Socs, Suppressor of cytokine signaling 36E
inhibitor of JAK/STAT pathway, works vie a protein degradation pathway, cooperates with EGFR to regulate oncogenic transformation, optimizes motile cell specification in the ovary, regulator of niche competition in the testis, regulated by Histone demethylase
Gene model reviewed during 5.51
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.44
Stop-codon suppression (UAG) postulated; FBrf0216884.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Socs36E using the Feature Mapper tool.
Comment: expressed where the proventriculus joins the anterior midgut
Expression of Socs36E in wild-type embryos is higher on the inside of the hindgut curve.
Socs36E transcript is expressed in a striped pattern similar to that of os through germ band extension. During oogenesis, Socs36E transcript is expressed in the polar follicle cells, and in the follicle cells near the polar follicle cells.
The 2.5 kb Socs36E transcript is observed in S2 cultured cells but not in vivo. Strong transcript expression is observed from embryonic stage 5 through stage 15 (2-13 hrs AEL). Weak expression is observed from late stage 15 through stage 17, and faint expression is observed in third instar larvae and in pupae. Early embryonic expression is observed in dorsal/ventral stripes. By stage 9, these stripes are mesodermal and segmentally repeated.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Socs36E in GBrowse 2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Somatic Socs36E non-autonomously regulates the self-renewal of germline stem cells in the testis.
Socs36E suppresses JAK/STAT signalling in somatic cyst progenitor cells in the testis, preventing them from out-competing the germline stem cells.
dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway.
Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against Socs36E results in a 3-fold increase in JAK/STAT activity.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.