No
No
Hsap\CHL1
1 of 14
No
No
Hsap\CNTN1
1 of 14
No
No
Hsap\CNTN2
1 of 14
No
No
Hsap\CNTN3
1 of 14
No
No
Hsap\CNTN5
1 of 14
No
No
Hsap\DCC
1 of 14
No
No
4  
Hsap\FCER1A
1 of 14
No
Yes
Hsap\FCGR1A
1 of 14
No
Yes
Hsap\FCGR1B
1 of 14
No
Yes
Hsap\FCGR2A
1 of 14
No
Yes
Hsap\FCGR2B
1 of 14
No
Yes
Hsap\FCGR2C
1 of 14
No
Yes
Hsap\FCGR3A
1 of 14
No
Yes
Hsap\FCGR3B
1 of 14
No
Yes
Hsap\FCRL3
1 of 14
No
Yes
Hsap\FCRL4
1 of 14
No
Yes
Hsap\FCRL5
1 of 14
No
Yes
Hsap\FCRL6
1 of 14
No
Yes
Hsap\FCRLA
1 of 14
No
Yes
Hsap\FCRLB
1 of 14
No
Yes
Hsap\FGFR1
1 of 14
No
No
Hsap\FGFR2
1 of 14
No
No
Hsap\FGFR4
1 of 14
No
No
2  
Hsap\HMCN1
1 of 14
No
No
Hsap\HMCN2
1 of 14
No
No
Hsap\HSPG2
1 of 14
No
No
Hsap\IGDCC3
1 of 14
No
No
Hsap\IGDCC4
1 of 14
No
No
Hsap\IGSF10
1 of 14
No
No
Hsap\IL1R1
1 of 14
No
No
Hsap\IL1R2
1 of 14
No
Yes
Hsap\IL1RAP
1 of 14
No
No
Hsap\IL1RAPL1
1 of 14
No
No
Hsap\IL1RAPL2
1 of 14
No
No
1  
Hsap\IL1RL1
1 of 14
No
No
Hsap\IL1RL2
1 of 14
No
No
Hsap\IL18R1
1 of 14
No
No
Hsap\IL18RAP
1 of 14
No
No
1  
Hsap\KIRREL2
1 of 14
No
No
Hsap\L1CAM
1 of 14
No
No
11  
Hsap\LAG3
1 of 14
No
Yes
Hsap\LRIG1
1 of 14
No
No
Hsap\LRIT1
1 of 14
No
No
Hsap\LRIT3
1 of 14
No
No
Hsap\MUSK
1 of 14
No
No
1  
Hsap\NCAM2
1 of 14
No
No
Hsap\NECTIN1
1 of 14
No
No
Hsap\NECTIN2
1 of 14
No
No
Hsap\NECTIN3
1 of 14
No
No
Hsap\NECTIN4
1 of 14
No
No
Hsap\NEGR1
1 of 14
No
No
1  
Hsap\NEO1
1 of 14
No
No
Hsap\NFASC
1 of 14
No
No
Hsap\NRCAM
1 of 14
No
No
Hsap\OBSCN
1 of 14
No
No
Hsap\PALLD
1 of 14
No
No
Hsap\PAPLN
1 of 14
No
No
Hsap\PRTG
1 of 14
No
No
Hsap\PTK7
1 of 14
No
No
1  
Hsap\PTPRF
1 of 14
No
No
2  
Hsap\PVR
1 of 14
No
No
1  
Hsap\PXDN
1 of 14
No
No
3  
Hsap\PXDNL
1 of 14
No
No
1  
Hsap\ROBO1
1 of 14
No
No
4  
Hsap\ROBO2
1 of 14
No
No
Hsap\SIGIRR
1 of 14
No
Yes
Hsap\SIGLEC1
1 of 14
No
No
Hsap\TNN
1 of 14
No
No
Hsap\TTN
1 of 14
No
No
Hsap\TYRO3
1 of 14
No
Yes
Hsap\USH2A
1 of 14
No
No
Hsap\VCAM1
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (38)
Rnor\Igsf9
5 of 14
Yes
No
Rnor\Igsf9b
4 of 14
No
No
Rnor\Dscaml1
3 of 14
No
No
Rnor\Dscam
3 of 14
No
No
Rnor\Hmcn1
2 of 14
No
No
Rnor\Iglon5
2 of 14
No
No
Rnor\Bsg
1 of 14
No
No
Rnor\Cadm1
1 of 14
No
No
Rnor\Cadm2
1 of 14
No
No
Rnor\Cadm3
1 of 14
No
No
Rnor\Cd4
1 of 14
No
Yes
Rnor\Cntn1
1 of 14
No
No
Rnor\Cntn4
1 of 14
No
No
Rnor\Dcc
1 of 14
No
No
Rnor\Igdcc3
1 of 14
No
No
Rnor\Igdcc4
1 of 14
No
No
Rnor\Kirrel1
1 of 14
No
No
Rnor\Kirrel2
1 of 14
No
No
Rnor\Kirrel3
1 of 14
No
No
Rnor\Lag3
1 of 14
