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Citation
Lee, D.M., Chen, E.H. (2019). Drosophila Myoblast Fusion: Invasion and Resistance for the Ultimate Union.  A. Rev. Genet. 53(): 67--91.
FlyBase ID
FBrf0244178
Publication Type
Review
Abstract

Cell-cell fusion is indispensable for creating life and building syncytial tissues and organs. Ever since the discovery of cell-cell fusion, how cells join together to form zygotes and multinucleated syncytia has remained a fundamental question in cell and developmental biology. In the past two decades, Drosophila myoblast fusion has been used as a powerful genetic model to unravel mechanisms underlying cell-cell fusion in vivo. Many evolutionarily conserved fusion-promoting factors have been identified and so has a surprising and conserved cellular mechanism. In this review, we revisit key findings in Drosophila myoblast fusion and highlight the critical roles of cellular invasion and resistance in driving cell membrane fusion.

PubMed ID
PubMed Central ID
PMC7448821 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    A. Rev. Genet.
    Title
    Annual Review of Genetics
    Publication Year
    1967-
    ISBN/ISSN
    0066-4197
    Data From Reference