FlyBase Gene Report: Dmel\Dscam2

General Information

Symbol

Dmel\Dscam2

Species

D. melanogaster

Name

Down syndrome cell adhesion molecule 2

Annotation Symbol

CG42256

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265296

Gene Model Status

Current

Stock Availability

27 publicly available

Gene Summary

Down syndrome cell adhesion molecule 2 (Dscam2) encodes a transmembrane protein. Its alternative splicing produces two biochemically distinct homophilic binding proteins expressed in different cells. It can mediate both repulsion and adhesion between neurons and contributes to boundary formation, neurite targeting and synapse formation in the brain. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

65E6-65E7

Sequence location

3L:7,159,199..7,189,931 [-]

Recombination map

3-19

RefSeq locus

NT_037436 REGION:7159199..7189931

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables identical protein binding

inferred from physical interaction with FLYBASE:Dscam2; FB:FBgn0265296

(Millard et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables cell-cell adhesion mediator activity

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in homophilic cell-cell adhesion

inferred from direct assay

(Funada et al., 2007, Millard et al., 2007)

involved_in neuron projection morphogenesis

inferred from mutant phenotype

(Millard et al., 2007)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

involved_in central nervous system development

inferred from biological aspect of ancestor with PANTHER:PTN008493410

(GO Reference Genome Project, 2011-)

involved_in dendrite self-avoidance

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

involved_in homophilic cell-cell adhesion

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:Q8TD84

(Gene Ontology Curators, 2002-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in axon

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence model

(Millard et al., 2007)

Gene Group (FlyBase)

DOWN SYNDROME CELL-ADHESION MOLECULES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

DOWN SYNDROME CELL-ADHESION MOLECULES -: The Dscam (Down syndrome cell-adhesion molecule) transmembrane immunoglobulin superfamily proteins regulate axon branching and guidance by mediating both repulsion and adhesion. (Adapted from FBrf0232776, FBrf0145178 and FBrf0193992).

Protein Function (UniProtKB)

Cell adhesion molecule.

(UniProt, Q9VS29)

Summary (Interactive Fly)

immunoglobulin superfamily - Dscam2 homophilic interactions mediate repulsion between neurites of L1 laminar cells in neighbouring columns of the optic lobe

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dscam2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VS29)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.57

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.49

Gene model reviewed during 5.55

Gene model reviewed during 6.02

Gene model reviewed during 5.44

Double stop-codon suppression (UAG, UGA) postulated; FBrf0216884.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dscam2-RE

FBtr0299546

NM_001144425

3476

543

Dscam2-RF

FBtr0299547

NM_001144426

3631

752

Dscam2-RG

FBtr0299548

NM_168195

6195

1808

Dscam2-RH

FBtr0299549

NM_168194

8863

2040

Dscam2-RI

FBtr0299550

NM_001043123

6202

1809

Dscam2-RJ

FBtr0299551

NM_168196

10070

2074

Dscam2-RK

FBtr0299552

NM_001144424

6270

1833

Dscam2-RL

FBtr0302123

NM_001169896

6457

1814

Dscam2-RM

FBtr0302124

NM_001169897

6210

1813

Dscam2-RN

FBtr0330335

NM_001274569

8881

2085

Dscam2-RO

FBtr0330336

NM_001274570

8851

2036

Dscam2-RP

FBtr0330337

NM_001274571

8881

2101

Dscam2-RQ

FBtr0339133

NM_001300035

8681

1968

Dscam2-RR

FBtr0339134

NM_001300036

7573

1967

Dscam2-RS

FBtr0346856

NM_001316478

8881

2046

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dscam2-PE

FBpp0288821

59.1

543

7.22

FBpp0288822

81.9

752

8.00

NP_001137898

ACL83253

Dscam2-PG

FBpp0288823

198.1

1808

7.49

NP_729224

AAF50600

Dscam2-PH

FBpp0288824

223.5

2040

8.16

NP_729223

AAF50602

Dscam2-PI

FBpp0288825

198.5

1809

7.55

NP_001036588

ABI31239

Dscam2-PJ

FBpp0288826

227.6

2074

8.26

FBpp0288827

201.3

1833

7.70

NP_001137896

ACL83251

Dscam2-PL

FBpp0291333

199.0

1814

7.56

FBpp0291334

198.6

1813

7.49

FBpp0303367

228.4

2085

7.81

FBpp0303368

223.1

2036

8.21

FBpp0303369

229.9

2101

7.70

FBpp0308278

216.5

1968

7.87

FBpp0308279

216.2

1967

7.81

FBpp0312398

224.4

2046

8.21

A0A0S0WFE8

NP_001303407

ALI30464

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dscam2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dscam2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.62