No
Yes
Rnor\Lrit1
1 of 14
No
No
Rnor\Lsamp
1 of 14
No
No
Rnor\Myot
1 of 14
No
Yes
Rnor\Ncam1
1 of 14
No
No
Rnor\Ncam2
1 of 14
No
No
Rnor\Nectin1
1 of 14
No
No
Rnor\Nectin2
1 of 14
No
No
Rnor\Nectin3
1 of 14
No
No
Rnor\Nectin4
1 of 14
No
No
Rnor\Neo1
1 of 14
No
No
Rnor\Nrcam
1 of 14
No
No
2  
Rnor\Opcml
1 of 14
No
No
Rnor\Prtg
1 of 14
No
Yes
Rnor\Pvr
1 of 14
No
Yes
Rnor\Robo1
1 of 14
No
No
Rnor\Robo2
1 of 14
No
No
Rnor\Sdk2
1 of 14
No
No
Rnor\Siglec5
1 of 14
No
No
Mus musculus (laboratory mouse) (44)
Mmus\Igsf9b
4 of 14
Yes
No
Mmus\Igsf9
4 of 14
Yes
No
Mmus\Dscaml1
3 of 14
No
No
Mmus\Dscam
3 of 14
No
No
1  
Mmus\Iglon5
2 of 14
No
No
Mmus\Prtg
2 of 14
No
Yes
Mmus\Sdk1
2 of 14
No
No
Mmus\Bsg
1 of 14
No
No
1  
Mmus\Cadm1
1 of 14
No
No
Mmus\Cadm2
1 of 14
No
No
Mmus\Cadm3
1 of 14
No
No
Mmus\Cntn1
1 of 14
No
No
Mmus\Cntn5
1 of 14
No
No
Mmus\Cntn6
1 of 14
No
No
Mmus\Dcc
1 of 14
No
No
Mmus\Hmcn1
1 of 14
No
No
Mmus\Hmcn2
1 of 14
No
No
Mmus\Igdcc3
1 of 14
No
No
Mmus\Kirrel2
1 of 14
No
No
1  
Mmus\Kirrel3
1 of 14
No
No
1  
Mmus\Kirrel
1 of 14
No
No
1  
Mmus\Lag3
1 of 14
No
Yes
Mmus\Lrit1
1 of 14
No
No
Mmus\Lrit3
1 of 14
No
No
Mmus\Myot
1 of 14
No
Yes
Mmus\Ncam1
1 of 14
No
No
Mmus\Ncam2
1 of 14
No
No
Mmus\Nectin1
1 of 14
No
No
Mmus\Nectin2
1 of 14
No
No
Mmus\Nectin3
1 of 14
No
No
Mmus\Nectin4
1 of 14
No
No
Mmus\Negr1
1 of 14
No
No
Mmus\Neo1
1 of 14
No
No
Mmus\Nrcam
1 of 14
No
No
Mmus\Ntm
1 of 14
No
No
Mmus\Opcml
1 of 14
No
No
Mmus\Papln
1 of 14
No
No
Mmus\Ptprq
1 of 14
No
No
Mmus\Pvr
1 of 14
No
No
Mmus\Pxdn
1 of 14
No
No
Mmus\Robo1
1 of 14
No
No
Mmus\Robo2
1 of 14
No
No
Mmus\Sdk2
1 of 14
No
No
Mmus\Ttn
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (43)
Xtro\igsf9b
3 of 13
Yes
No
Xtro\col20a1
2 of 13
No
No
Xtro\dscam
2 of 13
No
No
Xtro\igsf9
2 of 13
No
No
Xtro\cadm2
1 of 13
No
No
Xtro\cd22
1 of 13
No
No
Xtro\dcc
1 of 13
No
No
Xtro\dscaml1
1 of 13
No
No
Xtro\fgfr1op2
1 of 13
No
No
Xtro\fgfr3
1 of 13
No
No
Xtro\hmcn1
1 of 13
No
No
Xtro\hmcn2
1 of 13
No
No
Xtro\igdcc3
1 of 13
No
No
Xtro\iglon5
1 of 13
No
No
Xtro\igsf10
1 of 13
No
No
Xtro\il1r1
1 of 13
No
Yes
Xtro\il1rapl2
1 of 13
No
Yes
Xtro\il1rap
1 of 13
No
Yes
Xtro\ldaf1
1 of 13
No
No
Xtro\LOC101735075
1 of 13
No
No
Xtro\LOC108648322
1 of 13
No
No
Xtro\lrig1
1 of 13
No
No
Xtro\mag
1 of 13
No
Yes
Xtro\map3k1
1 of 13
No
Yes
Xtro\mov10
1 of 13
No
No
Xtro\ncam1
1 of 13
No
No
Xtro\nectin1l1
1 of 13
No
Yes
Xtro\nectin1
1 of 13
No
Yes
Xtro\nectin4
1 of 13
No
Yes
