Gene model reviewed during 5.39
FBrf0064540 suggests that there are 2 forms of nrm, a membrane and secreted form. It is unclear which of the curated nrm transcripts corresponds to which isoform.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
4.6 (northern blot)
None of the polypeptides share 100% sequence identity.
1011 (aa); 113 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nrm using the Feature Mapper tool.
In the PNS, nrm expression begins at stage 9 at which time two large SMCs can be identified in most segments. During germ band extension and retraction, the number of nrm-expressing cells increases dramatically. Most of these cells will become part of the PNS. During germ band retraction, nrm expression is much reduced and by the end of stage 12, expression is barely detectable. At later embryonic stages, nrm is expressed in developing muscles. In stage 15, many muscle precursors are weakly visible. During stage 16, labeling becomes much more intense. Most muscles are labeled, and some, e.g. 6,7,12, and 13 are consistently labeled darker than most others.
GBrowse - Visual display of RNA-Seq signalsView Dmel\nrm in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: nrm CG8779
Source for merge of: nrm CG41452 CG32458
Annotations CG8779, CG41452 and CG32458 merged as CG43079 in release 5.31 of the genome annotation.
New annotation (CG41452) in release 5.1 of the genome annotation.
New annotation (CG32458) in release 3 of the genome annotation.
nrm expression during embryogenesis has been analysed in wild-type and mutant flies.
nrm is expressed in sensory mother cells and developing muscles. Immunoblots of Schneider 2 cells transfected with nrm indicate the protein is present in a membrane-associated form and a secreted form. Cell aggregation assays suggest nrm is a homophilic cell adhesion molecule that is secreted or released after proteolysis. Genetic analysis indicates nrm is an essential gene required for larval viability. It is proposed that nrm may play a role as a cell adhesion molecule in clustering cells of the PNS, neuronal fasciculation and/or pathfinding.