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: TI{2A-lexA::p65}Dscam2^{10B-lexA::p65}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

eye disc | restricted

(Li and Sean Millard, 2019)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dscam2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dscam2

View exonic expression by tissue for Dmel\Dscam2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265296

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38788/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265296

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265296

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32387

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dscam2

Transgenic constructs containing regulatory region of Dscam2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6111

(Ryder, 2004.4.26)

Inferred from location ( 1 )

Dp(3;2)GV-CH321-91A23

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die (with Dscam2^10A)

Dscam2^10B

partially lethal - majority die (with Dscam2^10B)

Dscam2^10A

partially lethal - majority die | recessive

viable

Dscam2^unspecified

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dscam2^GD111

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Dscam2^GD111

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Dscam2^GD10877

abnormal neuroanatomy | adult stage

Dscam2^unspecified

abnormal neuroanatomy | adult stage (with Dscam2^10A)

Dscam2^10B

abnormal neuroanatomy | adult stage (with Dscam2^10B)

Dscam2^10A

abnormal neuroanatomy | adult stage | recessive

abnormal neuroanatomy | adult stage | recessive | somatic clone

abnormal neuroanatomy | adult stage | somatic clone

Dscam2^unspecified

abnormal neuroanatomy | recessive | somatic clone

Dscam2^null-3

abnormal neuroanatomy | somatic clone, with Scer\FLP1^dac.325

Dscam2^null-1

abnormal neuroanatomy | somatic clone, with Scer\FLP1^{G5.R27G05.Tag:PEST(mOdc)}

abnormal size | adult stage (with Dscam2^10A)

Dscam2^10B

abnormal size | adult stage (with Dscam2^10B)

Dscam2^10A

abnormal size | adult stage | recessive

abnormal size | adult stage | recessive | somatic clone

Phenotype manifest in

Allele

eye photoreceptor cell

lamina monopolar neuron L1

lamina monopolar neuron L1 (with Dscam2^10A)

Dscam2^10B

lamina monopolar neuron L1 (with Dscam2^10B)

Dscam2^10A

lamina monopolar neuron L1 | somatic clone

lamina monopolar neuron L2

lamina monopolar neuron L2 (with Dscam2^10A)

Dscam2^10B

lamina monopolar neuron L2 (with Dscam2^10B)

Dscam2^10A

lamina monopolar neuron L2 | somatic clone

lamina monopolar neuron L4 | somatic clone, with Scer\FLP1^{G5.R27G05.Tag:PEST(mOdc)}

medulla

mesonotum, with Scer\GAL4^pnr-MD237

Dscam2^GD10877

optic cartridge

Dscam2^null-1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (136)

Hsap\DSCAM

11 of 14

Yes

10 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CEACAM8

1 of 14

Hsap\CEACAM16

1 of 14

Hsap\CEACAM20

1 of 14

Yes

Hsap\CEACAM21

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CSF3R

1 of 14

Yes

Hsap\DCC

1 of 14

Hsap\EMB

1 of 14

Hsap\FCRL2

1 of 14

Yes

Hsap\FCRL3

1 of 14

Yes

Hsap\FCRL4

1 of 14

Yes

Hsap\FCRL5

1 of 14

Yes

Hsap\FCRL6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\IL12RB2

1 of 14

Yes

Hsap\IL18R1

1 of 14

Hsap\IL18RAP

1 of 14

Hsap\IL23R

1 of 14

Yes

Hsap\IL27RA

1 of 14

Yes

Hsap\IL31RA

1 of 14

Yes

Hsap\L1CAM

1 of 14

Hsap\LEPR

1 of 14

Yes

Hsap\LIFR

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PAPLN

1 of 14

Hsap\PECAM1

1 of 14

Yes

Hsap\PIGR

1 of 14

Yes

Hsap\PSG1

1 of 14

Hsap\PSG2

1 of 14

Hsap\PSG3

1 of 14

Yes

Hsap\PSG4

1 of 14

Yes

Hsap\PSG5

1 of 14

Hsap\PSG6

1 of 14

Yes

Hsap\PSG7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SIGLEC5

1 of 14

Hsap\SPEGNB

1 of 14

Hsap\TREML1

1 of 14

Yes

Hsap\TTN

1 of 14

Hsap\USH2A

1 of 14

Hsap\VSIG10

1 of 14

Yes

Hsap\VSIG10L2

1 of 14

Hsap\VSIG10L

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (90)