Xtro\npffr1.1
1 of 13
No
No
Xtro\nrcam
1 of 13
No
No
Xtro\pecam1
1 of 13
No
Yes
Xtro\prtg
1 of 13
No
No
Xtro\pxdn
1 of 13
No
No
Xtro\rgs2
1 of 13
No
Yes
Xtro\rplp0
1 of 13
No
No
Xtro\spata1
1 of 13
No
Yes
Xtro\tyro3
1 of 13
No
Yes
Xtro\upk2
1 of 13
No
No
Xtro\XB5805949
1 of 13
No
Yes
Xtro\XB5960289
1 of 13
No
No
Xtro\XB5991222
1 of 13
No
No
Xtro\xilr2
1 of 13
No
Yes
Danio rerio (Zebrafish) (63)
Drer\igsf9a
5 of 14
Yes
No
Drer\igsf9ba
4 of 14
No
No
Drer\igsf9bb
4 of 14
No
No
Drer\igsf9b
4 of 14
No
No
Drer\dscama
3 of 14
No
No
Drer\dscamb
3 of 14
No
No
Drer\robo4
3 of 14
No
Yes
Drer\cntn3a.1
2 of 14
No
No
Drer\cntn3a.2
2 of 14
No
No
Drer\robo3
2 of 14
No
No
Drer\aebp1b
1 of 14
No
No
Drer\bsg
1 of 14
No
No
Drer\cadm1a
1 of 14
No
No
Drer\cadm1b
1 of 14
No
No
Drer\cadm2a
1 of 14
No
No
Drer\cadm2b
1 of 14
No
No
Drer\cadm3
1 of 14
No
No
Drer\cadm4
1 of 14
No
No
Drer\cd4-1
1 of 14
No
Yes
Drer\cd22
1 of 14
No
No
Drer\chl1b
1 of 14
No
No
Drer\cntn4
1 of 14
No
No
Drer\dcc
1 of 14
No
No
Drer\hmcn1
1 of 14
No
No
Drer\hmcn2
1 of 14
No
No
Drer\igdcc3
1 of 14
No
No
Drer\itgb4
1 of 14
No
No
Drer\kirrel1b
1 of 14
No
No
Drer\LOC100332721
1 of 14
No
No
Drer\LOC110439987
1 of 14
No
No
Drer\lrit1a
1 of 14
No
No
Drer\lrit3a
1 of 14
No
No
Drer\lrit3b
1 of 14
No
No
Drer\myot
1 of 14
No
Yes
Drer\ncam1a
1 of 14
No
No
Drer\nectin1a
1 of 14
No
No
Drer\nectin1b
1 of 14
No
Yes
Drer\nectin3a
1 of 14
No
No
Drer\nectin3b
1 of 14
No
No
Drer\nectin4a
1 of 14
No
No
Drer\nectin4b
1 of 14
No
Yes
Drer\negr1
1 of 14
No
No
Drer\neo1a
1 of 14
No
No
Drer\neo1b
1 of 14
No
No
Drer\opcml
1 of 14
No
No
Drer\paplna
1 of 14
No
No
Drer\prtga
1 of 14
No
No
Drer\prtgb
1 of 14
No
No
Drer\pvrl2l
1 of 14
No
No
Drer\pxdn
1 of 14
No
No
Drer\robo2
1 of 14
No
No
Drer\sdk1a
1 of 14
No
No
Drer\si:cabz01036022.1
1 of 14
No
Yes
Drer\si:ch73-22o12.1
1 of 14
No
No
Drer\si:ch211-141e20.2
1 of 14
No
No
Drer\si:ch211-214p13.3
1 of 14
No
Yes
Drer\si:ch211-222f23.6
1 of 14
No
No
Drer\si:dkey-23a13.11
1 of 14
No
Yes
Drer\si:dkey-24p1.7
1 of 14
No
No
Drer\si:dkey-27j5.8
1 of 14
No
No
Drer\si:dkey-33i11.1
1 of 14
No
No
Drer\ush2a
1 of 14
No
No
Drer\zgc:77784
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (21)
Cele\igcm-2
4 of 14
Yes
No
Cele\rig-3
2 of 14
No
Yes
Cele\rig-4
2 of 14
No
No
Cele\rig-6
2 of 14
No
No
Cele\zig-8
2 of 14
No
No
Cele\him-4
1 of 14
No
No
Cele\ncam-1
1 of 14
No
No
Cele\rig-5
1 of 14
No
No
Cele\sax-3
1 of 14
No
No
Cele\syg-1
1 of 14
No
No
Cele\syg-2
