FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
dock, sns
FlyBase ID
FBig0000098154
Interaction Network
Interactions Browser links
dock network
sns network
Reported Interactions
FBrf0221091-10.coIP.WB
Reference
Kaipa et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
sns 

Sns

bait

HA tag

sns 
dock 

Dock

prey

FLAG tag

dock 
dock 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
sns 
phosphotyrosine residues
necessary binding region
dock 
SH3 domains
sufficient binding region
aa 1-279
dock 
SH2 domain
sufficient binding region
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Kaipa et al., 2013)

Full length sns can bind either the SH2 or SH3 domains of dock.

(Kaipa et al., 2013)
FBrf0221091-11.coIP.WB
Reference
Kaipa et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
dock 

Dock

bait

FLAG tag

dock 
sns 

Sns

prey

HA tag

sns 
sns 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
sns 
intracellular domain
sufficient binding region
sns 
phosphotyrosine residues
necessary binding region
dock 
SH3 domains
sufficient binding region
aa 1-279
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Kaipa et al., 2013)

In this assay, the dock SH3 domains could bind the intracellular domain of sns, but the dock SH2 domain could bind only full length sns.

(Kaipa et al., 2013)
FBrf0221091-12.FC.FM
Reference
Kaipa et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
dock 

Dock

neutral component

N-terminal YFP tag

dock 

Dock

neutral component

N-terminal YFP tag

dock 
dock 

Dock

neutral component

N-terminal YFP tag

dock 
sns 

Sns

neutral component

C-terminal YFP tag

sns 
sns 

Sns

neutral component

C-terminal YFP tag

sns 

Sns

neutral component

C-terminal YFP tag

sns 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
sns 
intracellular domain
sufficient binding region
dock 
SH3 domains
necessary binding region
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cells S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Kaipa et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)