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FB2026_01
,
released March 12, 2026
Dcrk
Please see the JBrowse view of Dmel\Crk for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.47
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.39
Gene model reviewed during 5.55
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
1.3 (northern blot)
271 (aa); 37 (kD observed); 31 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Crk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Crk transcripts are abundant throughout embryogenesis, decline in larvae, reappear during pupal stages and are detected in adults on northern blots. Transcripts are first detected by in situ hybridization in stage 4 embryos just prior to cellularization where they are concentrated around the periphery of the embryo. As cellularization occurs, transcripts are still present at the edge of the newly forming cells but not at the termini of the embryo. During gastrulation Crk transcripts are observed in the invaginating mesoderm as well as in some lateral cells that will contribute to ectodermally derived tissue. In stage 8, expression is apparent in the anterior and posterior midgut primordia and in the cells surrounding the cephalic furrow. This expression remains strong through stages 9-12. In late stage 13, Crk transcript expression is strongest in the visceral mesoderm of the anterior and posterior midgut and in the ventral nerve cord. It is also present in the somatic mesoderm but not in the amnioserosa. By stage 16, transcript levels have declined in some tissues but are still strong in visceral musculature, ventral nerve cord, and the cephalic region. Low levels of Crk transcript are detected in mature muscle fibers.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Crk in JBrowse4-0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Isolated in an embryonic expression library screened with the consensus SRK-binding site found in mbc.
Source for identity of: Crk CG1587