1 of 14
No
No
Cele\ttn-1
1 of 14
No
No
Cele\unc-40
1 of 14
No
No
Cele\unc-89
1 of 14
No
No
Cele\ver-4
1 of 14
No
No
Cele\zig-1
1 of 14
No
Yes
Cele\zig-2
1 of 14
No
No
Cele\zig-3
1 of 14
No
No
Cele\zig-4
1 of 14
No
No
Cele\zig-7
1 of 14
No
Yes
Cele\zig-11
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (87)
Agam\AgaP_AGAP008943
12 of 12
Yes
Yes
Agam\AgaP_AGAP007928
3 of 12
No
No
Agam\AgaP_AGAP000659
2 of 12
No
No
Agam\AgaP_AGAP000863
2 of 12
No
No
Agam\AgaP_AGAP001126
2 of 12
No
No
Agam\AgaP_AGAP001201
2 of 12
No
No
Agam\AgaP_AGAP001239
2 of 12
No
No
Agam\AgaP_AGAP001242
2 of 12
No
No
Agam\AgaP_AGAP001304
2 of 12
No
No
Agam\AgaP_AGAP002325
2 of 12
No
No
Agam\AgaP_AGAP002494
2 of 12
No
No
Agam\AgaP_AGAP002628
2 of 12
No
No
Agam\AgaP_AGAP002707
2 of 12
No
No
Agam\AgaP_AGAP003235
2 of 12
No
No
Agam\AgaP_AGAP004915
2 of 12
No
No
Agam\AgaP_AGAP005028
2 of 12
No
No
Agam\AgaP_AGAP005068
2 of 12
No
No
Agam\AgaP_AGAP005069
2 of 12
No
No
Agam\AgaP_AGAP005794
2 of 12
No
No
Agam\AgaP_AGAP006274
2 of 12
No
No
Agam\AgaP_AGAP006350
2 of 12
No
No
Agam\AgaP_AGAP007092
2 of 12
No
No
Agam\AgaP_AGAP007500
2 of 12
No
No
Agam\AgaP_AGAP007759
2 of 12
No
No
Agam\AgaP_AGAP008734
2 of 12
No
No
Agam\AgaP_AGAP008778
2 of 12
No
No
Agam\AgaP_AGAP009183
2 of 12
No
No
Agam\AgaP_AGAP009242
2 of 12
No
No
Agam\AgaP_AGAP009245
2 of 12
No
No
Agam\AgaP_AGAP009247
2 of 12
No
No
Agam\AgaP_AGAP009248
2 of 12
No
No
Agam\AgaP_AGAP009250
2 of 12
No
No
Agam\AgaP_AGAP009253
2 of 12
No
No
Agam\AgaP_AGAP009965
2 of 12
No
No
Agam\AgaP_AGAP010221
2 of 12
No
No
Agam\AgaP_AGAP010222
2 of 12
No
No
Agam\AgaP_AGAP010422
2 of 12
No
No
Agam\AgaP_AGAP010542
2 of 12
No
No
Agam\AgaP_AGAP010884
2 of 12
No
No
Agam\AgaP_AGAP011128
2 of 12
No
No
Agam\AgaP_AGAP011194
2 of 12
No
No
Agam\AgaP_AGAP011195
2 of 12
No
No
Agam\AgaP_AGAP012441
2 of 12
No
No
Agam\AgaP_AGAP000217
1 of 12
No
No
Agam\AgaP_AGAP000218
1 of 12
No
No
Agam\AgaP_AGAP001002
1 of 12
No
No
Agam\AgaP_AGAP001048
1 of 12
No
No
Agam\AgaP_AGAP001633
1 of 12
No
No
Agam\AgaP_AGAP001674
1 of 12
No
No
Agam\AgaP_AGAP001824
1 of 12
No
No
Agam\AgaP_AGAP001925
1 of 12
No
No
Agam\AgaP_AGAP002135
1 of 12
No
No
Agam\AgaP_AGAP002336
1 of 12
No
No
Agam\AgaP_AGAP002708
1 of 12
No
No
Agam\AgaP_AGAP002737
1 of 12
No
No
Agam\AgaP_AGAP002802
1 of 12
No
No
Agam\AgaP_AGAP003610
1 of 12
No
No
Agam\AgaP_AGAP004108
1 of 12
No
No
Agam\AgaP_AGAP004902
1 of 12
No
No
Agam\AgaP_AGAP005219
1 of 12
No
No
Agam\AgaP_AGAP006083
1 of 12
