FlyBase Gene Report: Hsap\PTPN11

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Gene: Hsap\PTPN11

General Information

Symbol

Hsap\PTPN11

Species

H. sapiens

Name

protein tyrosine phosphatase, non-receptor type 11

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0017597

Gene Model Status

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

PTPN11, SHP-2

Key Links

Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == PTPN11; HGNC:9644.

(FlyBase Curators, 1992-)

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hsap\PTPN11

Transgenic constructs containing regulatory region of Hsap\PTPN11

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of P-stage | heat sensitive, with Scer\GAL4^byn.PU

Hsap\PTPN11^Y279C.UAS

partially lethal, with Scer\GAL4^byn.PU

partially lethal, with Scer\GAL4^ptc.PU

partially lethal - majority die, with Scer\GAL4^C-765

Hsap\PTPN11^D61G.UAS

partially lethal - majority die | heat sensitive, with Scer\GAL4^C-765

Hsap\PTPN11^Y279C.UAS

partially lethal - majority live, with Scer\GAL4^C-765

Phenotype manifest in

Allele

crossvein | decreased number | ectopic, with Scer\GAL4^C-765

wing vein | cell non-autonomous, with Scer\GAL4^ptc.PU

wing vein | cell non-autonomous | heat sensitive, with Scer\GAL4^ptc.PU

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (40)

12 of 14

Yes

Yes

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

1 of 14

No

No

0

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 6 )

Allele

Disease

Evidence

References

Hsap\PTPN11^D61G.UAS

model of juvenile myelomonocytic leukemia

CEA

(Das et al., 2021)

model of Noonan syndrome

CEA

(Das et al., 2021)

Hsap\PTPN11^Y279C.UAS

model of Noonan syndrome with multiple lentigines

CEA

(Das et al., 2021)

Hsap\PTPN11^N308D.UAS

model of Noonan syndrome

CEA

(Das et al., 2021)

model of Noonan syndrome 1

CEA

(Baumann et al., 2024, Leahy et al., 2024)

model of Noonan syndrome with multiple lentigines 1

CEA

(Baumann et al., 2024)

Hsap\PTPN11^R498W.UAS

model of Noonan syndrome with multiple lentigines

CEA

(Das et al., 2021)

Hsap\PTPN11^Q510E.UAS

model of Noonan syndrome with multiple lentigines

CEA

(Das et al., 2021)

Hsap\PTPN11^Q510P.UAS

model of Noonan syndrome with multiple lentigines

CEA

(Das et al., 2021)

DOES NOT model Noonan syndrome 1

CEA

(Baumann et al., 2024)

DOES NOT model Noonan syndrome with multiple lentigines 1

CEA

(Baumann et al., 2024)

model of Noonan syndrome with multiple lentigines 1

CEA

(Leahy et al., 2024)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Hsap\PTPN11^Q510P.UAS

model of Noonan syndrome with multiple lentigines 1

is ameliorated by Syn⁹⁷

(Leahy et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

(Perkins et al., 1996)

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

Stocks and Reagents

Stocks (0)

Other Comments

Hsap\PTPN11 expression in Drosophila rescues the lethality associated with csw mutations, Hsap\PTPN11 is the functional vertebrate homolog of csw.

(Perkins et al., 1996)

Relationship to Other Genes

Source for database merge of

Additional comments

FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

(FlyBase Curators, 1992-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

BPTP3

(HGNC Curators and FlyBase Curators, 2013-)

Hsap\PTPN11

(Leahy et al., 2024, Rodríguez-Martín et al., 2024)

NS1

(HGNC Curators and FlyBase Curators, 2013-)

PTP2C

(HGNC Curators and FlyBase Curators, 2013-)

PTPN11

(Leahy et al., 2023, HGNC Curators and FlyBase Curators, 2013-)

SH-PTP2

(HGNC Curators and FlyBase Curators, 2013-)

SHP-2

(HGNC Curators and FlyBase Curators, 2013-, Perkins et al., 1996)

SHP2

(HGNC Curators and FlyBase Curators, 2013-)

hPTPN11

(Das et al., 2021)

hSHP-2

(Ecovoiu et al., 2022)

Name Synonyms

Noonan syndrome 1

(HGNC Curators and FlyBase Curators, 2013-)

Protein-tyrosine phosphatase nonreceptor-type 11

SH2 domain-containing protein tyrosine phosphatase 2

(HGNC Curators and FlyBase Curators, 2013-)

protein tyrosine phosphatase non-receptor type 11

(HGNC Curators and FlyBase Curators, 2013-)

protein tyrosine phosphatase, non-receptor type 11

(HGNC Curators and FlyBase Curators, 2013-)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 9 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

5781

Other crossreferences

Ensembl_Homo_sapiens -

ENSG00000179295

HUGO Gene Nomenclature Committee -

PTPN11; protein tyrosine phosphatase non-receptor type 11

MARRVEL - MARRVEL (human gene)

PTPN11

OMIM_GENE - Online Mendelian Inheritance in Man (Genes)

PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 11; PTPN11

OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)

References (10)