FB2026_02 , released June 18, 2026
Allele: Dmel\CrkΔattP
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General Information
Symbol
Dmel\CrkΔattP
Species
D. melanogaster
Name
FlyBase ID
FBal0352434
Feature type
allele
Associated gene
Dmel\Crk
Associated Insertion(s)
TI{TI}CrkΔattP
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Spracklen et al., 2019)
Mutagen
CRISPR/Cas9
(Spracklen et al., 2019)
Progenitor genotype
Associated Insertion(s)
TI{TI}CrkΔattP
Cytology
Description

The Crk coding sequence has been replaced with an attP recombination site and a loxP-flanked, positive visual marker (3xP3-DsRed expressed in the eye).

(Spracklen et al., 2019)
Allele components
Component
Use(s)
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Maternal-zygotic and maternal-only Crk-mutant embryos (i.e. all progeny from CrkΔattP heterozygous males crossed to CrkΔattP homozygous females rescued to adulthood by CrkFRT.gen, but in which the Crk genomic segment has been FLP-excised) frequently exhibit morphological defects, which can be denticle belt deletion or fusion, ventral or dorsal holes, severe pattern disruption and/or cuticle fragments.

      Maternal Crk-mutant embryos from CrkΔattP homozygous females rescued to adulthood by CrkFRT.gen, but in which the Crk genomic segment has been FLP-excised, frequently exhibit defects in cellularization, leading to variable size yolk channels.

      (Spracklen et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CrkΔattP
      crkΔattP
      (Spracklen et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)