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FB2026_01
,
released March 12, 2026
43-49, nephrin
single pass transmembrane protein expressed on the surface of fusion competent myoblasts - essential for fusion of embryonic myoblasts - contributes to formation and function of the nephrocyte diaphragm and cell sorting within the developing ommatidia
Please see the JBrowse view of Dmel\sns for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
8.035 (compiled cDNA)
None of the polypeptides share 100% sequence identity.
1483 (aa); 162 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sns using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Expression of sns is observed in two bands in the fusion-competent myoblasts of the somatic and visceral mesoderm, a dorsal band corresponding to the fusion-competent myoblasts of the visceral mesoderm and a ventral band corresponding to the fusion-competent myoblasts of the somatic mesoderm.
sns transcript is detected in the embryonic visceral and somatic musculature.
sns protein is expressed only in terminally differentiated myoblasts.
sns protein is enriched at the cell membrane. The protein localizes to discrete sites in the membrane as muscle founder cell fusion progresses, and amounts of the protein decline during the process.
sns protein is localized to regions of cell-cell contact in mononucleate embryonic garland cells and binucleate embryonic/larval garland cells; distribution is also observed in in intracellular and cell surface puncta. kirre protein is partially colocalized with sns protein. sns protein is expressed in garland cells at all larval stages; immuno-EM reveals sns protein to be localized to the nephrocyte diaphragm of larval garland cells in second and third instar larvae.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sns in JBrowse2-59
2-57.9
2-58.2--61.5
Maps between positions 43 and 49 on chromosome 2.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
snsis required for the formation of syncytia within the visceral musculature of the midgut.
sns is essential for myoblast fusion.
sns mutant embryos show a dramatic absence of muscle fibres and a large number of unfused myosin-expressing cells. Formation of the heart and visceral musculature appears normal, the CNS and PNS show no gross abnormalities, and no defects in dorsal closure are seen.
Source for merge of: sns 43-49
Source for merge of: sns CG18464 CG12495 CG13754 CG13753 CG13752 CG2385 CG8278
Source for merge of: sns CG13755
Source for merge of sns CG18464 CG12495 CG13754 CG13753 CG13752 CG2385 CG8278 was sequence comparison ( date:000622 ).
Source for merge of sns CG13755 was sequence comparison ( date:001104 ).