No
No
Agam\AgaP_AGAP007091
1 of 12
No
No
Agam\AgaP_AGAP008320
1 of 12
No
No
Agam\AgaP_AGAP008655
1 of 12
No
No
Agam\AgaP_AGAP008776
1 of 12
No
No
Agam\AgaP_AGAP008813
1 of 12
No
No
Agam\AgaP_AGAP009138
1 of 12
No
No
Agam\AgaP_AGAP009518
1 of 12
No
No
Agam\AgaP_AGAP009964
1 of 12
No
No
Agam\AgaP_AGAP010184
1 of 12
No
No
Agam\AgaP_AGAP010185
1 of 12
No
No
Agam\AgaP_AGAP010186
1 of 12
No
No
Agam\AgaP_AGAP010541
1 of 12
No
Yes
Agam\AgaP_AGAP010742
1 of 12
No
No
Agam\AgaP_AGAP010969
1 of 12
No
No
Agam\AgaP_AGAP010970
1 of 12
No
No
Agam\AgaP_AGAP011700
1 of 12
No
No
Agam\AgaP_AGAP012059
1 of 12
No
No
Agam\AgaP_AGAP012385
1 of 12
No
No
Agam\AgaP_AGAP013027
1 of 12
No
No
Agam\AgaP_AGAP013208
1 of 12
No
No
Agam\HPX4
1 of 12
No
No
Agam\IGL1
1 of 12
No
No
Agam\TOLL1A
1 of 12
No
No
Agam\TOLL1B
1 of 12
No
No
Agam\TOLL5A
1 of 12
No
No
Agam\TOLL5B
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:bdl. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (71)
tutl
6 of 13
Dscam1
3 of 13
Dscam2
3 of 13
Dscam4
3 of 13
Fas2
3 of 13
Ama
2 of 13
CG7166
2 of 13
CG34353
2 of 13
Cont
2 of 13
DIP-α
2 of 13
DIP-β
2 of 13
DIP-δ
2 of 13
DIP-ε
2 of 13
DIP-η
2 of 13
DIP-γ
2 of 13
DIP-ι
2 of 13
DIP-κ
2 of 13
DIP-θ
2 of 13
DIP-ζ
2 of 13
dpr1
2 of 13
dpr3
2 of 13
dpr4
2 of 13
dpr5
2 of 13
dpr6
2 of 13
dpr8
2 of 13
dpr9
2 of 13
dpr10
2 of 13
dpr11
2 of 13
dpr12
2 of 13
dpr13
2 of 13
dpr14
2 of 13
dpr15
2 of 13
dpr16
2 of 13
dpr17
2 of 13
dpr18
2 of 13
dpr19
2 of 13
dpr20
2 of 13
Dscam3
2 of 13
klg
2 of 13
Lac
2 of 13
sdk
2 of 13
babos
1 of 13
Bsg
1 of 13
CG13506
1 of 13
CG17839
1 of 13
CG44153
1 of 13
CG45263
1 of 13
DIP-λ
1 of 13
dpr2
1 of 13
dpr7
1 of 13
dpr21
1 of 13
ed
1 of 13
elff
1 of 13
fipi
1 of 13
fred
1 of 13
ImpL2
1 of 13
kirre
1 of 13
Nrg
1 of 13
otk
1 of 13
plum
1 of 13
robo1
1 of 13
robo2
1 of 13
robo3
1 of 13
rst
1 of 13
side
1 of 13
side-VI
1 of 13
sns
1 of 13
Strn-Mlck
1 of 13
Tehao
1 of 13
Tl
1 of 13
wrapper
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    IGSF9; immunoglobulin superfamily member 9
    5 of 14
    609738
         
        IGSF9B; immunoglobulin superfamily member 9B
        4 of 14
        613773
            DSCAM; DS cell adhesion molecule
            3 of 14
            DOWN SYNDROME CELL ADHESION MOLECULE; DSCAM
                 
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                bdl
                suppressible
                Lar