Rnor\Dscaml1

11 of 14

Yes

Rnor\Dscam

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Csf3r

1 of 14

Yes

Rnor\Emb

1 of 14

Rnor\Fcrl1

1 of 14

Yes

Rnor\Fcrl2

1 of 14

Yes

Rnor\Fcrl5

1 of 14

Yes

Rnor\Gpa33

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Il1r2

1 of 14

Yes

Rnor\Il1rapl1

1 of 14

Yes

Rnor\Il1rapl2

1 of 14

Yes

Rnor\Il1rap

1 of 14

Yes

Rnor\Il1rl1

1 of 14

Yes

Rnor\Il1rl2

1 of 14

Yes

Rnor\Il6st

1 of 14

Yes

Rnor\Il12rb2

1 of 14

Yes

Rnor\Il18r1

1 of 14

Yes

Rnor\Il18rap

1 of 14

Yes

Rnor\Il23r

1 of 14

Yes

Rnor\Il27ra

1 of 14

Yes

Rnor\Il31ra

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Lifr

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Lrfn1

1 of 14

Rnor\Lrfn4

1 of 14

Rnor\Lrfn5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Pecam1

1 of 14

Yes

Rnor\Pigr

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Pxdn

1 of 14

Rnor\RGD1307182

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Vsig2

1 of 14

Yes

Rnor\Vsig10l

1 of 14

Yes

Rnor\Vsig10

1 of 14

Mus musculus (laboratory mouse) (94)

Mmus\Dscam

11 of 14

Yes

10 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Csf3r

1 of 14

Yes

Mmus\Emb

1 of 14

Mmus\Fcrl1

1 of 14

Yes

Mmus\Fcrl5

1 of 14

Yes

Mmus\Fcrls

1 of 14

Yes

Mmus\Gm17783

1 of 14

Yes

Mmus\Gpa33

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Il1r1

1 of 14

Yes

Mmus\Il1r2

1 of 14

Yes

Mmus\Il1rapl1

1 of 14

Yes

Mmus\Il1rapl2

1 of 14

Yes

Mmus\Il1rap

1 of 14

Yes

Mmus\Il1rl1

1 of 14

Yes

Mmus\Il1rl2

1 of 14

Yes

Mmus\Il6st

1 of 14

Yes

Mmus\Il12rb2

1 of 14

Yes

Mmus\Il18r1

1 of 14

Yes

Mmus\Il18rap

1 of 14

Yes

Mmus\Il23r

1 of 14

Yes

Mmus\Il27ra

1 of 14

Yes

Mmus\Il31ra

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Lifr

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Myot

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Papln

1 of 14

Mmus\Pecam1

1 of 14

Yes

Mmus\Pigr

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ttn

1 of 14

Mmus\Vsig2

1 of 14

Yes

Mmus\Vsig10l

1 of 14

Yes

Mmus\Vsig10

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (48)

Xtro\dscam

9 of 13

Yes

Xtro\dscaml1

6 of 13

Xtro\dcc

2 of 13

Xtro\hmcn1

2 of 13

Yes

Xtro\cadm2

1 of 13

Xtro\cd200r1

1 of 13

Yes

Xtro\ceacam8l

1 of 13

Xtro\col20a1

1 of 13

Xtro\crlf1

1 of 13

Yes

Xtro\csf3r

1 of 13

Yes

Xtro\emb

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\il1rapl2

1 of 13

Yes

Xtro\il1rap

1 of 13

Yes

Xtro\il6st

1 of 13

Yes

Xtro\kirrel1

1 of 13

Xtro\lrig1

1 of 13

Xtro\map3k1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\nectin1

1 of 13

Yes

Xtro\nectin3

1 of 13

Yes

Xtro\nectin4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\rplp0

1 of 13

Xtro\sigirr

1 of 13

Yes

Xtro\spata1

1 of 13

Yes

Xtro\tyro3

1 of 13

Yes

Xtro\vsig10

1 of 13

Yes

Xtro\XB5805949

1 of 13

Yes

Xtro\XB5960289

1 of 13

Danio rerio (Zebrafish) (212)

Drer\dscama

11 of 14

Yes

Drer\dscamb

11 of 14

Yes

Drer\dscaml1

9 of 14

Drer\robo4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\prtgb

2 of 14

Drer\robo3

2 of 14

Drer\sdk1a

2 of 14

Drer\si:ch211-57n23.4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\crlf1b

1 of 14

Yes

Drer\csf3r

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\il1rapl1b

1 of 14

Yes

Drer\il1rapl2

1 of 14

Yes

Drer\il1rl1

1 of 14

Yes

Drer\il6st

1 of 14

Yes

Drer\il12rb1

1 of 14

Yes

Drer\il12rb2

1 of 14

Yes

Drer\il12rb2l

1 of 14

Yes

Drer\il23r

1 of 14

Yes

Drer\itgb4

1 of 14

Drer\lepr

1 of 14

Yes

Drer\lifrb

1 of 14

Yes

Drer\LOC569566

1 of 14

Drer\LOC797394

1 of 14

Yes

Drer\LOC799279

1 of 14

Yes

Drer\LOC100002141

1 of 14

Yes

Drer\LOC100003530

1 of 14

Yes

Drer\LOC100004104

1 of 14

Yes

Drer\LOC100006469

1 of 14

Yes

Drer\LOC100006557

1 of 14

Yes

Drer\LOC100006764

1 of 14

Yes

Drer\LOC100006875

1 of 14

Yes

Drer\LOC100007503

1 of 14

Yes

Drer\LOC100007935

1 of 14

Yes

Drer\LOC100007948

1 of 14

Yes

Drer\LOC100148735

1 of 14

Drer\LOC100151078

1 of 14

Yes

Drer\LOC100151468

1 of 14

Yes

Drer\LOC100329818

1 of 14

Yes

Drer\LOC100330694

1 of 14

Yes

Drer\LOC100331045

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100334619

1 of 14

Yes

Drer\LOC100334996

1 of 14

Yes

Drer\LOC100535756

1 of 14

Yes

Drer\LOC100536572

1 of 14

Yes

Drer\LOC100538136

1 of 14

Yes

Drer\LOC101882696

1 of 14

Yes

Drer\LOC101883325

1 of 14

Drer\LOC101883331

1 of 14

Yes

Drer\LOC101883412

1 of 14

Yes

Drer\LOC101883645

1 of 14

Yes

Drer\LOC101884023

1 of 14

Yes

Drer\LOC101884052

1 of 14

Yes

Drer\LOC101886679

1 of 14

Yes

Drer\LOC101886796

1 of 14

Yes

Drer\LOC103908669

1 of 14

Yes

Drer\LOC103909535

1 of 14

Yes

Drer\LOC103909536

1 of 14

Yes

Drer\LOC103909541

1 of 14

Yes

Drer\LOC103909548

1 of 14

Yes

Drer\LOC103909724

1 of 14

Yes

Drer\LOC108181196

1 of 14

Yes

Drer\LOC110437904

1 of 14

Drer\LOC110438256

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ncam1a

1 of 14

Drer\nectin1a

1 of 14

Drer\nectin1b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\pecam1b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch73-27e22.2