                (Cameron et al., 2013)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Lar
                suppressible
                bdl
                (Cameron et al., 2013)
                tutl
                suppressible
                bdl
                (Cameron et al., 2013)
                External Data
                Subunit Structure (UniProtKB)
                Interacts with tutl.
                (UniProt, Q9U4G1 )
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                External Data
                Linkouts
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2L
                Recombination map
                2-12
                Cytogenetic map
                24E1-24E1
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                24E1-24E1
                Limits computationally determined from genome sequence between P{PZ}tutl01085 and P{EP}Traf1EP578
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                Experimentally Determined Recombination Data
                Location

                2-12

                (FlyBase, 2016)

                2-13.1

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (13)
                Genomic Clones (17)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (33)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 

                polyclonal

                (Cameron et al., 2013)
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments
                    Relationship to Other Genes
                    Source for database merge of
                    Additional comments
                    Nomenclature History
                    Source for database identify of

                    Source for identity of: bdl CG16857

                    (Cameron et al., 2013)
                    Nomenclature comments
                    Etymology
                    Synonyms and Secondary IDs (7)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    Study result (0)
                    Result
                    Result Type
                    Title
                    External Crossreferences and Linkouts ( 45 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    Other crossreferences
                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    FlyMine - An integrated database for Drosophila genomics
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    Linkouts
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    References (56)