1 of 14

Yes

Drer\si:ch73-27e22.4

1 of 14

Yes

Drer\si:ch73-44m9.1

1 of 14

Drer\si:ch73-170d6.3

1 of 14

Yes

Drer\si:ch73-213k20.5

1 of 14

Yes

Drer\si:ch73-256j6.2

1 of 14

Yes

Drer\si:ch73-304f21.1

1 of 14

Yes

Drer\si:ch211-1f22.16

1 of 14

Drer\si:ch211-9d9.7

1 of 14

Drer\si:ch211-105n15.1

1 of 14

Yes

Drer\si:ch211-114l13.12

1 of 14

Yes

Drer\si:ch211-141e20.2

1 of 14

Drer\si:ch211-209l18.2

1 of 14

Yes

Drer\si:ch211-209l18.4

1 of 14

Yes

Drer\si:ch211-213a13.1

1 of 14

Yes

Drer\si:ch211-215e19.3

1 of 14

Drer\si:ch211-215e19.8

1 of 14

Drer\si:ch211-222f23.6

1 of 14

Drer\si:ch211-222k6.3

1 of 14

Yes

Drer\si:ch211-236g6.1

1 of 14

Yes

Drer\si:ch211-239m17.1

1 of 14

Yes

Drer\si:ch211-264f5.2

1 of 14

Yes

Drer\si:ch211-274k16.2

1 of 14

Yes

Drer\si:ch211-274k16.9

1 of 14

Yes

Drer\si:ch1073-214b20.2

1 of 14

Yes

Drer\si:dkey-19a16.2

1 of 14

Yes

Drer\si:dkey-19a16.4

1 of 14

Yes

Drer\si:dkey-19a16.5

1 of 14

Yes

Drer\si:dkey-19a16.7

1 of 14

Yes

Drer\si:dkey-19a16.12

1 of 14

Yes

Drer\si:dkey-24p1.1

1 of 14

Drer\si:dkey-27j5.8

1 of 14

Drer\si:dkey-31e10.1

1 of 14

Yes

Drer\si:dkey-31e10.5

1 of 14

Yes

Drer\si:dkey-33i11.1

1 of 14

Drer\si:dkey-102c8.2

1 of 14

Yes

Drer\si:dkey-102c8.3

1 of 14

Yes

Drer\si:dkey-182g1.2

1 of 14

Yes

Drer\si:dkey-182g1.3

1 of 14

Yes

Drer\si:dkey-182g1.10

1 of 14

Yes

Drer\si:dkey-222f2.7

1 of 14

Yes

Drer\si:dkey-253d23.3

1 of 14

Yes

Drer\si:dkey-253d23.4

1 of 14

Yes

Drer\si:dkeyp-97a10.3

1 of 14

Yes

Drer\si:dkeyp-104b3.1

1 of 14

Drer\si:rp71-1i20.1

1 of 14

Yes

Drer\si:rp71-1i20.2

1 of 14

Yes

Drer\si:rp71-36a1.1

1 of 14

Yes

Drer\si:rp71-36a1.2

1 of 14

Yes

Drer\si:rp71-36a1.3

1 of 14

Yes

Drer\si:rp71-36a1.5

1 of 14

Yes

Drer\sigirr

1 of 14

Yes

Drer\ush2a

1 of 14

Drer\vsig10

1 of 14

Drer\vsig10l

1 of 14

Yes

Drer\zgc:77784

1 of 14

Drer\zgc:113337

1 of 14

Yes

Drer\zgc:171490

1 of 14

Yes

Drer\zgc:171497

1 of 14

Yes

Drer\zgc:171500

1 of 14

Yes

Drer\zgc:171601

1 of 14

Yes

Drer\zgc:171686

1 of 14

Yes

Drer\zgc:171887

1 of 14

Yes

Drer\zgc:172133

1 of 14

Yes

Drer\zmp:0000000936

1 of 14

Yes

Drer\zmp:0000001161

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\igcm-2

2 of 14

Yes

Cele\rig-3

2 of 14

Yes

Cele\rig-4

2 of 14

Yes

Cele\zig-2

2 of 14

Yes

Cele\zig-3

2 of 14

Yes

Cele\zig-4

2 of 14

Yes

Cele\zig-8

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (92)

Agam\AgaP_AGAP004902

11 of 12

Yes

5 of 12

4 of 12

4 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dscam2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (84)

Dscam1

9 of 13

Dscam4

9 of 13

Dscam3

6 of 13

bdl

3 of 13

sdk

3 of 13

tutl

3 of 13

Bsg

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Lac

2 of 13

Lar

2 of 13

rst

2 of 13

Ama

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

fra

1 of 13

fred

1 of 13

hbs

1 of 13

klg

1 of 13

MstProx

1 of 13

nkt

1 of 13

Nrg

1 of 13

nrm

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Pxn

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sls

1 of 13

sns

1 of 13

Tehao

1 of 13

tei

1 of 13

Tollo

1 of 13

trol

1 of 13

wrapper

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DSCAM; DS cell adhesion molecule

11 of 14

DOWN SYNDROME CELL ADHESION MOLECULE; DSCAM

DSCAML1; DS cell adhesion molecule like 1

10 of 14

611782

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dscam2

anti tag coimmunoprecipitation, anti tag western blot, enzyme linked immunosorbent assay

(Ozkan et al., 2013, Millard et al., 2007)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265296

MIST (protein-protein) - An integrated Molecular Interaction Database

38788

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

DSCAM interactions

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

(Millard et al., 2007)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-19

Cytogenetic map

65E6-65E7

Sequence location

3L:7,159,199..7,189,931 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

65E6-65E7

Limits computationally determined from genome sequence between P{PZ}corn⁰⁴²⁰² and P{lacW}Cdc27^L7123

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-19

(FlyBase, 2016)

3-16.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (27)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

40552

w¹¹¹⁸; P{GMR89E06-GAL4}attP2

40553

w¹¹¹⁸; P{GMR89E07-GAL4}attP2

46888

w¹¹¹⁸; P{GMR89E11-GAL4}attP2

54347

w¹¹¹⁸; P{GMR89E03-lexA}attP40

54997

w¹¹¹⁸; P{GMR89F04-lexA}attP40

54998

w¹¹¹⁸; P{GMR89F07-lexA}attP40

61625

w¹¹¹⁸; P{GMR89E07-lexA}attP40

69898

w¹¹¹⁸; P{R89E07-p65.AD}attP40

68692

w¹¹¹⁸; P{R89E06-GAL4.DBD}attP2

32389R-2

v107939

v1100

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (32)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0265296

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Millard et al., 2007)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Annotation CG17742 eliminated in release 5.36 of the genome annotation; corresponds to region within 3' UTR of annotation CG42256.

(FlyBase Genome Annotators, 2011)

Dscam2 is required to restrict the connections formed by individual L1 lamina neurons to single columns in the visual system.

(Millard et al., 2007)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG32387 CG32389

(FlyBase Genome Annotators, 2008)

Source for merge of: CG32387 BcDNA:AT03867

(FlyBase, 1996-)

Source for merge of: Dscam2 CG42256

(Zipursky, 2011.4.20)

Source for merge of: Dscam2 CG17742

(FlyBase Genome Annotators, 2012)

Additional comments

Annotation CG42256 and previously withdrawn annotation CG17742 merged in release 5.49 of the genome annotation. Merge based on RNA-Seq junction and expression data.

(FlyBase Genome Annotators, 2012)

Annotations CG32387 and CG32389 merged as CG42256 in release 5.8 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Source for merge of CG32387 BcDNA:AT03867 was shared cDNA (AT03867) ( date:030529 ).

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

BcDNA:AT03867

CG14828

CG17742

(Rodriguez et al., 2012, FlyBase Genome Annotators, 2011, Keleman et al., 2009.8.5)

CG32387

(Funada et al., 2007)

CG32389

(Japanese National Institute of Genetics, 2012.5.21, Yano et al., 2012)

CG42256

(Hosono et al., 2015, Ashwal-Fluss et al., 2014, Jungreis et al., 2011, Zipursky, 2011.4.20, Ni et al., 2010.12.1, Wasbrough et al., 2010, FlyBase Genome Annotators, 2008)

CG8618

CG8619

CT14580

(Hynes and Zhao, 2000)

CT14584

(Hynes and Zhao, 2000)

CT34644

(Hynes and Zhao, 2000)

DSCAM

(Moyer et al., 2021)

DmDscam2

(Li et al., 2025)

Dscam-like

(Hynes and Zhao, 2000)

dscam2

(Fischer et al., 2024)

Name Synonyms

CG32387

CG32389

Down syndrome cell adhesion molecule 2

Secondary FlyBase IDs

FBgn0263218
FBgn0250790
FBgn0259141
FBgn0052387
FBgn0035747
FBgn0035748
FBgn0035749
FBgn0063359
FBgn0052389
FBgn0035746

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 91 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38788

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VS29

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VS29

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VS29

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265296

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38788/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265296

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265296

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42256

MARRVEL_MODEL - MARRVEL (model organism gene)

38788

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0265296

DroID - A comprehensive database of gene and protein interactions.

FBgn0265296

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dscam2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0265296

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32387

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0265296

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

38788

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

DSCAM interactions

References (93)

The following external sites may use different assemblies or annotations than FlyBase.

-0.62

Report Sections